Citrinin as a potential anti-cancer therapy: A comprehensive review

Ag Anne P.M. de Menezes; Raí P.S. Aguiar; José V.O. Santos; Chandan Sarkar; Muhammad T. Islam; Antonio L. Braga; Mohammad M. Hasan; Felipe C.C. da Silva; Javad Sharifi-Rad; Abhijit Dey; Daniela Calina; Ana A.C. Melo-Cavalcante; João M.C. Sousa

doi:10.1016/j.cbi.2023.110561

Citrinin as a potential anti-cancer therapy: A comprehensive review

Ag Anne P.M. de Menezes
, Raí P.S. Aguiar
, José V.O. Santos
, Chandan Sarkar
, Muhammad T. Islam
, Antonio L. Braga
, Mohammad M. Hasan
, Felipe C.C. da Silva
, Javad Sharifi-Rad
, Abhijit Dey
, Daniela Calina
, Ana A.C. Melo-Cavalcante
, João M.C. Sousa

Universidade Federal do Piauí
Bangabandhu Sheikh Mujibur Rahman Science and Technology University
Mawlana Bhashani Science and Technology University
Universidad del Azuay
Presidency College India
Craiova University of Medicine and Pharmacy

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

23 Citas (Scopus)

Resumen

Citrinin (CIT) is a polyketide-derived mycotoxin, which is produced by many fungal strains belonging to the gerena Monascus, Aspergillus, and Penicillium. It has been postulated that mycotoxins have several toxic mechanisms and are potentially used as antineoplastic agents. Therefore, the present study carried out a systematic review, including articles from 1978 to 2022, by collecting evidence in experimental studies of CIT antiplorifactive activity in cancer. The Data indicate that CIT intervenes in important mediators and cell signaling pathways, including MAPKs, ERK1/2, JNK, Bcl-2, BAX, caspases 3,6,7 and 9, p53, p21, PARP cleavage, MDA, reactive oxygen species (ROS) and antioxidant defenses (SOD, CAT, GST and GPX). These factors demonstrate the potential antitumor drug CIT in inducing cell death, reducing DNA repair capacity and inducing cytotoxic and genotoxic effects in cancer cells.

Idioma original	Inglés
Número de artículo	110561
Publicación	Chemico-Biological Interactions
Volumen	381
DOI	https://doi.org/10.1016/j.cbi.2023.110561
Estado	Publicada - 25 ago. 2023
Publicado de forma externa	Sí

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de Menezes, A. A. P. M., Aguiar, R. P. S., Santos, J. V. O., Sarkar, C., Islam, M. T., Braga, A. L., Hasan, M. M., da Silva, F. C. C., Sharifi-Rad, J., Dey, A., Calina, D., Melo-Cavalcante, A. A. C., & Sousa, J. M. C. (2023). Citrinin as a potential anti-cancer therapy: A comprehensive review. Chemico-Biological Interactions, 381, Artículo 110561. https://doi.org/10.1016/j.cbi.2023.110561

@article{4af639d08258480eb9add1dc944f2c01,

title = "Citrinin as a potential anti-cancer therapy: A comprehensive review",

abstract = "Citrinin (CIT) is a polyketide-derived mycotoxin, which is produced by many fungal strains belonging to the gerena Monascus, Aspergillus, and Penicillium. It has been postulated that mycotoxins have several toxic mechanisms and are potentially used as antineoplastic agents. Therefore, the present study carried out a systematic review, including articles from 1978 to 2022, by collecting evidence in experimental studies of CIT antiplorifactive activity in cancer. The Data indicate that CIT intervenes in important mediators and cell signaling pathways, including MAPKs, ERK1/2, JNK, Bcl-2, BAX, caspases 3,6,7 and 9, p53, p21, PARP cleavage, MDA, reactive oxygen species (ROS) and antioxidant defenses (SOD, CAT, GST and GPX). These factors demonstrate the potential antitumor drug CIT in inducing cell death, reducing DNA repair capacity and inducing cytotoxic and genotoxic effects in cancer cells.",

keywords = "Antiplorifactive mechanisms, Cytotoxicity, Genotoxicity, Mycotoxins, Toxicity",

author = "\{de Menezes\}, \{Ag Anne P.M.\} and Aguiar, \{Ra{\'i} P.S.\} and Santos, \{Jos{\'e} V.O.\} and Chandan Sarkar and Islam, \{Muhammad T.\} and Braga, \{Antonio L.\} and Hasan, \{Mohammad M.\} and \{da Silva\}, \{Felipe C.C.\} and Javad Sharifi-Rad and Abhijit Dey and Daniela Calina and Melo-Cavalcante, \{Ana A.C.\} and Sousa, \{Jo{\~a}o M.C.\}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

month = aug,

day = "25",

doi = "10.1016/j.cbi.2023.110561",

language = "Ingl{\'e}s",

volume = "381",

journal = "Chemico-Biological Interactions",

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TY - JOUR

T1 - Citrinin as a potential anti-cancer therapy

T2 - A comprehensive review

AU - de Menezes, Ag Anne P.M.

AU - Aguiar, Raí P.S.

AU - Santos, José V.O.

AU - Sarkar, Chandan

AU - Islam, Muhammad T.

AU - Braga, Antonio L.

AU - Hasan, Mohammad M.

AU - da Silva, Felipe C.C.

AU - Sharifi-Rad, Javad

AU - Dey, Abhijit

AU - Calina, Daniela

AU - Melo-Cavalcante, Ana A.C.

AU - Sousa, João M.C.

PY - 2023/8/25

Y1 - 2023/8/25

N2 - Citrinin (CIT) is a polyketide-derived mycotoxin, which is produced by many fungal strains belonging to the gerena Monascus, Aspergillus, and Penicillium. It has been postulated that mycotoxins have several toxic mechanisms and are potentially used as antineoplastic agents. Therefore, the present study carried out a systematic review, including articles from 1978 to 2022, by collecting evidence in experimental studies of CIT antiplorifactive activity in cancer. The Data indicate that CIT intervenes in important mediators and cell signaling pathways, including MAPKs, ERK1/2, JNK, Bcl-2, BAX, caspases 3,6,7 and 9, p53, p21, PARP cleavage, MDA, reactive oxygen species (ROS) and antioxidant defenses (SOD, CAT, GST and GPX). These factors demonstrate the potential antitumor drug CIT in inducing cell death, reducing DNA repair capacity and inducing cytotoxic and genotoxic effects in cancer cells.

AB - Citrinin (CIT) is a polyketide-derived mycotoxin, which is produced by many fungal strains belonging to the gerena Monascus, Aspergillus, and Penicillium. It has been postulated that mycotoxins have several toxic mechanisms and are potentially used as antineoplastic agents. Therefore, the present study carried out a systematic review, including articles from 1978 to 2022, by collecting evidence in experimental studies of CIT antiplorifactive activity in cancer. The Data indicate that CIT intervenes in important mediators and cell signaling pathways, including MAPKs, ERK1/2, JNK, Bcl-2, BAX, caspases 3,6,7 and 9, p53, p21, PARP cleavage, MDA, reactive oxygen species (ROS) and antioxidant defenses (SOD, CAT, GST and GPX). These factors demonstrate the potential antitumor drug CIT in inducing cell death, reducing DNA repair capacity and inducing cytotoxic and genotoxic effects in cancer cells.

KW - Antiplorifactive mechanisms

KW - Cytotoxicity

KW - Genotoxicity

KW - Mycotoxins

KW - Toxicity

UR - https://www.scopus.com/pages/publications/85163265195

U2 - 10.1016/j.cbi.2023.110561

DO - 10.1016/j.cbi.2023.110561

M3 - Artículo de revisión

C2 - 37230156

AN - SCOPUS:85163265195

SN - 0009-2797

VL - 381

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

M1 - 110561

ER -

Citrinin as a potential anti-cancer therapy: A comprehensive review

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