TY - JOUR
T1 - Therapeutic Potential of Isoflavones with an Emphasis on Daidzein
AU - Alshehri, Mohammed M.
AU - Sharifi-Rad, Javad
AU - Herrera-Bravo, Jesús
AU - Jara, Evelyn L.
AU - Salazar, Luis A.
AU - Kregiel, Dorota
AU - Uprety, Yadav
AU - Akram, Muhammad
AU - Iqbal, Mehwish
AU - Martorell, Miquel
AU - Torrens-Mas, Margalida
AU - Pons, Daniel Gabriel
AU - Daştan, Sevgi Durna
AU - Cruz-Martins, Natália
AU - Ozdemir, Fethi Ahmet
AU - Kumar, Manoj
AU - Cho, William C.
N1 - Publisher Copyright:
© 2021 Mohammed M. Alshehri et al.
PY - 2021
Y1 - 2021
N2 - Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties.
AB - Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties.
UR - https://www.scopus.com/pages/publications/85115813446
U2 - 10.1155/2021/6331630
DO - 10.1155/2021/6331630
M3 - Artículo de revisión
C2 - 34539970
AN - SCOPUS:85115813446
SN - 1942-0900
VL - 2021
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
M1 - 6331630
ER -
