TY - JOUR
T1 - Interleukin-6-174G > C (rs1800795) polymorphism distribution and its association with rheumatoid arthritis
T2 - A case-control study and meta-analysis
AU - Dar, Sajad Ahmad
AU - Haque, Shafiul
AU - Mandal, Raju Kumar
AU - Singh, Taru
AU - Wahid, Mohd
AU - Jawed, Arshad
AU - Panda, Aditya K.
AU - Akhter, Naseem
AU - Lohani, Mohtashim
AU - Areeshi, Mohammed Yahya
AU - Rai, Gargi
AU - Datt, Shyama
AU - Bhattacharya, Sambit Nath
AU - Ramachandran, Vishnampettai Ganapathysubramanian
AU - Das, Shukla
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/4/3
Y1 - 2017/4/3
N2 - The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients, attending a tertiary care hospital in north India. We also performed a meta-analysis, of the previously published studies reporting this genetic relationship, in overall population, and independently in Asian and Caucasian ethnicities to further elucidate this association. A total of 13 studies, including the current one, involving 3291 RA cases and 3812 controls were analyzed. Out of the 13 studies, 6 were from Asian, 6 from Caucasian and 1 from a mixed population. Our case-control study showed significant association of IL-6-174G > C SNP with increased RA risk: allelic (OR = 3.750, 95% CI = 1.800–7.813, p <0.001); dominant (OR = 2.800, 95% CI = 1.167–6.721, p =0.021); and recessive (OR = 36.72, 95% CI = 2.004–672.7, p =0.015). The meta-analysis revealed the increased RA risk associated with IL-6-174G > C SNP in overall population: allelic (OR = 1.650, 95% CI = 1.169–2.329, p =0.004); homozygous (OR = 1.380, 95% CI = 0.906–2.101, p = 0.133); heterozygous (OR = 1.559, 95% CI = 1.001–2.428, p =0.049); dominant (OR = 1.663, 95% CI = 1.078–2.567, p =0.022); and recessive (OR = 1.366, 95% CI = 0.964–1.935, p =0.079). Subgroup analysis also showed this polymorphism to be associated with increased RA risk in Asian population: allelic (OR = 3.724, 95% CI = 1.361–10.190, p =0.010); dominant (OR = 3.823, 95% CI = 1.320–11.074, p =0.013); and recessive (OR = 4.357, 95% CI = 1.634–11.623, p =0.003), but not in Caucasian population. This meta-analysis shows that IL-6-174G > C SNP is significantly associated with increased RA risk in overall, and specifically in Asian population.
AB - The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients, attending a tertiary care hospital in north India. We also performed a meta-analysis, of the previously published studies reporting this genetic relationship, in overall population, and independently in Asian and Caucasian ethnicities to further elucidate this association. A total of 13 studies, including the current one, involving 3291 RA cases and 3812 controls were analyzed. Out of the 13 studies, 6 were from Asian, 6 from Caucasian and 1 from a mixed population. Our case-control study showed significant association of IL-6-174G > C SNP with increased RA risk: allelic (OR = 3.750, 95% CI = 1.800–7.813, p <0.001); dominant (OR = 2.800, 95% CI = 1.167–6.721, p =0.021); and recessive (OR = 36.72, 95% CI = 2.004–672.7, p =0.015). The meta-analysis revealed the increased RA risk associated with IL-6-174G > C SNP in overall population: allelic (OR = 1.650, 95% CI = 1.169–2.329, p =0.004); homozygous (OR = 1.380, 95% CI = 0.906–2.101, p = 0.133); heterozygous (OR = 1.559, 95% CI = 1.001–2.428, p =0.049); dominant (OR = 1.663, 95% CI = 1.078–2.567, p =0.022); and recessive (OR = 1.366, 95% CI = 0.964–1.935, p =0.079). Subgroup analysis also showed this polymorphism to be associated with increased RA risk in Asian population: allelic (OR = 3.724, 95% CI = 1.361–10.190, p =0.010); dominant (OR = 3.823, 95% CI = 1.320–11.074, p =0.013); and recessive (OR = 4.357, 95% CI = 1.634–11.623, p =0.003), but not in Caucasian population. This meta-analysis shows that IL-6-174G > C SNP is significantly associated with increased RA risk in overall, and specifically in Asian population.
KW - Interleukin-6
KW - meta-analysis
KW - rheumatoid arthritis
KW - single nucleotide polymorphism
KW - susceptibility
UR - https://www.scopus.com/pages/publications/85007197667
U2 - 10.1080/08916934.2016.1261833
DO - 10.1080/08916934.2016.1261833
M3 - Artículo
C2 - 28010120
AN - SCOPUS:85007197667
SN - 0891-6934
VL - 50
SP - 158
EP - 169
JO - Autoimmunity
JF - Autoimmunity
IS - 3
ER -