TY - JOUR
T1 - Preclinical pharmacological activities of epigallocatechin-3-gallate in signaling pathways
T2 - An update on cancer
AU - Sharifi-Rad, Mehdi
AU - Pezzani, Raffaele
AU - Redaelli, Marco
AU - Zorzan, Maira
AU - Imran, Muhammad
AU - Khalil, Anees Ahmed
AU - Salehi, Bahare
AU - Sharopov, Farukh
AU - Cho, William C.
AU - Sharifi-Rad, Javad
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
PY - 2020/1/22
Y1 - 2020/1/22
N2 - Epigallocatechin gallate (EGCG) is the main bioactive component of catechins predominantly present in svarious types of teas. EGCG is well known for a wide spectrum of biological activity as an anti-oxidative, anti-inflammatory, and anti-tumor agent. The effect of EGCG on cell death mechanisms via the induction of apoptosis, necrosis, and autophagy has been documented. Moreover, its anti-proliferative and chemopreventive action has been demonstrated in many cancer cell lines. It was also involved in the modulation of cyclooxygenase-2, in oxidative stress and inflammation of different cell processes. EGCG has been reported as a promising target for plasma membrane proteins, such as epidermal growth factor receptor (EGFR). In addition, it has been demonstrated a mechanism of action relying on the inhibition of ERK1/2, p38 MAPK, NF-κB, and vascular endothelial growth factor (VEGF). EGCG and its derivatives were used in proteasome inhibition and they were involved in epigenetic mechanisms. In summary, EGCG is the most predominant and bioactive constituent of teas and it has a pivotal role in cancer prevention. Its preclinical pharmacological activities are associated with complex molecular mechanisms that involve numerous signaling pathways.
AB - Epigallocatechin gallate (EGCG) is the main bioactive component of catechins predominantly present in svarious types of teas. EGCG is well known for a wide spectrum of biological activity as an anti-oxidative, anti-inflammatory, and anti-tumor agent. The effect of EGCG on cell death mechanisms via the induction of apoptosis, necrosis, and autophagy has been documented. Moreover, its anti-proliferative and chemopreventive action has been demonstrated in many cancer cell lines. It was also involved in the modulation of cyclooxygenase-2, in oxidative stress and inflammation of different cell processes. EGCG has been reported as a promising target for plasma membrane proteins, such as epidermal growth factor receptor (EGFR). In addition, it has been demonstrated a mechanism of action relying on the inhibition of ERK1/2, p38 MAPK, NF-κB, and vascular endothelial growth factor (VEGF). EGCG and its derivatives were used in proteasome inhibition and they were involved in epigenetic mechanisms. In summary, EGCG is the most predominant and bioactive constituent of teas and it has a pivotal role in cancer prevention. Its preclinical pharmacological activities are associated with complex molecular mechanisms that involve numerous signaling pathways.
KW - Cancer preventive
KW - Catechin
KW - EGCG
KW - Epigallocatechin-3-gallate
KW - Green tea
KW - Pharmacological activities
UR - https://www.scopus.com/pages/publications/85078316274
U2 - 10.3390/molecules25030467
DO - 10.3390/molecules25030467
M3 - Artículo de revisión
C2 - 31979082
AN - SCOPUS:85078316274
SN - 1420-3049
VL - 25
JO - Molecules
JF - Molecules
IS - 3
M1 - 467
ER -
