TY - JOUR
T1 - Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol
AU - Coêlho, Mayara Ladeira
AU - Islam, Muhammad Torequl
AU - Laylson Da Silva Oliveira, George
AU - Oliveira Barros De Alencar, Marcus Vinicius
AU - Victor De Oliveira Santos, José
AU - Campinho Dos Reis, Antonielly
AU - Oliveira Ferreira Da Mata, Ana Maria
AU - Correia Jardim Paz, Márcia Fernanda
AU - Docea, Anca Oana
AU - Calina, Daniela
AU - Sharifi-Rad, Javad
AU - Amélia De Carvalho Melo-Cavalcante, Ana
N1 - Publisher Copyright:
© 2022 Mayara Ladeira Coêlho et al.
PY - 2022
Y1 - 2022
N2 - The therapeutic potential of medicinal plants is noted because of the presence of varieties of biochemicals. The monoterpenes, like nerol, estragole, and 3,7-dimethyl-1-octanol, have been reported for antimicrobial, antifungal, anthelmintic, and antioxidant activities. This study evaluated the toxic, cytotoxic, and oxidant/antioxidant effects of these compounds by several in vitro (DPPH and ABTS radical scavenging, and ferric reducing potential), ex vivo (hemolysis), and in vivo (Artemia Salina and Saccharomyces cerevisiae) assays. Results suggest that estragole and 3,7-dimethyl-1-octanol at 31.25-500 μg/mL did not exhibit significant cytotoxic effects in the A. Salina and hemolysis tests. Nerol showed significant cytotoxic effects on these test systems at all test concentrations. The monoterpenes showed radical (ABTS•+ and DPPH•) scavenging capacities in a concentration-dependent manner in vitro tests. However, they did not oxidize the genetic material of S. cerevisiae (SODWT, Sod1Δ, Sod2Δ, Sod1/Sod2Δ, Cat1Δ, and Cat1Δ/Sod1Δ) lines. Among the three monoterpenes, nerol may be a good candidate for antioxidant and anti-tumor therapies.
AB - The therapeutic potential of medicinal plants is noted because of the presence of varieties of biochemicals. The monoterpenes, like nerol, estragole, and 3,7-dimethyl-1-octanol, have been reported for antimicrobial, antifungal, anthelmintic, and antioxidant activities. This study evaluated the toxic, cytotoxic, and oxidant/antioxidant effects of these compounds by several in vitro (DPPH and ABTS radical scavenging, and ferric reducing potential), ex vivo (hemolysis), and in vivo (Artemia Salina and Saccharomyces cerevisiae) assays. Results suggest that estragole and 3,7-dimethyl-1-octanol at 31.25-500 μg/mL did not exhibit significant cytotoxic effects in the A. Salina and hemolysis tests. Nerol showed significant cytotoxic effects on these test systems at all test concentrations. The monoterpenes showed radical (ABTS•+ and DPPH•) scavenging capacities in a concentration-dependent manner in vitro tests. However, they did not oxidize the genetic material of S. cerevisiae (SODWT, Sod1Δ, Sod2Δ, Sod1/Sod2Δ, Cat1Δ, and Cat1Δ/Sod1Δ) lines. Among the three monoterpenes, nerol may be a good candidate for antioxidant and anti-tumor therapies.
UR - https://www.scopus.com/pages/publications/85143874428
U2 - 10.1155/2022/8002766
DO - 10.1155/2022/8002766
M3 - Artículo
AN - SCOPUS:85143874428
SN - 2633-4682
VL - 2022
JO - Advances in Pharmacological and Pharmaceutical Sciences
JF - Advances in Pharmacological and Pharmaceutical Sciences
M1 - 8002766
ER -