Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Javad Sharifi-Rad; Veronique Seidel; Michalak Izabela; Margalida Monserrat-Mequida; Antoni Sureda; Valeska Ormazabal; Felipe A. Zuniga; Shivaprasad Shetty Mangalpady; Raffaele Pezzani; Alibek Ydyrys; Gulmira Tussupbekova; Miquel Martorell; Daniela Calina; William C. Cho

doi:10.1186/s12964-023-01109-0

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Javad Sharifi-Rad
, Veronique Seidel
, Michalak Izabela
, Margalida Monserrat-Mequida
, Antoni Sureda
, Valeska Ormazabal
, Felipe A. Zuniga
, Shivaprasad Shetty Mangalpady
, Raffaele Pezzani
, Alibek Ydyrys
, Gulmira Tussupbekova
, Miquel Martorell
, Daniela Calina
, William C. Cho

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

63 Citas (Scopus)

Resumen

Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. [MediaObject not available: see fulltext.]

Idioma original	Inglés
Número de artículo	89
Publicación	Cell Communication and Signaling
Volumen	21
N.º	1
DOI	https://doi.org/10.1186/s12964-023-01109-0
Estado	Publicada - dic. 2023
Publicado de forma externa	Sí

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Sharifi-Rad, J., Seidel, V., Izabela, M., Monserrat-Mequida, M., Sureda, A., Ormazabal, V., Zuniga, F. A., Mangalpady, S. S., Pezzani, R., Ydyrys, A., Tussupbekova, G., Martorell, M., Calina, D., & Cho, W. C. (2023). Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy. Cell Communication and Signaling, 21(1), Artículo 89. https://doi.org/10.1186/s12964-023-01109-0

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title = "Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy",

abstract = "Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. [MediaObject not available: see fulltext.]",

keywords = "Apoptosis, Cancer, Cytotoxicity, Nrf2, Oxidative stress, Phenolic compounds",

author = "Javad Sharifi-Rad and Veronique Seidel and Michalak Izabela and Margalida Monserrat-Mequida and Antoni Sureda and Valeska Ormazabal and Zuniga, \{Felipe A.\} and Mangalpady, \{Shivaprasad Shetty\} and Raffaele Pezzani and Alibek Ydyrys and Gulmira Tussupbekova and Miquel Martorell and Daniela Calina and Cho, \{William C.\}",

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year = "2023",

month = dec,

doi = "10.1186/s12964-023-01109-0",

language = "Ingl{\'e}s",

volume = "21",

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Sharifi-Rad, J, Seidel, V, Izabela, M, Monserrat-Mequida, M, Sureda, A, Ormazabal, V, Zuniga, FA, Mangalpady, SS, Pezzani, R, Ydyrys, A, Tussupbekova, G, Martorell, M, Calina, D & Cho, WC 2023, 'Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy', Cell Communication and Signaling, vol. 21, n.º 1, 89. https://doi.org/10.1186/s12964-023-01109-0

TY - JOUR

T1 - Phenolic compounds as Nrf2 inhibitors

T2 - potential applications in cancer therapy

AU - Sharifi-Rad, Javad

AU - Seidel, Veronique

AU - Izabela, Michalak

AU - Monserrat-Mequida, Margalida

AU - Sureda, Antoni

AU - Ormazabal, Valeska

AU - Zuniga, Felipe A.

AU - Mangalpady, Shivaprasad Shetty

AU - Pezzani, Raffaele

AU - Ydyrys, Alibek

AU - Tussupbekova, Gulmira

AU - Martorell, Miquel

AU - Calina, Daniela

AU - Cho, William C.

PY - 2023/12

Y1 - 2023/12

N2 - Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. [MediaObject not available: see fulltext.]

AB - Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. [MediaObject not available: see fulltext.]

KW - Apoptosis

KW - Cancer

KW - Cytotoxicity

KW - Nrf2

KW - Oxidative stress

KW - Phenolic compounds

UR - https://www.scopus.com/pages/publications/85157976201

U2 - 10.1186/s12964-023-01109-0

DO - 10.1186/s12964-023-01109-0

M3 - Artículo de revisión

C2 - 37127651

AN - SCOPUS:85157976201

SN - 1478-811X

VL - 21

JO - Cell Communication and Signaling

JF - Cell Communication and Signaling

IS - 1

M1 - 89

ER -

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

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