TY - JOUR
T1 - Myricetin
T2 - targeting signaling networks in cancer and its implication in chemotherapy
AU - Javed, Zeeshan
AU - Khan, Khushbukhat
AU - Herrera-Bravo, Jesús
AU - Naeem, Sajid
AU - Iqbal, Muhammad Javed
AU - Raza, Qamar
AU - Sadia, Haleema
AU - Raza, Shahid
AU - Bhinder, Munir
AU - Calina, Daniela
AU - Sharifi-Rad, Javad
AU - Cho, William C.
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - The gaps between the complex nature of cancer and therapeutics have been narrowed down due to extensive research in molecular oncology. Despite gathering massive insight into the mysteries of tumor heterogeneity and the molecular framework of tumor cells, therapy resistance and adverse side effects of current therapeutic remain the major challenge. This has shifted the attention towards therapeutics with less toxicity and high efficacy. Myricetin a natural flavonoid has been under the spotlight for its anti-cancer, anti-oxidant, and anti-inflammatory properties. The cutting-edge molecular techniques have shed light on the interplay between myricetin and dysregulated signaling cascades in cancer progression, invasion, and metastasis. However, there are limited data available regarding the nano-delivery platforms composed of myricetin in cancer. In this review, we have provided a comprehensive detail of myricetin-mediated regulation of different cellular pathways, its implications in cancer prevention, preclinical and clinical trials, and its current available nano-formulations for the treatment of various cancers.
AB - The gaps between the complex nature of cancer and therapeutics have been narrowed down due to extensive research in molecular oncology. Despite gathering massive insight into the mysteries of tumor heterogeneity and the molecular framework of tumor cells, therapy resistance and adverse side effects of current therapeutic remain the major challenge. This has shifted the attention towards therapeutics with less toxicity and high efficacy. Myricetin a natural flavonoid has been under the spotlight for its anti-cancer, anti-oxidant, and anti-inflammatory properties. The cutting-edge molecular techniques have shed light on the interplay between myricetin and dysregulated signaling cascades in cancer progression, invasion, and metastasis. However, there are limited data available regarding the nano-delivery platforms composed of myricetin in cancer. In this review, we have provided a comprehensive detail of myricetin-mediated regulation of different cellular pathways, its implications in cancer prevention, preclinical and clinical trials, and its current available nano-formulations for the treatment of various cancers.
KW - Apoptosis
KW - Cancer
KW - Cell cycle
KW - Myricetin
KW - Nano-delivery
KW - Signaling networks
UR - https://www.scopus.com/pages/publications/85135596557
U2 - 10.1186/s12935-022-02663-2
DO - 10.1186/s12935-022-02663-2
M3 - Artículo de revisión
AN - SCOPUS:85135596557
SN - 1475-2867
VL - 22
JO - Cancer Cell International
JF - Cancer Cell International
IS - 1
M1 - 239
ER -
