TY - JOUR
T1 - Regulation of Hedgehog Signaling by miRNAs and Nanoformulations
T2 - A Possible Therapeutic Solution for Colorectal Cancer
AU - Javed, Zeeshan
AU - Javed Iqbal, Muhammad
AU - Rasheed, Amna
AU - Sadia, Haleema
AU - Raza, Shahid
AU - Irshad, Asma
AU - Koch, Wojciech
AU - Kukula-Koch, Wirginia
AU - Głowniak-Lipa, Anna
AU - Cho, William C.
AU - Sharifi-Rad, Javad
N1 - Publisher Copyright:
© Copyright © 2021 Javed, Javed Iqbal, Rasheed, Sadia, Raza, Irshad, Koch, Kukula-Koch, Głowniak-Lipa, Cho and Sharifi-Rad.
PY - 2021/1/7
Y1 - 2021/1/7
N2 - Hedgehog (Hh) signaling aberrations trigger differentiation and proliferation in colorectal cancer (CRC). However, the current approaches which inhibit this vital cellular pathway provoke some side effects. Therefore, it is necessary to look for new therapeutic options. MicroRNAs are small molecules that modulate expression of the target genes and can be utilized as a potential therapeutic option for CRC. On the other hand, nanoformulations have been implemented in the treatment of plethora of diseases. Owing to their excessive bioavailability, limited cytotoxicity and high specificity, nanoparticles may be considered as an alternative drug delivery platform for the Hh signaling mediated CRC. This article reviews the Hh signaling and its involvement in CRC with focus on miRNAs, nanoformulations as potential diagnostic/prognostic and therapeutics for CRC.
AB - Hedgehog (Hh) signaling aberrations trigger differentiation and proliferation in colorectal cancer (CRC). However, the current approaches which inhibit this vital cellular pathway provoke some side effects. Therefore, it is necessary to look for new therapeutic options. MicroRNAs are small molecules that modulate expression of the target genes and can be utilized as a potential therapeutic option for CRC. On the other hand, nanoformulations have been implemented in the treatment of plethora of diseases. Owing to their excessive bioavailability, limited cytotoxicity and high specificity, nanoparticles may be considered as an alternative drug delivery platform for the Hh signaling mediated CRC. This article reviews the Hh signaling and its involvement in CRC with focus on miRNAs, nanoformulations as potential diagnostic/prognostic and therapeutics for CRC.
KW - Hedgehog signaling
KW - colorectal cancer
KW - miRNAs
KW - nanoformulations
KW - nanoparticle
KW - therapeutics
UR - https://www.scopus.com/pages/publications/85099727960
U2 - 10.3389/fonc.2020.607607
DO - 10.3389/fonc.2020.607607
M3 - Artículo de revisión
AN - SCOPUS:85099727960
SN - 2234-943X
VL - 10
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 607607
ER -
