Phytotherapeutics in cancer invasion and metastasis

Bahare Salehi; Paolo Zucca; Mehdi Sharifi-Rad; Raffaele Pezzani; Sadegh Rajabi; William N. Setzer; Elena Maria Varoni; Marcello Iriti; Farzad Kobarfard; Javad Sharifi-Rad

doi:10.1002/ptr.6087

Phytotherapeutics in cancer invasion and metastasis

Bahare Salehi, Paolo Zucca, Mehdi Sharifi-Rad, Raffaele Pezzani, Sadegh Rajabi, William N. Setzer, Elena Maria Varoni, Marcello Iriti, Farzad Kobarfard, Javad Sharifi-Rad

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

120 Citas (Scopus)

Resumen

Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.

Idioma original	Inglés
Páginas (desde-hasta)	1425-1449
Número de páginas	25
Publicación	Phytotherapy Research
Volumen	32
N.º	8
DOI	https://doi.org/10.1002/ptr.6087
Estado	Publicada - ago. 2018
Publicado de forma externa	Sí

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title = "Phytotherapeutics in cancer invasion and metastasis",

abstract = "Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.",

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AU - Salehi, Bahare

AU - Zucca, Paolo

AU - Sharifi-Rad, Mehdi

AU - Pezzani, Raffaele

AU - Rajabi, Sadegh

AU - Setzer, William N.

AU - Varoni, Elena Maria

AU - Iriti, Marcello

AU - Kobarfard, Farzad

AU - Sharifi-Rad, Javad

PY - 2018/8

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N2 - Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.

AB - Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.

KW - adjuvant therapy

KW - anticancer drugs

KW - cancer chemoprevention

KW - chemotherapy

KW - phytochemicals

KW - plant products

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AN - SCOPUS:85047087260

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JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 8

ER -

Phytotherapeutics in cancer invasion and metastasis

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