TY - JOUR
T1 - Genomic epidemiology of SARS-CoV-2 transmission lineages in Ecuador
AU - Gutierrez, Bernardo
AU - Márquez, Sully
AU - Prado-Vivar, Belén
AU - Becerra-Wong, Mónica
AU - Guadalupe, Juan José
AU - da Silva Candido, Darlan
AU - Fernandez-Cadena, Juan Carlos
AU - Morey-Leon, Gabriel
AU - Armas-Gonzalez, Rubén
AU - Andrade-Molina, Derly Madeleiny
AU - Bruno, Alfredo
AU - de Mora, Domenica
AU - Olmedo, Maritza
AU - Portugal, Denisse
AU - Gonzalez, Manuel
AU - Orlando, Alberto
AU - Drexler, Jan Felix
AU - Moreira-Soto, Andres
AU - Sander, Anna Lena
AU - Brünink, Sebastian
AU - Kühne, Arne
AU - Patiño, Leandro
AU - Carrazco-Montalvo, Andrés
AU - Mestanza, Orson
AU - Zurita, Jeannete
AU - Sevillano, Gabriela
AU - du Plessis, Louis
AU - McCrone, John T.
AU - Coloma, Josefina
AU - Trueba, Gabriel
AU - Barragán, Verónica
AU - Rojas-Silva, Patricio
AU - Grunauer, Michelle
AU - Kraemer, Moritz U.G.
AU - Faria, Nuno R.
AU - Escalera-Zamudio, Marina
AU - Pybus, Oliver G.
AU - Cárdenas, Paúl
N1 - Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press.
PY - 2021
Y1 - 2021
N2 - Characterisation of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic diversity through space and time can reveal trends in virus importation and domestic circulation and permit the exploration of questions regarding the early transmission dynamics. Here, we present a detailed description of SARS-CoV-2 genomic epidemiology in Ecuador, one of the hardest hit countries during the early stages of the coronavirus-19 pandemic. We generated and analysed 160 whole genome sequences sampled from all provinces of Ecuador in 2020. Molecular clock and phylogeographic analysis of these sequences in the context of global SARS-CoV-2 diversity enable us to identify and characterise individual transmission lineages within Ecuador, explore their spatiotemporal distributions, and consider their introduction and domestic circulation. Our results reveal a pattern of multiple international importations across the country, with apparent differences between key provinces. Transmission lineages were mostly introduced before the implementation of non-pharmaceutical interventions, with differential degrees of persistence and national dissemination.
AB - Characterisation of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic diversity through space and time can reveal trends in virus importation and domestic circulation and permit the exploration of questions regarding the early transmission dynamics. Here, we present a detailed description of SARS-CoV-2 genomic epidemiology in Ecuador, one of the hardest hit countries during the early stages of the coronavirus-19 pandemic. We generated and analysed 160 whole genome sequences sampled from all provinces of Ecuador in 2020. Molecular clock and phylogeographic analysis of these sequences in the context of global SARS-CoV-2 diversity enable us to identify and characterise individual transmission lineages within Ecuador, explore their spatiotemporal distributions, and consider their introduction and domestic circulation. Our results reveal a pattern of multiple international importations across the country, with apparent differences between key provinces. Transmission lineages were mostly introduced before the implementation of non-pharmaceutical interventions, with differential degrees of persistence and national dissemination.
KW - Molecular epidemiology
KW - Phylogenetics
KW - Phylogeography
KW - SARS-CoV-2
KW - Transmission lineages
UR - https://www.scopus.com/pages/publications/85116591433
U2 - 10.1093/ve/veab051
DO - 10.1093/ve/veab051
M3 - Artículo
AN - SCOPUS:85116591433
SN - 2057-1577
VL - 7
JO - Virus Evolution
JF - Virus Evolution
IS - 2
M1 - A1343
ER -