Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

Andrea Strakova; Máire Ní Leathlobhair; Guo Dong Wang; Ting Ting Yin; Ilona Airikkala-Otter; Janice L. Allen; Karen M. Allum; Leontine Bansse-Issa; Jocelyn L. Bisson; Artemio Castillo Domracheva; Karina F. De Castro; Anne M. Corrigan; Hugh R. Cran; Jane T. Crawford; Stephen M. Cutter; Laura Delgadillo Keenan; Edward M. Donelan; Ibikunle A. Faramade; Erika Flores Reynoso; Eleni Fotopoulou; Skye N. Fruean; Fanny Gallardo-Arrieta; Olga Glebova; Rodrigo F. Häfelin Manrique; Joaquim J.G.P. Henriques; Natalia Ignatenko; Debbie Koenig; Marta Lanza-Perea; Remo Lobetti; Adriana M. Lopezquintana; Thibault Losfelt; Gabriele Marino; Inigo Martincorena; Simón Martínez Castañeda; Mayra F. Martínez-López; Michael Meyer; Berna Nakanwagi; Andrigo B. De Nardi; Winifred Neunzig; Sally J. Nixon; Marsden M. Onsare; Antonio Ortega-Pacheco; Maria C. Peleteiro; Ruth J. Pye; John F. Reece; Jose Rojas Gutierrez; Haleema Sadia; Sheila K. Schmeling; Olga Shamanova; Richard K. Ssuna; Audrey E.Alla Steenland-Smitsvitich; Ismail Thoya Ngoka; Bogdan A. Vitǎlaru; Anna P. De Vos; Johan P. De Vos; Oliver Walkinton; David C. Wedge; Alvaro S. Wehrle-Martinez; Mirjam G. Van Der Wel; Sophie Ae Widdowson; Elizabeth P. Murchison

doi:10.7554/eLife.14552

Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

Andrea Strakova, Máire Ní Leathlobhair, Guo Dong Wang, Ting Ting Yin, Ilona Airikkala-Otter, Janice L. Allen, Karen M. Allum, Leontine Bansse-Issa, Jocelyn L. Bisson, Artemio Castillo Domracheva, Karina F. De Castro, Anne M. Corrigan, Hugh R. Cran, Jane T. Crawford, Stephen M. Cutter, Laura Delgadillo Keenan, Edward M. Donelan, Ibikunle A. Faramade, Erika Flores Reynoso, Eleni FotopoulouSkye N. Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Rodrigo F. Häfelin Manrique, Joaquim J.G.P. Henriques, Natalia Ignatenko, Debbie Koenig, Marta Lanza-Perea, Remo Lobetti, Adriana M. Lopezquintana, Thibault Losfelt, Gabriele Marino, Inigo Martincorena, Simón Martínez Castañeda, Mayra F. Martínez-López, Michael Meyer, Berna Nakanwagi, Andrigo B. De Nardi, Winifred Neunzig, Sally J. Nixon, Marsden M. Onsare, Antonio Ortega-Pacheco, Maria C. Peleteiro, Ruth J. Pye, John F. Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K. Schmeling, Olga Shamanova, Richard K. Ssuna, Audrey E.Alla Steenland-Smitsvitich, Ismail Thoya Ngoka, Bogdan A. Vitǎlaru, Anna P. De Vos, Johan P. De Vos, Oliver Walkinton, David C. Wedge, Alvaro S. Wehrle-Martinez, Mirjam G. Van Der Wel, Sophie Ae Widdowson, Elizabeth P. Murchison

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Resumen

Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.

