TY - JOUR
T1 - Oridonin from Rabdosia rubescens
T2 - An emerging potential in cancer therapy – A comprehensive review
AU - Ali, Muhammad Asif
AU - Khan, Noohela
AU - Ali, Ahmad
AU - Akram, Hira
AU - Zafar, Noushaba
AU - Imran, Kinza
AU - Khan, Tooba
AU - Khan, Khushbukhat
AU - Armaghan, Muhammad
AU - Palma-Morales, Marta
AU - Rodríguez-Pérez, Celia
AU - Caunii, Angela
AU - Butnariu, Monica
AU - Habtemariam, Solomon
AU - Sharifi-Rad, Javad
N1 - Publisher Copyright:
© 2024 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
PY - 2024/5
Y1 - 2024/5
N2 - Cancer incidences are rising each year. In 2020, approximately 20 million new cancer cases and 10 million cancer-related deaths were recorded. The World Health Organization (WHO) predicts that by 2024 the incidence of cancer will increase to 30.2 million individuals annually. Considering the invasive characteristics of its diagnostic procedures and therapeutic methods side effects, scientists are searching for different solutions, including using plant-derived bioactive compounds, that could reduce the probability of cancer occurrence and make its treatment more comfortable. In this regard, oridonin (ORI), an ent-kaurane diterpenoid, naturally found in the leaves of Rabdosia rubescens species, has been found to have antitumor, antiangiogenesis, antiasthmatic, antiinflammatory, and apoptosis induction properties. Extensive research has been performed on ORI to find various mechanisms involved in its anticancer activities. This review article provides an overview of ORI's effectiveness on murine and human cancer populations from 1976 to 2022 and provides insight into the future application of ORI in different cancer therapies.
AB - Cancer incidences are rising each year. In 2020, approximately 20 million new cancer cases and 10 million cancer-related deaths were recorded. The World Health Organization (WHO) predicts that by 2024 the incidence of cancer will increase to 30.2 million individuals annually. Considering the invasive characteristics of its diagnostic procedures and therapeutic methods side effects, scientists are searching for different solutions, including using plant-derived bioactive compounds, that could reduce the probability of cancer occurrence and make its treatment more comfortable. In this regard, oridonin (ORI), an ent-kaurane diterpenoid, naturally found in the leaves of Rabdosia rubescens species, has been found to have antitumor, antiangiogenesis, antiasthmatic, antiinflammatory, and apoptosis induction properties. Extensive research has been performed on ORI to find various mechanisms involved in its anticancer activities. This review article provides an overview of ORI's effectiveness on murine and human cancer populations from 1976 to 2022 and provides insight into the future application of ORI in different cancer therapies.
KW - ORI
KW - anticancer properties
KW - cancer treatment
KW - diterpenoid
KW - natural compound
UR - https://www.scopus.com/pages/publications/85184244019
U2 - 10.1002/fsn3.3986
DO - 10.1002/fsn3.3986
M3 - Artículo de revisión
AN - SCOPUS:85184244019
SN - 2048-7177
VL - 12
SP - 3046
EP - 3067
JO - Food Science and Nutrition
JF - Food Science and Nutrition
IS - 5
ER -
