TY - JOUR
T1 - Flavonoids as potential anti-platelet aggregation agents
T2 - from biochemistry to health promoting abilities
AU - Sharifi-Rad, Javad
AU - Quispe, Cristina
AU - Shaheen, Shabnum
AU - El Haouari, Mohammed
AU - Azzini, Elena
AU - Butnariu, Monica
AU - Sarac, Ioan
AU - Pentea, Marius
AU - Ramírez-Alarcón, Karina
AU - Martorell, Miquel
AU - Kumar, Manoj
AU - Docea, Anca Oana
AU - Cruz-Martins, Natália
AU - Calina, Daniela
N1 - Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - Cardiovascular ailments are the number one cause of mortalities throughout the globe with 17.9 million deaths per year. Platelet activation and aggregation play a crucial role in the pathogenesis of arterial diseases, including acute coronary syndrome, acute myocardial infarction, cerebrovascular transient ischemia, unstable angina, among others. Flavonoids-rich plant extracts are gaining interest for treating the heart-related problems due to safe nature of these herbal extracts. Consumption of plant-food-derived bioactives, particularly flavonoids, has shown antithrombotic, and cardiovascular protective effects due to its anti-platelet activity. Preclinical and clinical trials have proven that flavonoid-rich plant extracts are protective against the cardiac ailments through anti-platelet aggregation activity. This review aims to highlight the anti-platelet aggregation potential of flavonoids with a key emphasis on the therapeutic efficacy in humans. The mechanism of flavonoids in preventing and treating cardiovascular diseases is also highlighted based on preclinical and clinical experimental trials. Further studies are the need of time for exploring the exact molecular mechanism of flavonoids as anti-platelet aggregation agents for treating heart-related problems.
AB - Cardiovascular ailments are the number one cause of mortalities throughout the globe with 17.9 million deaths per year. Platelet activation and aggregation play a crucial role in the pathogenesis of arterial diseases, including acute coronary syndrome, acute myocardial infarction, cerebrovascular transient ischemia, unstable angina, among others. Flavonoids-rich plant extracts are gaining interest for treating the heart-related problems due to safe nature of these herbal extracts. Consumption of plant-food-derived bioactives, particularly flavonoids, has shown antithrombotic, and cardiovascular protective effects due to its anti-platelet activity. Preclinical and clinical trials have proven that flavonoid-rich plant extracts are protective against the cardiac ailments through anti-platelet aggregation activity. This review aims to highlight the anti-platelet aggregation potential of flavonoids with a key emphasis on the therapeutic efficacy in humans. The mechanism of flavonoids in preventing and treating cardiovascular diseases is also highlighted based on preclinical and clinical experimental trials. Further studies are the need of time for exploring the exact molecular mechanism of flavonoids as anti-platelet aggregation agents for treating heart-related problems.
KW - Flavonoids
KW - anti-platelet aggregation
KW - mechanisms of action
KW - preclinical studies
KW - signaling pathways
UR - https://www.scopus.com/pages/publications/85106048008
U2 - 10.1080/10408398.2021.1924612
DO - 10.1080/10408398.2021.1924612
M3 - Artículo de revisión
C2 - 33983094
AN - SCOPUS:85106048008
SN - 1040-8398
VL - 62
SP - 8045
EP - 8058
JO - Critical Reviews in Food Science and Nutrition
JF - Critical Reviews in Food Science and Nutrition
IS - 29
ER -
