TY - JOUR
T1 - TAP2 codon 651 (rs4148876) gene polymorphism and cervical cancer risk
T2 - a meta-analysis and trial sequence analysis
AU - Mandal, Raju K.
AU - Madkhali, Nora
AU - Mathkor, Darin M.
AU - Areeshi, Mohammed Y.
AU - Wahid, Mohd
AU - Dailah, Hamad G.
AU - Haque, Shafiul
N1 - Publisher Copyright:
© 2024 Edizioni Minerva Medica. All rights reserved.
PY - 2024
Y1 - 2024
N2 - INTRODUCTION: The transporter associated with antigen processing 2 (TAP2) gene is implicated in the MHC class I antigen processing and immune regulation. TAP2 rs4148876 polymorphism as a risk factor for cervical cancer (CC) risk has been investigated in many studies; however, with inconclusive results. A trial sequential meta-analysis was performed for a thorough evaluation of the relationship between TAP2 rs4148876 gene polymorphism and CC risk. EVIDENCE ACQUISITION: Medline (PubMed), EMBASE (Excerpta-Medica) and Google Scholar were used as sources for the selection of relevant articles about TAP2 rs4148876 gene polymorphism and CC risk. The significance of association between TAP2 rs4148876 and CC risk was determined using odds ratios (ORs) and 95% confidence intervals (CIs) estimation. Statistical I2 tests and sensitivity analyses were performed to detect inter study heterogeneity and test the statistical stability of the overall estimate association. Egger's test was used to detect the publication bias among included studies. EVIDENCE SYNTHESIS: The pooled analysis indicated significant risk for homozygous mutant (MM vs. WW: P=0.001; OR=3.744, 95% CI=1.972-7.106) and recessive (MM vs. WW+WM: P=0.001; OR=3.899, 95% CI=2.065-7.361) genetic models with CC. However, there was no association of allelic (M vs. W: P=0.544 OR =1.355, 95% CI = 0.507-3.623), heterozygous (MW vs. WW: P=0.730; OR=0.857, 95% CI=0.357-2.059) and dominant (MM+MW vs. WW: P=0.563; OR=1.321, 95% CI=0.514- 3.395) models with CC risk. The study showed no publication bias. CONCLUSIONS: Our results indicate a positive association of TAP2 rs414884 genetic variant with CC. This is the first step in establishing an effective risk prediction for CC, which may help us better identify and prevent the occurrence of CC. However, exhaustive prospective epidemiological studies are warranted to confirm TAP2 rs414884 polymorphism as a risk factor in the etiology of CC.
AB - INTRODUCTION: The transporter associated with antigen processing 2 (TAP2) gene is implicated in the MHC class I antigen processing and immune regulation. TAP2 rs4148876 polymorphism as a risk factor for cervical cancer (CC) risk has been investigated in many studies; however, with inconclusive results. A trial sequential meta-analysis was performed for a thorough evaluation of the relationship between TAP2 rs4148876 gene polymorphism and CC risk. EVIDENCE ACQUISITION: Medline (PubMed), EMBASE (Excerpta-Medica) and Google Scholar were used as sources for the selection of relevant articles about TAP2 rs4148876 gene polymorphism and CC risk. The significance of association between TAP2 rs4148876 and CC risk was determined using odds ratios (ORs) and 95% confidence intervals (CIs) estimation. Statistical I2 tests and sensitivity analyses were performed to detect inter study heterogeneity and test the statistical stability of the overall estimate association. Egger's test was used to detect the publication bias among included studies. EVIDENCE SYNTHESIS: The pooled analysis indicated significant risk for homozygous mutant (MM vs. WW: P=0.001; OR=3.744, 95% CI=1.972-7.106) and recessive (MM vs. WW+WM: P=0.001; OR=3.899, 95% CI=2.065-7.361) genetic models with CC. However, there was no association of allelic (M vs. W: P=0.544 OR =1.355, 95% CI = 0.507-3.623), heterozygous (MW vs. WW: P=0.730; OR=0.857, 95% CI=0.357-2.059) and dominant (MM+MW vs. WW: P=0.563; OR=1.321, 95% CI=0.514- 3.395) models with CC risk. The study showed no publication bias. CONCLUSIONS: Our results indicate a positive association of TAP2 rs414884 genetic variant with CC. This is the first step in establishing an effective risk prediction for CC, which may help us better identify and prevent the occurrence of CC. However, exhaustive prospective epidemiological studies are warranted to confirm TAP2 rs414884 polymorphism as a risk factor in the etiology of CC.
KW - Meta-analysis
KW - Polymorphism
KW - Uterine cervical neoplasms
KW - genetic
UR - https://www.scopus.com/pages/publications/85195639100
U2 - 10.23736/S2724-542X.24.02941-9
DO - 10.23736/S2724-542X.24.02941-9
M3 - Artículo de revisión
AN - SCOPUS:85195639100
SN - 2724-542X
VL - 36
SP - 74
EP - 80
JO - Minerva Biotechnology and Biomolecular Research
JF - Minerva Biotechnology and Biomolecular Research
IS - 2
ER -
