TY - JOUR
T1 - Neurobiological effects of gallic acid
T2 - current perspectives
AU - Bhuia, Md Shimul
AU - Rahaman, Md Mizanur
AU - Islam, Tawhida
AU - Bappi, Mehedi Hasan
AU - Sikder, Md Iqbal
AU - Hossain, Kazi Nadim
AU - Akter, Fatama
AU - Al Shamsh Prottay, Abdullah
AU - Rokonuzzman, Md
AU - Gürer, Eda Sönmez
AU - Calina, Daniela
AU - Islam, Muhammad Torequl
AU - Sharifi-Rad, Javad
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in medicinal plants. It has many health benefits due to its antioxidant properties. This study focused on finding out the neurobiological effects and mechanisms of GA using published data from reputed databases. For this, data were collected from various sources, such as PubMed/Medline, Science Direct, Scopus, Google Scholar, SpringerLink, and Web of Science. The findings suggest that GA can be used to manage several neurological diseases and disorders, such as Alzheimer’s disease, Parkinson’s disease, strokes, sedation, depression, psychosis, neuropathic pain, anxiety, and memory loss, as well as neuroinflammation. According to database reports and this current literature-based study, GA may be considered one of the potential lead compounds to treat neurological diseases and disorders. More preclinical and clinical studies are required to establish GA as a neuroprotective drug.
AB - Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in medicinal plants. It has many health benefits due to its antioxidant properties. This study focused on finding out the neurobiological effects and mechanisms of GA using published data from reputed databases. For this, data were collected from various sources, such as PubMed/Medline, Science Direct, Scopus, Google Scholar, SpringerLink, and Web of Science. The findings suggest that GA can be used to manage several neurological diseases and disorders, such as Alzheimer’s disease, Parkinson’s disease, strokes, sedation, depression, psychosis, neuropathic pain, anxiety, and memory loss, as well as neuroinflammation. According to database reports and this current literature-based study, GA may be considered one of the potential lead compounds to treat neurological diseases and disorders. More preclinical and clinical studies are required to establish GA as a neuroprotective drug.
KW - Brain health
KW - Gallic acid; neuroprotective activity; pharmacological effects
KW - Molecular mechanisms
UR - https://www.scopus.com/pages/publications/85150718266
U2 - 10.1186/s13020-023-00735-7
DO - 10.1186/s13020-023-00735-7
M3 - Artículo de revisión
AN - SCOPUS:85150718266
SN - 1749-8546
VL - 18
JO - Chinese Medicine (United Kingdom)
JF - Chinese Medicine (United Kingdom)
IS - 1
M1 - 27
ER -