TY - JOUR
T1 - Ferulic Acid
T2 - A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
AU - Singh Tuli, Hardeep
AU - Kumar, Ajay
AU - Ramniwas, Seema
AU - Coudhary, Renuka
AU - Aggarwal, Diwakar
AU - Kumar, Manoj
AU - Sharma, Ujjawal
AU - Chaturvedi Parashar, Nidarshana
AU - Haque, Shafiul
AU - Sak, Katrin
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/11
Y1 - 2022/11
N2 - Despite the immense therapeutic advances in the field of health sciences, cancer is still to be found among the global leading causes of morbidity and mortality. Ethnomedicinally, natural bioactive compounds isolated from various plant sources have been used for the treatment of several cancer types and have gained notable attention. Ferulic acid, a natural compound derived from various seeds, nuts, leaves, and fruits, exhibits a variety of pharmacological effects in cancer, including its proapoptotic, cell-cycle-arresting, anti-metastatic, and anti-inflammatory activities. This review study presents a thorough overview of the molecular targets and cellular signaling pathways modulated by ferulic acid in diverse malignancies, showing high potential for this phenolic acid to be developed as a candidate agent for novel anticancer therapeutics. In addition, current investigations to develop promising synergistic formulations are also discussed.
AB - Despite the immense therapeutic advances in the field of health sciences, cancer is still to be found among the global leading causes of morbidity and mortality. Ethnomedicinally, natural bioactive compounds isolated from various plant sources have been used for the treatment of several cancer types and have gained notable attention. Ferulic acid, a natural compound derived from various seeds, nuts, leaves, and fruits, exhibits a variety of pharmacological effects in cancer, including its proapoptotic, cell-cycle-arresting, anti-metastatic, and anti-inflammatory activities. This review study presents a thorough overview of the molecular targets and cellular signaling pathways modulated by ferulic acid in diverse malignancies, showing high potential for this phenolic acid to be developed as a candidate agent for novel anticancer therapeutics. In addition, current investigations to develop promising synergistic formulations are also discussed.
KW - anti-angiogenesis
KW - anti-metastasis
KW - apoptosis and cell cycle arrest
KW - ferulic acid
KW - synergism
UR - https://www.scopus.com/pages/publications/85141577200
U2 - 10.3390/molecules27217653
DO - 10.3390/molecules27217653
M3 - Artículo de revisión
C2 - 36364478
AN - SCOPUS:85141577200
SN - 1420-3049
VL - 27
JO - Molecules
JF - Molecules
IS - 21
M1 - 7653
ER -
