TY - JOUR
T1 - The Therapeutic Potential of Wogonin Observed in Preclinical Studies
AU - Sharifi-Rad, Javad
AU - Herrera-Bravo, Jesús
AU - Salazar, Luis A.
AU - Shaheen, Shabnum
AU - Abdulmajid Ayatollahi, Seyed
AU - Kobarfard, Farzad
AU - Imran, Muhammad
AU - Imran, Ali
AU - Custódio, Luísa
AU - Dolores López, María
AU - Schoebitz, Mauricio
AU - Martorell, Miquel
AU - Kumar, Manoj
AU - Ansar Rasul Suleria, Hafiz
AU - Cho, William C.
N1 - Publisher Copyright:
© 2021 Javad Sharifi-Rad et al.
PY - 2021
Y1 - 2021
N2 - Wogonin is a flavonoid found in different plants such as roots of Scutellaria baicalensis Georgi distributed mainly in Asia and Europe. Dried root extracts of S. baicalensis with high content of wogonin, popularly known as "Huang-Qin"or Chinese or baical skullcap, have been used for long time in traditional Chinese medicine. Several health benefits are attributed to wogonin and derivatives showing anti-inflammatory, antiviral, anticancer, and antioxidant effects and more recently antineurodegenerative properties. Preclinical pharmacological activities of wogonin against diverse types of cancer such as breast, colorectal, and human gastric cancer will be presented in this review. In addition, studies on oxidative stress and bioavailability of wogonin will be discussed together with antineurodegenerative potential with special focus on Alzheimer's disease. Outcomes extracted from the last preclinical studies related to therapeutic applications of wogonin will be commented and updated in this review. The scientific evidence collected in this review aims to encourage transfer of the preclinical evidence of wogonin to new clinical studies.
AB - Wogonin is a flavonoid found in different plants such as roots of Scutellaria baicalensis Georgi distributed mainly in Asia and Europe. Dried root extracts of S. baicalensis with high content of wogonin, popularly known as "Huang-Qin"or Chinese or baical skullcap, have been used for long time in traditional Chinese medicine. Several health benefits are attributed to wogonin and derivatives showing anti-inflammatory, antiviral, anticancer, and antioxidant effects and more recently antineurodegenerative properties. Preclinical pharmacological activities of wogonin against diverse types of cancer such as breast, colorectal, and human gastric cancer will be presented in this review. In addition, studies on oxidative stress and bioavailability of wogonin will be discussed together with antineurodegenerative potential with special focus on Alzheimer's disease. Outcomes extracted from the last preclinical studies related to therapeutic applications of wogonin will be commented and updated in this review. The scientific evidence collected in this review aims to encourage transfer of the preclinical evidence of wogonin to new clinical studies.
UR - https://www.scopus.com/pages/publications/85116957879
U2 - 10.1155/2021/9935451
DO - 10.1155/2021/9935451
M3 - Artículo de revisión
AN - SCOPUS:85116957879
SN - 1741-427X
VL - 2021
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
M1 - 9935451
ER -
