TY - JOUR
T1 - Medicinal and mechanistic overview of artemisinin in the treatment of human diseases
AU - Posadino, Anna Maria
AU - Giordo, Roberta
AU - Pintus, Gianfranco
AU - Mohammed, Soheb Anwar
AU - Orhan, Ilkay Erdogan
AU - Fokou, Patrick Valere Tsouh
AU - Sharopov, Farukh
AU - Adetunji, Charles Oluwaseun
AU - Gulsunoglu-Konuskan, Zehra
AU - Ydyrys, Alibek
AU - Armstrong, Lorene
AU - Sytar, Oksana
AU - Martorell, Miquel
AU - Razis, Ahmad Faizal Abdull
AU - Modu, Babagana
AU - Calina, Daniela
AU - Habtemariam, Solomon
AU - Sharifi-Rad, Javad
AU - Cho, William C.
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/7
Y1 - 2023/7
N2 - Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial infections, and some cardiovascular diseases, especially in Asia, North America, Europe and other parts of the world. This comprehensive review aims to update the biomedical potential of ART and its derivatives for treating human diseases highlighting its pharmacokinetic and pharmacological properties based on the results of experimental pharmacological studies in vitro and in vivo. Cellular and molecular mechanisms of action, tested doses and toxic effects of artemisinin were also described. The analysis of data based on an up-to-date literature search showed that ART and its derivatives display anticancer effects along with a wide range of pharmacological activities such as antibacterial, antiviral, antimalarial, antioxidant and cardioprotective effects. These compounds have great potential for discovering new drugs used as adjunctive therapies in cancer and various other diseases. Detailed translational and experimental studies are however needed to fully understand the pharmacological effects of these compounds.
AB - Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial infections, and some cardiovascular diseases, especially in Asia, North America, Europe and other parts of the world. This comprehensive review aims to update the biomedical potential of ART and its derivatives for treating human diseases highlighting its pharmacokinetic and pharmacological properties based on the results of experimental pharmacological studies in vitro and in vivo. Cellular and molecular mechanisms of action, tested doses and toxic effects of artemisinin were also described. The analysis of data based on an up-to-date literature search showed that ART and its derivatives display anticancer effects along with a wide range of pharmacological activities such as antibacterial, antiviral, antimalarial, antioxidant and cardioprotective effects. These compounds have great potential for discovering new drugs used as adjunctive therapies in cancer and various other diseases. Detailed translational and experimental studies are however needed to fully understand the pharmacological effects of these compounds.
KW - Anticancer
KW - Antimicrobial
KW - Antioxidant
KW - Artemisinin
KW - Pharmacological mechanisms
KW - Safety profile
UR - https://www.scopus.com/pages/publications/85159220191
U2 - 10.1016/j.biopha.2023.114866
DO - 10.1016/j.biopha.2023.114866
M3 - Artículo de revisión
C2 - 37182516
AN - SCOPUS:85159220191
SN - 0753-3322
VL - 163
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
M1 - 114866
ER -
