TY - JOUR
T1 - Impact of LMP7 (rs2071543) gene polymorphism in increasing cancer risk
T2 - Evidence from a meta-analysis and trial sequential analysis
AU - Mandal, Raju K.
AU - Dar, Sajad A.
AU - Jawed, Arshad
AU - Wahid, Mohd
AU - Lohani, Mohtashim
AU - Panda, Aditya K.
AU - Mishra, Bhartendu N.
AU - Akhter, Naseem
AU - Areeshi, Mohammed Y.
AU - Haque, Shafiul
N1 - Publisher Copyright:
© Mandal et al.
PY - 2018
Y1 - 2018
N2 - Genetic variant LMP7 (low molecular weight polypeptide 7) -145 C > A may influence the function of immune surveillance of an individual and lead to cancer development. Various studies have investigated the relevance of LMP7 -145 C > A gene polymorphism with cancer risk; but, their results are conflicting and inconsistent. To obtain a comprehensive conclusion, a meta-analysis was performed by including eight eligible published studies retrieved from PubMed (Medline), EMBASE and Google Scholar web search until December 2016. Individuals with AA genotype (AA vs CC: p = 0.001; OR = 2.602, 95% CI = 1.780 to 3.803) of LMP7 -145 C > A were found to have 2 folds higher risk of cancer than those with CC genotype. The recessive genetic model (AA vs AC + CC) also indicated that individuals with AA genotype have 2 folds higher cancer risk than AC and CC genotypes (p = 0.001; OR = 2.216, 95% CI = 1.525 to 3.221). Also, significant increased cancer risk was observed in Asians but not in Caucasians. No publication bias was observed during the analysis. Trial sequential analysis also strengthened our current findings. These results suggest that genetic variant LMP7-145 C > A has significant role in increasing cancer risk in overall and Asian population, and could be useful as a prognostic marker for early cancer predisposition.
AB - Genetic variant LMP7 (low molecular weight polypeptide 7) -145 C > A may influence the function of immune surveillance of an individual and lead to cancer development. Various studies have investigated the relevance of LMP7 -145 C > A gene polymorphism with cancer risk; but, their results are conflicting and inconsistent. To obtain a comprehensive conclusion, a meta-analysis was performed by including eight eligible published studies retrieved from PubMed (Medline), EMBASE and Google Scholar web search until December 2016. Individuals with AA genotype (AA vs CC: p = 0.001; OR = 2.602, 95% CI = 1.780 to 3.803) of LMP7 -145 C > A were found to have 2 folds higher risk of cancer than those with CC genotype. The recessive genetic model (AA vs AC + CC) also indicated that individuals with AA genotype have 2 folds higher cancer risk than AC and CC genotypes (p = 0.001; OR = 2.216, 95% CI = 1.525 to 3.221). Also, significant increased cancer risk was observed in Asians but not in Caucasians. No publication bias was observed during the analysis. Trial sequential analysis also strengthened our current findings. These results suggest that genetic variant LMP7-145 C > A has significant role in increasing cancer risk in overall and Asian population, and could be useful as a prognostic marker for early cancer predisposition.
KW - Cancer susceptibility
KW - LMP7
KW - Meta-analysis
KW - Polymorphism
KW - Trial sequential analysis
UR - https://www.scopus.com/pages/publications/85040647312
U2 - 10.18632/oncotarget.23547
DO - 10.18632/oncotarget.23547
M3 - Artículo
C2 - 29464093
AN - SCOPUS:85040647312
SN - 1949-2553
VL - 9
SP - 6572
EP - 6585
JO - Oncotarget
JF - Oncotarget
IS - 5
ER -
