TY - JOUR
T1 - Diet, lifestyle and cardiovascular diseases
T2 - Linking pathophysiology to cardioprotective effects of natural bioactive compounds
AU - Sharifi-Rad, Javad
AU - Rodrigues, Célia F.
AU - Sharopov, Farukh
AU - Docea, Anca Oana
AU - Karaca, Asli Can
AU - Sharifi-Rad, Mehdi
AU - Karincaoglu, Derya Kahveci
AU - Gülseren, Gözde
AU - Şenol, Ezgi
AU - Demircan, Evren
AU - Taheri, Yasaman
AU - Suleria, Hafiz Ansar Rasul
AU - Özçelik, Beraat
AU - Kasapoğlu, Kadriye Nur
AU - Gültekin-Özgüven, Mine
AU - Daşkaya-Dikmen, Ceren
AU - Cho, William C.
AU - Martins, Natália
AU - Calina, Daniela
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.
AB - Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.
KW - Arterial hypertension
KW - Atherosclerosis
KW - Cardio-protective pharmacotherapy
KW - Classical and emerging risk factors
KW - Coronary artery disease
KW - Diabetes
KW - Diet
KW - Food
KW - Lifestyle
KW - Plant-food bioactive compounds
UR - https://www.scopus.com/pages/publications/85082792264
U2 - 10.3390/ijerph17072326
DO - 10.3390/ijerph17072326
M3 - Artículo de revisión
C2 - 32235611
AN - SCOPUS:85082792264
SN - 1661-7827
VL - 17
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 7
M1 - 2326
ER -
