TY - JOUR
T1 - Plant natural products with anti-thyroid cancer activity
AU - Sharifi-Rad, Javad
AU - Rajabi, Sadegh
AU - Martorell, Miquel
AU - López, Maria Dolores
AU - Toro, María Trinidad
AU - Barollo, Susi
AU - Armanini, Decio
AU - Fokou, Patrick Valere Tsouh
AU - Zagotto, Giuseppe
AU - Ribaudo, Giovanni
AU - Pezzani, Raffaele
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/10
Y1 - 2020/10
N2 - Thyroid cancer is the most frequent endocrine malignancy, with more than 500,000 cases per year worldwide. Differentiated thyroid cancers are the most common forms with best prognosis, while poorly/undifferentiated ones are rare (2% of all thyroid cancer), aggressive, frequently metastasize and have a worse prognosis. For aggressive, metastatic and advanced thyroid cancer novel antitumor molecules are urgently needed and phytochemical products can be a rational and extensive source, since secondary plant metabolites can guarantee the necessary biochemical variability for therapeutic purpose. Among bioactive molecules that present biological activity on thyroid cancer, resveratrol, curcumin, isoflavones, glucosinolates are the most common and used in experimental model. Most of them have been studied both in vitro and in vivo on this cancer, but rarely in clinical trial. This review summarizes phytochemicals, phytotherapeutics and plant derived compounds used in thyroid cancer.
AB - Thyroid cancer is the most frequent endocrine malignancy, with more than 500,000 cases per year worldwide. Differentiated thyroid cancers are the most common forms with best prognosis, while poorly/undifferentiated ones are rare (2% of all thyroid cancer), aggressive, frequently metastasize and have a worse prognosis. For aggressive, metastatic and advanced thyroid cancer novel antitumor molecules are urgently needed and phytochemical products can be a rational and extensive source, since secondary plant metabolites can guarantee the necessary biochemical variability for therapeutic purpose. Among bioactive molecules that present biological activity on thyroid cancer, resveratrol, curcumin, isoflavones, glucosinolates are the most common and used in experimental model. Most of them have been studied both in vitro and in vivo on this cancer, but rarely in clinical trial. This review summarizes phytochemicals, phytotherapeutics and plant derived compounds used in thyroid cancer.
KW - Anaplastic thyroid cancer
KW - Follicular thyroid cancer
KW - Medullary thyroid cancer
KW - Papillary thyroid cancer
KW - Phytochemicals
KW - Phytotherapeutics
KW - Phytotherapy
KW - Plant extracts
KW - Plant natural products
KW - Thyroid cancer
UR - https://www.scopus.com/pages/publications/85086374172
U2 - 10.1016/j.fitote.2020.104640
DO - 10.1016/j.fitote.2020.104640
M3 - Artículo de revisión
C2 - 32474055
AN - SCOPUS:85086374172
SN - 0367-326X
VL - 146
JO - Fitoterapia
JF - Fitoterapia
M1 - 104640
ER -