Idioma original	Inglés
Número de artículo	e14552
Publicación	eLife
Volumen	5
N.º	MAY2016
DOI	https://doi.org/10.7554/eLife.14552
Estado	Publicada - 17 may. 2016
Publicado de forma externa	Sí

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Strakova, A., Leathlobhair, M. N., Wang, G. D., Yin, T. T., Airikkala-Otter, I., Allen, J. L., Allum, K. M., Bansse-Issa, L., Bisson, J. L., Domracheva, A. C., De Castro, K. F., Corrigan, A. M., Cran, H. R., Crawford, J. T., Cutter, S. M., Keenan, L. D., Donelan, E. M., Faramade, I. A., Reynoso, E. F., ... Murchison, E. P. (2016). Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer. eLife, 5(MAY2016), Artículo e14552. https://doi.org/10.7554/eLife.14552

@article{cacb34afc8734f619fa980c3051a277e,

title = "Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer",

abstract = "Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.",

author = "Andrea Strakova and Leathlobhair, \{M{\'a}ire N{\'i}\} and Wang, \{Guo Dong\} and Yin, \{Ting Ting\} and Ilona Airikkala-Otter and Allen, \{Janice L.\} and Allum, \{Karen M.\} and Leontine Bansse-Issa and Bisson, \{Jocelyn L.\} and Domracheva, \{Artemio Castillo\} and \{De Castro\}, \{Karina F.\} and Corrigan, \{Anne M.\} and Cran, \{Hugh R.\} and Crawford, \{Jane T.\} and Cutter, \{Stephen M.\} and Keenan, \{Laura Delgadillo\} and Donelan, \{Edward M.\} and Faramade, \{Ibikunle A.\} and Reynoso, \{Erika Flores\} and Eleni Fotopoulou and Fruean, \{Skye N.\} and Fanny Gallardo-Arrieta and Olga Glebova and \{H{\"a}felin Manrique\}, \{Rodrigo F.\} and Henriques, \{Joaquim J.G.P.\} and Natalia Ignatenko and Debbie Koenig and Marta Lanza-Perea and Remo Lobetti and Lopezquintana, \{Adriana M.\} and Thibault Losfelt and Gabriele Marino and Inigo Martincorena and Casta{\~n}eda, \{Sim{\'o}n Mart{\'i}nez\} and Mart{\'i}nez-L{\'o}pez, \{Mayra F.\} and Michael Meyer and Berna Nakanwagi and \{De Nardi\}, \{Andrigo B.\} and Winifred Neunzig and Nixon, \{Sally J.\} and Onsare, \{Marsden M.\} and Antonio Ortega-Pacheco and Peleteiro, \{Maria C.\} and Pye, \{Ruth J.\} and Reece, \{John F.\} and Gutierrez, \{Jose Rojas\} and Haleema Sadia and Schmeling, \{Sheila K.\} and Olga Shamanova and Ssuna, \{Richard K.\} and Steenland-Smitsvitich, \{Audrey E.Alla\} and Ngoka, \{Ismail Thoya\} and Vitǎlaru, \{Bogdan A.\} and \{De Vos\}, \{Anna P.\} and \{De Vos\}, \{Johan P.\} and Oliver Walkinton and Wedge, \{David C.\} and Wehrle-Martinez, \{Alvaro S.\} and \{Van Der Wel\}, \{Mirjam G.\} and Widdowson, \{Sophie Ae\} and Murchison, \{Elizabeth P.\}",

