TY - JOUR
T1 - Therapeutic Applications of Curcumin in Diabetes
T2 - A Review and Perspective
AU - Quispe, Cristina
AU - Herrera-Bravo, Jesús
AU - Javed, Zeeshan
AU - Khan, Khushbukhat
AU - Raza, Shahid
AU - Gulsunoglu-Konuskan, Zehra
AU - Daştan, Sevgi Durna
AU - Sytar, Oksana
AU - Martorell, Miquel
AU - Sharifi-Rad, Javad
AU - Calina, Daniela
N1 - Publisher Copyright:
© 2022 Cristina Quispe et al.
PY - 2022
Y1 - 2022
N2 - Diabetes is a metabolic disease with multifactorial causes which requires lifelong drug therapy as well as lifestyle changes. There is now growing scientific evidence to support the effectiveness of the use of herbal supplements in the prevention and control of diabetes. Curcumin is one of the most studied bioactive components of traditional medicine, but its physicochemical characteristics are represented by low solubility, poor absorption, and low efficacy. Nanotechnology-based pharmaceutical formulations can help overcome the problems of reduced bioavailability of curcumin and increase its antidiabetic effects. The objectives of this review were to review the effects of nanocurcumin on DM and to search for databases such as PubMed/MEDLINE and ScienceDirect. The results showed that the antidiabetic activity of nanocurcumin is due to complex pharmacological mechanisms by reducing the characteristic hyperglycemia of DM. In light of these results, nanocurcumin may be considered as potential agent in the pharmacotherapeutic management of patients with diabetes.
AB - Diabetes is a metabolic disease with multifactorial causes which requires lifelong drug therapy as well as lifestyle changes. There is now growing scientific evidence to support the effectiveness of the use of herbal supplements in the prevention and control of diabetes. Curcumin is one of the most studied bioactive components of traditional medicine, but its physicochemical characteristics are represented by low solubility, poor absorption, and low efficacy. Nanotechnology-based pharmaceutical formulations can help overcome the problems of reduced bioavailability of curcumin and increase its antidiabetic effects. The objectives of this review were to review the effects of nanocurcumin on DM and to search for databases such as PubMed/MEDLINE and ScienceDirect. The results showed that the antidiabetic activity of nanocurcumin is due to complex pharmacological mechanisms by reducing the characteristic hyperglycemia of DM. In light of these results, nanocurcumin may be considered as potential agent in the pharmacotherapeutic management of patients with diabetes.
UR - https://www.scopus.com/pages/publications/85124618714
U2 - 10.1155/2022/1375892
DO - 10.1155/2022/1375892
M3 - Artículo de revisión
C2 - 35155670
AN - SCOPUS:85124618714
SN - 2314-6133
VL - 2022
JO - BioMed Research International
JF - BioMed Research International
M1 - 1375892
ER -
