TY - JOUR
T1 - Ellagic Acid
T2 - A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential
AU - Sharifi-Rad, Javad
AU - Quispe, Cristina
AU - Castillo, Carla Marina Salgado
AU - Caroca, Rodrigo
AU - Lazo-Vélez, Marco A.
AU - Antonyak, Halyna
AU - Polishchuk, Alexandr
AU - Lysiuk, Roman
AU - Oliinyk, Petro
AU - De Masi, Luigi
AU - Bontempo, Paola
AU - Martorell, Miquel
AU - Daştan, Sevgi Durna
AU - Rigano, Daniela
AU - Wink, Michael
AU - Cho, William C.
N1 - Publisher Copyright:
© 2022 Javad Sharifi-Rad et al.
PY - 2022
Y1 - 2022
N2 - Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate (Punica granatum L.) and in wood and bark of some tree species. Structurally, EA is a dilactone of hexahydroxydiphenic acid (HHDP), a dimeric gallic acid derivative, produced mainly by hydrolysis of ellagitannins, a widely distributed group of secondary metabolites. EA is attracting attention due to its antioxidant, anti-inflammatory, antimutagenic, and antiproliferative properties. EA displayed pharmacological effects in various in vitro and in vivo model systems. Furthermore, EA has also been well documented for its antiallergic, antiatherosclerotic, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties. This review reports on the health-promoting effects of EA, along with possible mechanisms of its action in maintaining the health status, by summarizing the literature related to the therapeutic potential of this polyphenolic in the treatment of several human diseases.
AB - Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate (Punica granatum L.) and in wood and bark of some tree species. Structurally, EA is a dilactone of hexahydroxydiphenic acid (HHDP), a dimeric gallic acid derivative, produced mainly by hydrolysis of ellagitannins, a widely distributed group of secondary metabolites. EA is attracting attention due to its antioxidant, anti-inflammatory, antimutagenic, and antiproliferative properties. EA displayed pharmacological effects in various in vitro and in vivo model systems. Furthermore, EA has also been well documented for its antiallergic, antiatherosclerotic, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties. This review reports on the health-promoting effects of EA, along with possible mechanisms of its action in maintaining the health status, by summarizing the literature related to the therapeutic potential of this polyphenolic in the treatment of several human diseases.
UR - https://www.scopus.com/pages/publications/85125610938
U2 - 10.1155/2022/3848084
DO - 10.1155/2022/3848084
M3 - Artículo
C2 - 35237379
AN - SCOPUS:85125610938
SN - 1942-0900
VL - 2022
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
M1 - 3848084
ER -
