The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies

Ruhul Amin; Cristina Quispe; Anca Oana Docea; Alibek Ydyrys; Marzhan Kulbayeva; Sevgi Durna Daştan; Daniela Calina; Javad Sharifi-Rad

doi:10.1016/j.neuint.2022.105376

The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies

Ruhul Amin
, Cristina Quispe
, Anca Oana Docea
, Alibek Ydyrys
, Marzhan Kulbayeva
, Sevgi Durna Daştan
, Daniela Calina
, Javad Sharifi-Rad

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

48 Citas (Scopus)

Resumen

Neurodegenerative disorders Parkinson's disease is a progressive neurodegenerative disorder associated with neuroinflammatory responses that lead to the neurodegeneration of the dopaminergic neurons. These neuroinflammatory mechanisms involve various cytokines produced by the activated glial cells. Tumour Necrosis factor α (TNF α) is one of the major mediators of the neuroinflammation associated with neurodegeneration. TNF α has a dual role of neuroprotection and neurotoxicity in the brain. The effective pathways of TNF involve various signalling pathways transduced by the receptors TNFR1 and TNFR2. Effective therapeutic strategies have been produced targeting the neurotoxic behaviour of the Tumour Necrosis Factor and the associated neurodegeneration which includes the use of Dominant Negative Tumour Necrosis Factor (DN-TNF) inhibitors like XENP 345 and XPro®1595 and peroxisome proliferator receptor gamma (PPAR-γ) agonists.

Idioma original	Inglés
Número de artículo	105376
Publicación	Neurochemistry International
Volumen	158
DOI	https://doi.org/10.1016/j.neuint.2022.105376
Estado	Publicada - sep. 2022
Publicado de forma externa	Sí

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title = "The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies",

abstract = "Neurodegenerative disorders Parkinson's disease is a progressive neurodegenerative disorder associated with neuroinflammatory responses that lead to the neurodegeneration of the dopaminergic neurons. These neuroinflammatory mechanisms involve various cytokines produced by the activated glial cells. Tumour Necrosis factor α (TNF α) is one of the major mediators of the neuroinflammation associated with neurodegeneration. TNF α has a dual role of neuroprotection and neurotoxicity in the brain. The effective pathways of TNF involve various signalling pathways transduced by the receptors TNFR1 and TNFR2. Effective therapeutic strategies have been produced targeting the neurotoxic behaviour of the Tumour Necrosis Factor and the associated neurodegeneration which includes the use of Dominant Negative Tumour Necrosis Factor (DN-TNF) inhibitors like XENP 345 and XPro{\textregistered}1595 and peroxisome proliferator receptor gamma (PPAR-γ) agonists.",

keywords = "Inflammation, Microglia, Neurodegeneration, Neuroinflammation, Parkinson's disease, TNF-α, TNF-α inhibitors",

author = "Ruhul Amin and Cristina Quispe and Docea, \{Anca Oana\} and Alibek Ydyrys and Marzhan Kulbayeva and \{Durna Da{\c s}tan\}, Sevgi and Daniela Calina and Javad Sharifi-Rad",

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doi = "10.1016/j.neuint.2022.105376",

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volume = "158",

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TY - JOUR

T1 - The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies

AU - Amin, Ruhul

AU - Quispe, Cristina

AU - Docea, Anca Oana

AU - Ydyrys, Alibek

AU - Kulbayeva, Marzhan

AU - Durna Daştan, Sevgi

AU - Calina, Daniela

AU - Sharifi-Rad, Javad

PY - 2022/9

Y1 - 2022/9

N2 - Neurodegenerative disorders Parkinson's disease is a progressive neurodegenerative disorder associated with neuroinflammatory responses that lead to the neurodegeneration of the dopaminergic neurons. These neuroinflammatory mechanisms involve various cytokines produced by the activated glial cells. Tumour Necrosis factor α (TNF α) is one of the major mediators of the neuroinflammation associated with neurodegeneration. TNF α has a dual role of neuroprotection and neurotoxicity in the brain. The effective pathways of TNF involve various signalling pathways transduced by the receptors TNFR1 and TNFR2. Effective therapeutic strategies have been produced targeting the neurotoxic behaviour of the Tumour Necrosis Factor and the associated neurodegeneration which includes the use of Dominant Negative Tumour Necrosis Factor (DN-TNF) inhibitors like XENP 345 and XPro®1595 and peroxisome proliferator receptor gamma (PPAR-γ) agonists.

AB - Neurodegenerative disorders Parkinson's disease is a progressive neurodegenerative disorder associated with neuroinflammatory responses that lead to the neurodegeneration of the dopaminergic neurons. These neuroinflammatory mechanisms involve various cytokines produced by the activated glial cells. Tumour Necrosis factor α (TNF α) is one of the major mediators of the neuroinflammation associated with neurodegeneration. TNF α has a dual role of neuroprotection and neurotoxicity in the brain. The effective pathways of TNF involve various signalling pathways transduced by the receptors TNFR1 and TNFR2. Effective therapeutic strategies have been produced targeting the neurotoxic behaviour of the Tumour Necrosis Factor and the associated neurodegeneration which includes the use of Dominant Negative Tumour Necrosis Factor (DN-TNF) inhibitors like XENP 345 and XPro®1595 and peroxisome proliferator receptor gamma (PPAR-γ) agonists.

KW - Inflammation

KW - Microglia

KW - Neurodegeneration

KW - Neuroinflammation

KW - Parkinson's disease

KW - TNF-α

KW - TNF-α inhibitors

UR - https://www.scopus.com/pages/publications/85131409426

U2 - 10.1016/j.neuint.2022.105376

DO - 10.1016/j.neuint.2022.105376

M3 - Artículo de revisión

C2 - 35667491

AN - SCOPUS:85131409426

SN - 0197-0186

VL - 158

JO - Neurochemistry International

JF - Neurochemistry International

M1 - 105376

ER -

The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies

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