Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

Javad Sharifi-Rad; Cristina Quispe; Zhazira Mukazhanova; Ewa Knut; Aknur Turgumbayeva; Aliya Kipchakbayeva; Gulnaz Seitimova; Mohamad Fawzi Mahomoodally; Devina Lobine; Aaron Koay; Jinfan Wang; Helen Sheridan; Gerardo Leyva-Gómez; María L.Del Prado-Audelo; Hernán Cortes; Antonio Rescigno; Paolo Zucca; Oksana Sytar; Muhammad Imran; Célia F. Rodrigues; Natália Cruz-Martins; Halina Ekiert; Manoj Kumar; Ahmad Faizal Abdull Razis; Usman Sunusi; Ramla Muhammad Kamal; Agnieszka Szopa

doi:10.3389/fmolb.2021.649395

Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

Javad Sharifi-Rad
, Cristina Quispe
, Zhazira Mukazhanova
, Ewa Knut
, Aknur Turgumbayeva
, Aliya Kipchakbayeva
, Gulnaz Seitimova
, Mohamad Fawzi Mahomoodally
, Devina Lobine
, Aaron Koay
, Jinfan Wang
, Helen Sheridan
, Gerardo Leyva-Gómez
, María L.Del Prado-Audelo
, Hernán Cortes
, Antonio Rescigno
, Paolo Zucca
, Oksana Sytar
, Muhammad Imran
, Célia F. Rodrigues

Natália Cruz-Martins, Halina Ekiert, Manoj Kumar, Ahmad Faizal Abdull Razis, Usman Sunusi, Ramla Muhammad Kamal, Agnieszka Szopa

Shahid Beheshti University of Medical Sciences
Universidad Arturo Prat
Sarsen Amanzholov East Kazakhstan State University
Jagiellonian University Medical College
Kazakh National Medical University
Al Farabi Kazakh National University
University of Mauritius
Trinity College Dublin
Universidad Nacional Autónoma de México
Instituto Nacional de Rehabilitación
University of Cagliari
Kyiv National Taras Shevchenko University
Slovak University of Agriculture in Nitra
The University of Lahore
University of Porto
ICAR - Central Institute of Research on Cotton Technology
Universiti Putra Malaysia
Bayero University
Federal University Dutse

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

96 Citas (Scopus)

Resumen

Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.

Idioma original	Inglés
Número de artículo	649395
Publicación	Frontiers in Molecular Biosciences
Volumen	8
DOI	https://doi.org/10.3389/fmolb.2021.649395
Estado	Publicada - 1 sept 2021
Publicado de forma externa	Sí

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Sharifi-Rad, J., Quispe, C., Mukazhanova, Z., Knut, E., Turgumbayeva, A., Kipchakbayeva, A., Seitimova, G., Mahomoodally, M. F., Lobine, D., Koay, A., Wang, J., Sheridan, H., Leyva-Gómez, G., Prado-Audelo, M. L. D., Cortes, H., Rescigno, A., Zucca, P., Sytar, O., Imran, M., ... Szopa, A. (2021). Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer. Frontiers in Molecular Biosciences, 8, Artículo 649395. https://doi.org/10.3389/fmolb.2021.649395

@article{46dfeaac2319481da788b23ef18c3e53,

title = "Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer",

abstract = "Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.",

keywords = "bio-availability, cancer therapy, clinical applications, drug-delivery systems, resveratrol",

