Impact of p53 arg72pro snp on breast cancer risk in north indian population

Naseem Akhter; Sajad A. Dar; Shilpi Chattopadhyay; Shafiul Haque; Razique Anwer; Mohd Wahid; Arshad Jawed; Mohtashim Lohani; Raju K. Mandal; N. K. Shukla; Yasir Abdul; Syed Akhtar Husain

doi:10.2174/1389202919666171205104137

Impact of p53 arg72pro snp on breast cancer risk in north indian population

Naseem Akhter, Sajad A. Dar, Shilpi Chattopadhyay, Shafiul Haque, Razique Anwer, Mohd Wahid, Arshad Jawed, Mohtashim Lohani, Raju K. Mandal, N. K. Shukla, Yasir Abdul, Syed Akhtar Husain

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7 Citas (Scopus)

Resumen

Background: Genetic changes in p53 gene contribute to breast cancer susceptibility. Objective and Methods: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. Conclusion: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.

Idioma original	Inglés
Páginas (desde-hasta)	395-410
Número de páginas	16
Publicación	Current Genomics
Volumen	19
N.º	5
DOI	https://doi.org/10.2174/1389202919666171205104137
Estado	Publicada - 2018
Publicado de forma externa	Sí

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title = "Impact of p53 arg72pro snp on breast cancer risk in north indian population",

abstract = "Background: Genetic changes in p53 gene contribute to breast cancer susceptibility. Objective and Methods: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. Conclusion: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.",

keywords = "Breast cancer, Case-control, Indian populations, Meta-analysis, P53 Arg72Pro polymorphism, P53 codon72 SNP",

author = "Naseem Akhter and Dar, \{Sajad A.\} and Shilpi Chattopadhyay and Shafiul Haque and Razique Anwer and Mohd Wahid and Arshad Jawed and Mohtashim Lohani and Mandal, \{Raju K.\} and Shukla, \{N. K.\} and Yasir Abdul and Husain, \{Syed Akhtar\}",

note = "Publisher Copyright: {\textcopyright} 2018 Bentham Science Publishers.",

year = "2018",

doi = "10.2174/1389202919666171205104137",

language = "Ingl{\'e}s",

volume = "19",

pages = "395--410",

journal = "Current Genomics",

issn = "1389-2029",

publisher = "Bentham Science Publishers",

number = "5",

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TY - JOUR

T1 - Impact of p53 arg72pro snp on breast cancer risk in north indian population

AU - Akhter, Naseem

AU - Dar, Sajad A.

AU - Chattopadhyay, Shilpi

AU - Haque, Shafiul

AU - Anwer, Razique

AU - Wahid, Mohd

AU - Jawed, Arshad

AU - Lohani, Mohtashim

AU - Mandal, Raju K.

AU - Shukla, N. K.

AU - Abdul, Yasir

AU - Husain, Syed Akhtar

PY - 2018

Y1 - 2018

N2 - Background: Genetic changes in p53 gene contribute to breast cancer susceptibility. Objective and Methods: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. Conclusion: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.

AB - Background: Genetic changes in p53 gene contribute to breast cancer susceptibility. Objective and Methods: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. Conclusion: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.

KW - Breast cancer

KW - Case-control

KW - Indian populations

KW - Meta-analysis

KW - P53 Arg72Pro polymorphism

KW - P53 codon72 SNP

UR - https://www.scopus.com/pages/publications/85048960827

U2 - 10.2174/1389202919666171205104137

DO - 10.2174/1389202919666171205104137

M3 - Artículo

AN - SCOPUS:85048960827

SN - 1389-2029

VL - 19

SP - 395

EP - 410

JO - Current Genomics

JF - Current Genomics

IS - 5

ER -

Impact of p53 arg72pro snp on breast cancer risk in north indian population

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