TY - JOUR
T1 - Neuropharmacological Effects of Quercetin
T2 - A Literature-Based Review
AU - Islam, Md Shahazul
AU - Quispe, Cristina
AU - Hossain, Rajib
AU - Islam, Muhammad Torequl
AU - Al-Harrasi, Ahmed
AU - Al-Rawahi, Ahmed
AU - Martorell, Miquel
AU - Mamurova, Assem
AU - Seilkhan, Ainur
AU - Altybaeva, Nazgul
AU - Abdullayeva, Bagila
AU - Docea, Anca Oana
AU - Calina, Daniela
AU - Sharifi-Rad, Javad
N1 - Publisher Copyright:
© Copyright © 2021 Islam, Quispe, Hossain, Islam, Al-Harrasi, Al-Rawahi, Martorell, Mamurova, Seilkhan, Altybaeva, Abdullayeva, Docea, Calina and Sharifi-Rad.
PY - 2021/6/17
Y1 - 2021/6/17
N2 - Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its beneficial properties in many pathologies. Its neuroprotective effects have been demonstrated in many in vitro studies, as well as in vivo animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer’s disease, Amyloid β peptide, Parkinson’s disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases.
AB - Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its beneficial properties in many pathologies. Its neuroprotective effects have been demonstrated in many in vitro studies, as well as in vivo animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer’s disease, Amyloid β peptide, Parkinson’s disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases.
KW - mechanisms
KW - neural damage
KW - neurodegenerative disorders
KW - neuropharmacological effects
KW - quercetin
KW - signaling pathways
UR - https://www.scopus.com/pages/publications/85109163141
U2 - 10.3389/fphar.2021.665031
DO - 10.3389/fphar.2021.665031
M3 - Artículo de revisión
AN - SCOPUS:85109163141
SN - 1663-9812
VL - 12
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 665031
ER -
