Phytotherapeutics in cancer invasion and metastasis

Bahare Salehi; Paolo Zucca; Mehdi Sharifi-Rad; Raffaele Pezzani; Sadegh Rajabi; William N. Setzer; Elena Maria Varoni; Marcello Iriti; Farzad Kobarfard; Javad Sharifi-Rad

doi:10.1002/ptr.6087

Phytotherapeutics in cancer invasion and metastasis

Bahare Salehi
, Paolo Zucca
, Mehdi Sharifi-Rad
, Raffaele Pezzani
, Sadegh Rajabi
, William N. Setzer
, Elena Maria Varoni
, Marcello Iriti
, Farzad Kobarfard
, Javad Sharifi-Rad

Shahid Beheshti University of Medical Sciences
University of Cagliari
Zabol University of Medical Sciences
University of Padua
Associazione Italiana per la Ricerca Oncologica di Base
University of Alabama in Huntsville
University of Milan
University of Winnipeg

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

125 Citas (Scopus)

Resumen

Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.

Idioma original	Inglés
Páginas (desde-hasta)	1425-1449
Número de páginas	25
Publicación	Phytotherapy Research
Volumen	32
N.º	8
DOI	https://doi.org/10.1002/ptr.6087
Estado	Publicada - ago 2018
Publicado de forma externa	Sí

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Acceder al documento

10.1002/ptr.6087

Otros archivos y enlaces

Enlace a la publicación en Scopus

Citar esto

@article{a2df5960e75d409e8af1094d1587fdb5,

title = "Phytotherapeutics in cancer invasion and metastasis",

abstract = "Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.",

keywords = "adjuvant therapy, anticancer drugs, cancer chemoprevention, chemotherapy, phytochemicals, plant products",

author = "Bahare Salehi and Paolo Zucca and Mehdi Sharifi-Rad and Raffaele Pezzani and Sadegh Rajabi and Setzer, \{William N.\} and Varoni, \{Elena Maria\} and Marcello Iriti and Farzad Kobarfard and Javad Sharifi-Rad",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 John Wiley \& Sons, Ltd.",

year = "2018",

month = aug,

doi = "10.1002/ptr.6087",

language = "Ingl{\'e}s",

volume = "32",

pages = "1425--1449",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

number = "8",

}

TY - JOUR

T1 - Phytotherapeutics in cancer invasion and metastasis

AU - Salehi, Bahare

AU - Zucca, Paolo

AU - Sharifi-Rad, Mehdi

AU - Pezzani, Raffaele

AU - Rajabi, Sadegh

AU - Setzer, William N.

AU - Varoni, Elena Maria

AU - Iriti, Marcello

AU - Kobarfard, Farzad

AU - Sharifi-Rad, Javad

PY - 2018/8

Y1 - 2018/8

N2 - Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.

AB - Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.

KW - adjuvant therapy

KW - anticancer drugs

KW - cancer chemoprevention

KW - chemotherapy

KW - phytochemicals

KW - plant products

UR - https://www.scopus.com/pages/publications/85047087260

U2 - 10.1002/ptr.6087

DO - 10.1002/ptr.6087

M3 - Artículo de revisión

C2 - 29672977

AN - SCOPUS:85047087260

SN - 0951-418X

VL - 32

SP - 1425

EP - 1449

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 8

ER -

Phytotherapeutics in cancer invasion and metastasis

Resumen

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto