Curcumin’s nanomedicine formulations for therapeutic application in neurological diseases

Bahare Salehi; Daniela Calina; Anca Oana Docea; Niranjan Koirala; Sushant Aryal; Domenico Lombardo; Luigi Pasqua; Yasaman Taheri; Carla Marina Salgado Castillo; Miquel Martorell; Natália Martins; Marcello Iriti; Hafiz Ansar Rasul Suleria; Javad Sharifi‐rad

doi:10.3390/jcm9020430

Curcumin’s nanomedicine formulations for therapeutic application in neurological diseases

Bahare Salehi, Daniela Calina, Anca Oana Docea, Niranjan Koirala, Sushant Aryal, Domenico Lombardo, Luigi Pasqua, Yasaman Taheri, Carla Marina Salgado Castillo, Miquel Martorell, Natália Martins, Marcello Iriti, Hafiz Ansar Rasul Suleria, Javad Sharifi‐rad

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

162 Citas (Scopus)

Resumen

The brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β‐binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.

Idioma original	Inglés
Número de artículo	430
Publicación	Journal of Clinical Medicine
Volumen	9
N.º	2
DOI	https://doi.org/10.3390/jcm9020430
Estado	Publicada - feb. 2020
Publicado de forma externa	Sí

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Salehi, B., Calina, D., Docea, A. O., Koirala, N., Aryal, S., Lombardo, D., Pasqua, L., Taheri, Y., Castillo, C. M. S., Martorell, M., Martins, N., Iriti, M., Suleria, H. A. R., & Sharifi‐rad, J. (2020). Curcumin’s nanomedicine formulations for therapeutic application in neurological diseases. Journal of Clinical Medicine, 9(2), Artículo 430. https://doi.org/10.3390/jcm9020430

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abstract = "The brain is the body{\textquoteright}s control center, so when a disease affects it, the outcomes are devastating. Alzheimer{\textquoteright}s and Parkinson{\textquoteright}s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β‐binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.",

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month = feb,

doi = "10.3390/jcm9020430",

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AU - Salehi, Bahare

AU - Calina, Daniela

AU - Docea, Anca Oana

AU - Koirala, Niranjan

AU - Aryal, Sushant

AU - Lombardo, Domenico

AU - Pasqua, Luigi

AU - Taheri, Yasaman

AU - Castillo, Carla Marina Salgado

AU - Martorell, Miquel

AU - Martins, Natália

AU - Iriti, Marcello

AU - Suleria, Hafiz Ansar Rasul

AU - Sharifi‐rad, Javad

PY - 2020/2

Y1 - 2020/2

N2 - The brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β‐binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.

AB - The brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β‐binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.

KW - Curcumin

KW - Liposomes

KW - Nanocarriers

KW - Nanocurcumin

KW - Neurological disorders

UR - https://www.scopus.com/pages/publications/85081649200

U2 - 10.3390/jcm9020430

DO - 10.3390/jcm9020430

M3 - Artículo de revisión

AN - SCOPUS:85081649200

SN - 2077-0383

VL - 9

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 2

M1 - 430

ER -

Curcumin’s nanomedicine formulations for therapeutic application in neurological diseases

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