TY - JOUR
T1 - Variances in BCG protection against COVID-19 mortality
T2 - A global assessment
AU - Sarfraz, Zouina
AU - Sarfraz, Azza
AU - Pandav, Krunal
AU - Singh Makkar, Sarabjot
AU - Hasan Siddiqui, Saman
AU - Patel, Gaurav
AU - Platero-Portillo, Tania
AU - Singh, Bishnu Mohan
AU - Maideen, Mohamed Iburahim Haja
AU - Sarvepalli, Deepika
AU - Sarfraz, Muzna
AU - Cardona-Guzman, Jose
AU - Sanchez-Gonzalez, Marcos A.
AU - Cherrez-Ojeda, Ivan
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/8
Y1 - 2021/8
N2 - The BCG vaccine is known to impart nonspecific immunological benefits alongside conferring protection to tuberculosis in endemic regions. It is also known to protect against bladder cancer and other respiratory tract infections. During the coronavirus disease 2019 (COVID-19) pandemic, the BCG vaccine has gained attention due to its role in conferring protective immunity. We demonstrate the potential immunological protective mechanisms that play a role against COVID-19. We conduct a global assessment of the countries that have the highest and lowest mortality rates determined by an a priori methodology. Lastly, we discuss the potential limitations of incorporating BCG vaccines as potential strategies against COVID-19 and provide recommendations regarding their use in ongoing and future epidemics.
AB - The BCG vaccine is known to impart nonspecific immunological benefits alongside conferring protection to tuberculosis in endemic regions. It is also known to protect against bladder cancer and other respiratory tract infections. During the coronavirus disease 2019 (COVID-19) pandemic, the BCG vaccine has gained attention due to its role in conferring protective immunity. We demonstrate the potential immunological protective mechanisms that play a role against COVID-19. We conduct a global assessment of the countries that have the highest and lowest mortality rates determined by an a priori methodology. Lastly, we discuss the potential limitations of incorporating BCG vaccines as potential strategies against COVID-19 and provide recommendations regarding their use in ongoing and future epidemics.
KW - BCG vaccine
KW - Coronavirus
KW - Heterologous immunity
KW - Innate immunity
KW - Policy
UR - https://www.scopus.com/pages/publications/85107652357
U2 - 10.1016/j.jctube.2021.100249
DO - 10.1016/j.jctube.2021.100249
M3 - Artículo
AN - SCOPUS:85107652357
SN - 2405-5794
VL - 24
JO - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
JF - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
M1 - 100249
ER -
