TY - JOUR
T1 - The therapeutic potential of curcumin
T2 - A review of clinical trials
AU - Salehi, Bahare
AU - Stojanović-Radić, Zorica
AU - Matejić, Jelena
AU - Sharifi-Rad, Mehdi
AU - Anil Kumar, Nanjangud V.
AU - Martins, Natália
AU - Sharifi-Rad, Javad
N1 - Publisher Copyright:
© 2018
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Clinical trials, although have increased in a progressive manner, significant disproportionalities have been stated in terms of biological effects assessment. In this sense, the present report aims to provide an extensive overview to curcumin therapeutic effects in human subjects. For that, clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are here presented and discussed. A special emphasis was also given to curcumin activity on intoxications and multiple malignant diseases.
AB - Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Clinical trials, although have increased in a progressive manner, significant disproportionalities have been stated in terms of biological effects assessment. In this sense, the present report aims to provide an extensive overview to curcumin therapeutic effects in human subjects. For that, clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are here presented and discussed. A special emphasis was also given to curcumin activity on intoxications and multiple malignant diseases.
KW - Clinical trials
KW - Curcuma longa L.
KW - Curcuminoids
KW - Pharmacological effects
KW - Secondary metabolites
UR - https://www.scopus.com/pages/publications/85058169862
U2 - 10.1016/j.ejmech.2018.12.016
DO - 10.1016/j.ejmech.2018.12.016
M3 - Artículo de revisión
C2 - 30553144
AN - SCOPUS:85058169862
SN - 0223-5234
VL - 163
SP - 527
EP - 545
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
ER -