note = "Publisher Copyright: {\textcopyright} Strakova et al.",

year = "2016",

month = may,

day = "17",

doi = "10.7554/eLife.14552",

language = "Ingl{\'e}s",

volume = "5",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications Ltd",

number = "MAY2016",

}

Strakova, A, Leathlobhair, MN, Wang, GD, Yin, TT, Airikkala-Otter, I, Allen, JL, Allum, KM, Bansse-Issa, L, Bisson, JL, Domracheva, AC, De Castro, KF, Corrigan, AM, Cran, HR, Crawford, JT, Cutter, SM, Keenan, LD, Donelan, EM, Faramade, IA, Reynoso, EF, Fotopoulou, E, Fruean, SN, Gallardo-Arrieta, F, Glebova, O, Häfelin Manrique, RF, Henriques, JJGP, Ignatenko, N, Koenig, D, Lanza-Perea, M, Lobetti, R, Lopezquintana, AM, Losfelt, T, Marino, G, Martincorena, I, Castañeda, SM, Martínez-López, MF, Meyer, M, Nakanwagi, B, De Nardi, AB, Neunzig, W, Nixon, SJ, Onsare, MM, Ortega-Pacheco, A, Peleteiro, MC, Pye, RJ, Reece, JF, Gutierrez, JR, Sadia, H, Schmeling, SK, Shamanova, O, Ssuna, RK, Steenland-Smitsvitich, AEA, Ngoka, IT, Vitǎlaru, BA, De Vos, AP, De Vos, JP, Walkinton, O, Wedge, DC, Wehrle-Martinez, AS, Van Der Wel, MG, Widdowson, SA & Murchison, EP 2016, 'Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer', eLife, vol. 5, n.º MAY2016, e14552. https://doi.org/10.7554/eLife.14552

TY - JOUR

T1 - Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

AU - Strakova, Andrea

AU - Leathlobhair, Máire Ní

AU - Wang, Guo Dong

AU - Yin, Ting Ting

AU - Airikkala-Otter, Ilona

AU - Allen, Janice L.

AU - Allum, Karen M.

AU - Bansse-Issa, Leontine

AU - Bisson, Jocelyn L.

AU - Domracheva, Artemio Castillo

AU - De Castro, Karina F.

AU - Corrigan, Anne M.

AU - Cran, Hugh R.

AU - Crawford, Jane T.

AU - Cutter, Stephen M.

AU - Keenan, Laura Delgadillo

AU - Donelan, Edward M.

AU - Faramade, Ibikunle A.

AU - Reynoso, Erika Flores

AU - Fotopoulou, Eleni

AU - Fruean, Skye N.

AU - Gallardo-Arrieta, Fanny

AU - Glebova, Olga

AU - Häfelin Manrique, Rodrigo F.

AU - Henriques, Joaquim J.G.P.

AU - Ignatenko, Natalia

AU - Koenig, Debbie

AU - Lanza-Perea, Marta

AU - Lobetti, Remo

AU - Lopezquintana, Adriana M.

AU - Losfelt, Thibault

AU - Marino, Gabriele

AU - Martincorena, Inigo

AU - Castañeda, Simón Martínez

AU - Martínez-López, Mayra F.

AU - Meyer, Michael

AU - Nakanwagi, Berna

AU - De Nardi, Andrigo B.

AU - Neunzig, Winifred

AU - Nixon, Sally J.

AU - Onsare, Marsden M.

AU - Ortega-Pacheco, Antonio

AU - Peleteiro, Maria C.

AU - Pye, Ruth J.

AU - Reece, John F.

AU - Gutierrez, Jose Rojas

AU - Sadia, Haleema

AU - Schmeling, Sheila K.

AU - Shamanova, Olga

AU - Ssuna, Richard K.

AU - Steenland-Smitsvitich, Audrey E.Alla

AU - Ngoka, Ismail Thoya

AU - Vitǎlaru, Bogdan A.

AU - De Vos, Anna P.

AU - De Vos, Johan P.

AU - Walkinton, Oliver

AU - Wedge, David C.

AU - Wehrle-Martinez, Alvaro S.

AU - Van Der Wel, Mirjam G.

AU - Widdowson, Sophie Ae

AU - Murchison, Elizabeth P.

PY - 2016/5/17

Y1 - 2016/5/17

N2 - Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.

AB - Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.

UR - https://www.scopus.com/pages/publications/84971672839

U2 - 10.7554/eLife.14552

DO - 10.7554/eLife.14552

M3 - Artículo

C2 - 27185408

AN - SCOPUS:84971672839

SN - 2050-084X

VL - 5

JO - eLife

JF - eLife

IS - MAY2016

M1 - e14552

ER -

Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

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