TY - JOUR
T1 - Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
AU - Sharifi-Rad, Javad
AU - Quispe, Cristina
AU - Mukazhanova, Zhazira
AU - Knut, Ewa
AU - Turgumbayeva, Aknur
AU - Kipchakbayeva, Aliya
AU - Seitimova, Gulnaz
AU - Mahomoodally, Mohamad Fawzi
AU - Lobine, Devina
AU - Koay, Aaron
AU - Wang, Jinfan
AU - Sheridan, Helen
AU - Leyva-Gómez, Gerardo
AU - Prado-Audelo, María L.Del
AU - Cortes, Hernán
AU - Rescigno, Antonio
AU - Zucca, Paolo
AU - Sytar, Oksana
AU - Imran, Muhammad
AU - Rodrigues, Célia F.
AU - Cruz-Martins, Natália
AU - Ekiert, Halina
AU - Kumar, Manoj
AU - Abdull Razis, Ahmad Faizal
AU - Sunusi, Usman
AU - Kamal, Ramla Muhammad
AU - Szopa, Agnieszka
N1 - Publisher Copyright:
© Copyright © 2021 Sharifi-Rad, Quispe, Mukazhanova, Knut, Turgumbayeva, Kipchakbayeva, Seitimova, Mahomoodally, Lobine, Koay, Wang, Sheridan, Leyva-Gómez, Prado-Audelo, Cortes, Rescigno, Zucca, Sytar, Imran, Rodrigues, Cruz-Martins, Ekiert, Kumar, Abdull Razis, Sunusi, Kamal and Szopa.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.
AB - Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.
KW - bio-availability
KW - cancer therapy
KW - clinical applications
KW - drug-delivery systems
KW - resveratrol
UR - https://www.scopus.com/pages/publications/85115017819
U2 - 10.3389/fmolb.2021.649395
DO - 10.3389/fmolb.2021.649395
M3 - Artículo de revisión
AN - SCOPUS:85115017819
SN - 2296-889X
VL - 8
JO - Frontiers in Molecular Biosciences
JF - Frontiers in Molecular Biosciences
M1 - 649395
ER -
