TY - JOUR
T1 - Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide
AU - Hossain, Rajib
AU - Quispe, Cristina
AU - Herrera-Bravo, Jesús
AU - Beltrán, Jorge F.
AU - Islam, Muhammad Torequl
AU - Shaheen, Shabnum
AU - Cruz-Martins, Natália
AU - Martorell, Miquel
AU - Kumar, Manoj
AU - Sharifi-Rad, Javad
AU - Ozdemir, Fethi Ahmet
AU - Setzer, William N.
AU - Alshehri, Mohammed M.
AU - Calina, Daniela
AU - Cho, William C.
N1 - Publisher Copyright:
© 2022 Rajib Hossain et al.
PY - 2022
Y1 - 2022
N2 - Andrographolide (ANDRO), a bitter diterpene lactone found in Andrographis paniculata (Burm.f.) Nees, possesses several biological effects such as antioxidant, anti-inflammatory, and organo-protective effects. Scientific reports suggest that it also has neuroprotective capacity in various test systems. The purpose of this review was to synthesize the neuropharmacological properties of ANDRO and highlight the molecular mechanisms of action that highlight these activities. A careful search was done in PubMed and Google Scholar databases using specific keywords. Findings suggest that ANDRO possess neuroprotective, analgesic, and antifatigue effects. Prominent effects were stated on neuro-inflammation, cerebral ischemia, Alzheimer's and Parkinson's diseases, multiple sclerosis, and brain cancer in mice and rats. Furthermore, ANDRO and its derivatives can enhance memory and learning capacity in experimental animals (rats) without causing any toxicity in the brain. Thus, ANDRO may be one of the most promising plant-based psychopharmacological lead compounds for new drug development.
AB - Andrographolide (ANDRO), a bitter diterpene lactone found in Andrographis paniculata (Burm.f.) Nees, possesses several biological effects such as antioxidant, anti-inflammatory, and organo-protective effects. Scientific reports suggest that it also has neuroprotective capacity in various test systems. The purpose of this review was to synthesize the neuropharmacological properties of ANDRO and highlight the molecular mechanisms of action that highlight these activities. A careful search was done in PubMed and Google Scholar databases using specific keywords. Findings suggest that ANDRO possess neuroprotective, analgesic, and antifatigue effects. Prominent effects were stated on neuro-inflammation, cerebral ischemia, Alzheimer's and Parkinson's diseases, multiple sclerosis, and brain cancer in mice and rats. Furthermore, ANDRO and its derivatives can enhance memory and learning capacity in experimental animals (rats) without causing any toxicity in the brain. Thus, ANDRO may be one of the most promising plant-based psychopharmacological lead compounds for new drug development.
UR - https://www.scopus.com/pages/publications/85124601462
U2 - 10.1155/2022/3079577
DO - 10.1155/2022/3079577
M3 - Artículo de revisión
C2 - 35154564
AN - SCOPUS:85124601462
SN - 1942-0900
VL - 2022
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
M1 - 3079577
ER -
