TY - JOUR
T1 - Mechanistic Insight of Pharmacological Aspects of Violacein
T2 - Recent Trends and Advancements
AU - Chauhan, Abhishek
AU - Mathkor, Darin Mansor
AU - Joshi, Hemant
AU - Chauhan, Ritu
AU - Sharma, Ujjawal
AU - Sharma, Vikas
AU - Kumar, Manoj
AU - Saini, Reena V.
AU - Saini, Adesh K.
AU - Tuli, Hardeep Singh
AU - Kaur, Damandeep
AU - Haque, Shafiul
N1 - Publisher Copyright:
© 2025 Wiley Periodicals LLC.
PY - 2025/2
Y1 - 2025/2
N2 - Since its discovery in the bacterium Chromobacterium violaceum, violacein—a striking purple pigment—has garnered significant interest due to its promising applications in the food and pharmaceutical industries. Violacein exhibits a range of pharmacological properties, including anti-inflammatory, anticancer, antibacterial, and antiparasitic effects, yet its complete molecular mechanisms are still being elucidated. Its mechanisms of action likely involve complex interactions with cellular receptors, signaling pathways, and specific molecular targets. Given violacein's unique properties and bioactive intermediates, future research holds substantial potential to advance its clinical and industrial applications. Upcoming studies will focus on deepening our understanding of violacein's molecular interactions, conducting clinical trials, and refining drug delivery systems to maximize its therapeutic value. Additionally, obtaining regulatory approval, conducting rigorous safety assessments, and developing efficient biosynthetic methods remain essential steps for violacein's successful integration into food biotechnology and medical applications.
AB - Since its discovery in the bacterium Chromobacterium violaceum, violacein—a striking purple pigment—has garnered significant interest due to its promising applications in the food and pharmaceutical industries. Violacein exhibits a range of pharmacological properties, including anti-inflammatory, anticancer, antibacterial, and antiparasitic effects, yet its complete molecular mechanisms are still being elucidated. Its mechanisms of action likely involve complex interactions with cellular receptors, signaling pathways, and specific molecular targets. Given violacein's unique properties and bioactive intermediates, future research holds substantial potential to advance its clinical and industrial applications. Upcoming studies will focus on deepening our understanding of violacein's molecular interactions, conducting clinical trials, and refining drug delivery systems to maximize its therapeutic value. Additionally, obtaining regulatory approval, conducting rigorous safety assessments, and developing efficient biosynthetic methods remain essential steps for violacein's successful integration into food biotechnology and medical applications.
KW - Chromobacterium violaceum
KW - biosynthesis pathways
KW - chemoprevention
KW - pharmacological mechanisms
KW - safety evaluation
UR - https://www.scopus.com/pages/publications/85216030197
U2 - 10.1002/jbt.70114
DO - 10.1002/jbt.70114
M3 - Artículo de revisión
C2 - 39865920
AN - SCOPUS:85216030197
SN - 1095-6670
VL - 39
JO - Journal of Biochemical and Molecular Toxicology
JF - Journal of Biochemical and Molecular Toxicology
IS - 2
M1 - e70114
ER -