TY - JOUR
T1 - Therapeutic potential of rosmarinic acid
T2 - A comprehensive review
AU - Nadeem, Muhammad
AU - Imran, Muhammad
AU - Gondal, Tanweer Aslam
AU - Imran, Ali
AU - Shahbaz, Muhammad
AU - Amir, Rai Muhammad
AU - Sajid, Muhammad Wasim
AU - Qaisrani, Tahira Batool
AU - Atif, Muhammad
AU - Hussain, Ghulam
AU - Salehi, Bahare
AU - Ostrander, Elise Adrian
AU - Martorell, Miquel
AU - Sharifi-Rad, Javad
AU - Cho, William C.
AU - Martins, Natália
N1 - Publisher Copyright:
© 2019 by the authors.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Naturally occurring food-derived active ingredients have received huge attention for their chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) is a caffeic acid ester and a naturally-occurring phenolic compound in a number of plants belonging to the Lamiaceae family, such as Rosmarinus officinalis (rosemary) from which it was formerly isolated. RA intervenes in carcinogenesis through different ways, including in tumor cell proliferation, apoptosis, metastasis, and inflammation. On the other hand, it also exerts powerful antimicrobial, anti-inflammatory, antioxidant and even antidepressant, anti-aging effects. The present review aims to provide an overview on anticancer activities of RA and to deliberate its therapeutic potential against a wide variety of diseases. Given the current evidence, RA may be considered as part of the daily diet in the treatment of several diseases, with pre-determined doses avoiding cytotoxicity.
AB - Naturally occurring food-derived active ingredients have received huge attention for their chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) is a caffeic acid ester and a naturally-occurring phenolic compound in a number of plants belonging to the Lamiaceae family, such as Rosmarinus officinalis (rosemary) from which it was formerly isolated. RA intervenes in carcinogenesis through different ways, including in tumor cell proliferation, apoptosis, metastasis, and inflammation. On the other hand, it also exerts powerful antimicrobial, anti-inflammatory, antioxidant and even antidepressant, anti-aging effects. The present review aims to provide an overview on anticancer activities of RA and to deliberate its therapeutic potential against a wide variety of diseases. Given the current evidence, RA may be considered as part of the daily diet in the treatment of several diseases, with pre-determined doses avoiding cytotoxicity.
KW - Anticancer
KW - Antidiabetic
KW - Antioxidant
KW - Cardioprotective
KW - Oxidative stress
KW - Rosemary
KW - Rosmarinic acid
UR - https://www.scopus.com/pages/publications/85070670680
U2 - 10.3390/app9153139
DO - 10.3390/app9153139
M3 - Artículo de revisión
AN - SCOPUS:85070670680
SN - 2076-3417
VL - 9
JO - Applied Sciences (Switzerland)
JF - Applied Sciences (Switzerland)
IS - 15
M1 - 3139
ER -