TY - JOUR
T1 - Targeting androgen receptor signaling with MicroRNAs and Curcumin
T2 - a promising therapeutic approach for Prostate Cancer Prevention and intervention
AU - Javed, Zeeshan
AU - Khan, Khushbukhat
AU - Rasheed, Amna
AU - Sadia, Haleema
AU - Shahwani, Muhammad Naeem
AU - Irshad, Asma
AU - Raza, Shahid
AU - Salehi, Bahare
AU - Sharifi-Rad, Javad
AU - Suleria, Hafiz A.R.
AU - Cruz-Martins, Natália
AU - Quispe, Cristina
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Prostate cancer (PC) is a multifactorial disease characterized by the abrogation of androgen receptor signaling. Advancement in microbiology techniques has highlighted the significant role of microRNAs (miRNAs) in the progression of PC cells from an androgen-dependent to an androgen-independent state. At that stage, prostate tumors also fail to respond to currently practiced hormone therapies. So, studies in recent decades are focused on investigating the anti-tumor effects of natural compounds in PC. Curcumin is widely recognized and now of huge prestige for its anti-proliferative abilities in different types of cancer. However, its limited solubility, compatibility, and instability in the aqueous phase are major hurdles when administering. Nanoformulations have proven to be an excellent drug delivery system for various drugs and can be used as potential delivery platforms for curcumin in PC. In this review, a shed light is given on the miRNAs-mediated regulation of androgen receptor (AR) signaling and miRNA-curcumin interplay in PC, as well as on curcumin-based nanoformulations that can be used as possible therapeutic solutions for PC.
AB - Prostate cancer (PC) is a multifactorial disease characterized by the abrogation of androgen receptor signaling. Advancement in microbiology techniques has highlighted the significant role of microRNAs (miRNAs) in the progression of PC cells from an androgen-dependent to an androgen-independent state. At that stage, prostate tumors also fail to respond to currently practiced hormone therapies. So, studies in recent decades are focused on investigating the anti-tumor effects of natural compounds in PC. Curcumin is widely recognized and now of huge prestige for its anti-proliferative abilities in different types of cancer. However, its limited solubility, compatibility, and instability in the aqueous phase are major hurdles when administering. Nanoformulations have proven to be an excellent drug delivery system for various drugs and can be used as potential delivery platforms for curcumin in PC. In this review, a shed light is given on the miRNAs-mediated regulation of androgen receptor (AR) signaling and miRNA-curcumin interplay in PC, as well as on curcumin-based nanoformulations that can be used as possible therapeutic solutions for PC.
KW - Androgen receptor signaling
KW - Curcumin
KW - Diagnostic markers
KW - MicroRNAs
KW - Nanoformulations
KW - Prostate cancer
UR - https://www.scopus.com/pages/publications/85099861020
U2 - 10.1186/s12935-021-01777-3
DO - 10.1186/s12935-021-01777-3
M3 - Artículo de revisión
AN - SCOPUS:85099861020
SN - 1475-2867
VL - 21
JO - Cancer Cell International
JF - Cancer Cell International
IS - 1
M1 - 77
ER -
