TY - JOUR
T1 - Therapeutic promises of ginkgolide A
T2 - A literature-based review
AU - Sarkar, Chandan
AU - Quispe, Cristina
AU - Jamaddar, Sarmin
AU - Hossain, Rajib
AU - Ray, Pranta
AU - Mondal, Milon
AU - Abdulwanis Mohamed, Zeinab
AU - Sani Jaafaru, Mohammed
AU - Salehi, Bahare
AU - Islam, Muhammad Torequl
AU - Faizal Abdull Razis, Ahmad
AU - Martorell, Miquel
AU - Pastene-Navarrete, Edgar
AU - Sharifi-Rad, Javad
N1 - Publisher Copyright:
© 2020 The Authors
PY - 2020/12
Y1 - 2020/12
N2 - Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of scientific reports in the databases. A total 30 articles included in this review suggests that ginkgolide A has many important biological activities, including anti-inflammatory, anticancer, anxiolytic-like, anti-atherosclerosis and anti-atherombosis, neuro- and hepatoprotective effects. There is a lack of its toxicological (e.g. toxicity, cytotoxicity, genotoxicity and mutagenitcity) profile. In conclusion, ginkgolide A may be one of the potential therapeutic lead compounds, especially for the treatment of cardiovascular, hepatological, and neurological diseases and disorders. More studies are necessary on this hopeful therapeutic agent.
AB - Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of scientific reports in the databases. A total 30 articles included in this review suggests that ginkgolide A has many important biological activities, including anti-inflammatory, anticancer, anxiolytic-like, anti-atherosclerosis and anti-atherombosis, neuro- and hepatoprotective effects. There is a lack of its toxicological (e.g. toxicity, cytotoxicity, genotoxicity and mutagenitcity) profile. In conclusion, ginkgolide A may be one of the potential therapeutic lead compounds, especially for the treatment of cardiovascular, hepatological, and neurological diseases and disorders. More studies are necessary on this hopeful therapeutic agent.
KW - Cancer
KW - Ginkgolide A
KW - Inflammation
KW - Neurological activity
KW - Thrombosis
UR - https://www.scopus.com/pages/publications/85095420403
U2 - 10.1016/j.biopha.2020.110908
DO - 10.1016/j.biopha.2020.110908
M3 - Artículo de revisión
C2 - 33254431
AN - SCOPUS:85095420403
SN - 0753-3322
VL - 132
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
M1 - 110908
ER -
