TY - JOUR
T1 - Therapeutic potential of α-and β-pinene
T2 - A miracle gift of nature
AU - Salehi, Bahare
AU - Upadhyay, Shashi
AU - Orhan, Ilkay Erdogan
AU - Jugran, Arun Kumar
AU - Jayaweera, Sumali L.D.
AU - Dias, Daniel A.
AU - Sharopov, Farukh
AU - Taheri, Yasaman
AU - Martins, Natália
AU - Baghalpour, Navid
AU - Cho, William C.
AU - Sharifi-Rad, Javad
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/11
Y1 - 2019/11
N2 - α-and β-pinene are well-known representatives of the monoterpenes group, and are found in many plants’ essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of α-and β-pinene, namely their cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects, as well as their effects against H2O2-stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain. Finally, we will also discuss the bioavailability, administration, as well as their biological activity and clinical applications.
AB - α-and β-pinene are well-known representatives of the monoterpenes group, and are found in many plants’ essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of α-and β-pinene, namely their cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects, as well as their effects against H2O2-stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain. Finally, we will also discuss the bioavailability, administration, as well as their biological activity and clinical applications.
KW - Bioavailability
KW - Clinical studies
KW - Cytotoxicity
KW - Pharmacological activities
KW - α-pinene
KW - β-pinene
UR - https://www.scopus.com/pages/publications/85075114981
U2 - 10.3390/biom9110738
DO - 10.3390/biom9110738
M3 - Artículo de revisión
C2 - 31739596
AN - SCOPUS:85075114981
SN - 2218-273X
VL - 9
JO - Biomolecules
JF - Biomolecules
IS - 11
M1 - 738
ER -