author = "Javad Sharifi-Rad and Cristina Quispe and Zhazira Mukazhanova and Ewa Knut and Aknur Turgumbayeva and Aliya Kipchakbayeva and Gulnaz Seitimova and Mahomoodally, \{Mohamad Fawzi\} and Devina Lobine and Aaron Koay and Jinfan Wang and Helen Sheridan and Gerardo Leyva-G{\'o}mez and Prado-Audelo, \{Mar{\'i}a L.Del\} and Hern{\'a}n Cortes and Antonio Rescigno and Paolo Zucca and Oksana Sytar and Muhammad Imran and Rodrigues, \{C{\'e}lia F.\} and Nat{\'a}lia Cruz-Martins and Halina Ekiert and Manoj Kumar and \{Abdull Razis\}, \{Ahmad Faizal\} and Usman Sunusi and Kamal, \{Ramla Muhammad\} and Agnieszka Szopa",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Sharifi-Rad, Quispe, Mukazhanova, Knut, Turgumbayeva, Kipchakbayeva, Seitimova, Mahomoodally, Lobine, Koay, Wang, Sheridan, Leyva-G{\'o}mez, Prado-Audelo, Cortes, Rescigno, Zucca, Sytar, Imran, Rodrigues, Cruz-Martins, Ekiert, Kumar, Abdull Razis, Sunusi, Kamal and Szopa.",

year = "2021",

month = sep,

day = "1",

doi = "10.3389/fmolb.2021.649395",

language = "Ingl{\'e}s",

volume = "8",

journal = "Frontiers in Molecular Biosciences",

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Sharifi-Rad, J, Quispe, C, Mukazhanova, Z, Knut, E, Turgumbayeva, A, Kipchakbayeva, A, Seitimova, G, Mahomoodally, MF, Lobine, D, Koay, A, Wang, J, Sheridan, H, Leyva-Gómez, G, Prado-Audelo, MLD, Cortes, H, Rescigno, A, Zucca, P, Sytar, O, Imran, M, Rodrigues, CF, Cruz-Martins, N, Ekiert, H, Kumar, M, Abdull Razis, AF, Sunusi, U, Kamal, RM & Szopa, A 2021, 'Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer', Frontiers in Molecular Biosciences, vol. 8, 649395. https://doi.org/10.3389/fmolb.2021.649395

TY - JOUR

T1 - Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

AU - Sharifi-Rad, Javad

AU - Quispe, Cristina

AU - Mukazhanova, Zhazira

AU - Knut, Ewa

AU - Turgumbayeva, Aknur

AU - Kipchakbayeva, Aliya

AU - Seitimova, Gulnaz

AU - Mahomoodally, Mohamad Fawzi

AU - Lobine, Devina

AU - Koay, Aaron

AU - Wang, Jinfan

AU - Sheridan, Helen

AU - Leyva-Gómez, Gerardo

AU - Prado-Audelo, María L.Del

AU - Cortes, Hernán

AU - Rescigno, Antonio

AU - Zucca, Paolo

AU - Sytar, Oksana

AU - Imran, Muhammad

AU - Rodrigues, Célia F.

AU - Cruz-Martins, Natália

AU - Ekiert, Halina

AU - Kumar, Manoj

AU - Abdull Razis, Ahmad Faizal

AU - Sunusi, Usman

AU - Kamal, Ramla Muhammad

AU - Szopa, Agnieszka

N1 - Publisher Copyright: © Copyright © 2021 Sharifi-Rad, Quispe, Mukazhanova, Knut, Turgumbayeva, Kipchakbayeva, Seitimova, Mahomoodally, Lobine, Koay, Wang, Sheridan, Leyva-Gómez, Prado-Audelo, Cortes, Rescigno, Zucca, Sytar, Imran, Rodrigues, Cruz-Martins, Ekiert, Kumar, Abdull Razis, Sunusi, Kamal and Szopa.

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.

AB - Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.

KW - bio-availability

KW - cancer therapy

KW - clinical applications

KW - drug-delivery systems

KW - resveratrol

UR - https://www.scopus.com/pages/publications/85115017819

U2 - 10.3389/fmolb.2021.649395

DO - 10.3389/fmolb.2021.649395

M3 - Artículo de revisión

AN - SCOPUS:85115017819

SN - 2296-889X

VL - 8

JO - Frontiers in Molecular Biosciences

JF - Frontiers in Molecular Biosciences

M1 - 649395

ER -

Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

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