TY - JOUR
T1 - Citrinin as a potential anti-cancer therapy
T2 - A comprehensive review
AU - de Menezes, Ag Anne P.M.
AU - Aguiar, Raí P.S.
AU - Santos, José V.O.
AU - Sarkar, Chandan
AU - Islam, Muhammad T.
AU - Braga, Antonio L.
AU - Hasan, Mohammad M.
AU - da Silva, Felipe C.C.
AU - Sharifi-Rad, Javad
AU - Dey, Abhijit
AU - Calina, Daniela
AU - Melo-Cavalcante, Ana A.C.
AU - Sousa, João M.C.
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/8/25
Y1 - 2023/8/25
N2 - Citrinin (CIT) is a polyketide-derived mycotoxin, which is produced by many fungal strains belonging to the gerena Monascus, Aspergillus, and Penicillium. It has been postulated that mycotoxins have several toxic mechanisms and are potentially used as antineoplastic agents. Therefore, the present study carried out a systematic review, including articles from 1978 to 2022, by collecting evidence in experimental studies of CIT antiplorifactive activity in cancer. The Data indicate that CIT intervenes in important mediators and cell signaling pathways, including MAPKs, ERK1/2, JNK, Bcl-2, BAX, caspases 3,6,7 and 9, p53, p21, PARP cleavage, MDA, reactive oxygen species (ROS) and antioxidant defenses (SOD, CAT, GST and GPX). These factors demonstrate the potential antitumor drug CIT in inducing cell death, reducing DNA repair capacity and inducing cytotoxic and genotoxic effects in cancer cells.
AB - Citrinin (CIT) is a polyketide-derived mycotoxin, which is produced by many fungal strains belonging to the gerena Monascus, Aspergillus, and Penicillium. It has been postulated that mycotoxins have several toxic mechanisms and are potentially used as antineoplastic agents. Therefore, the present study carried out a systematic review, including articles from 1978 to 2022, by collecting evidence in experimental studies of CIT antiplorifactive activity in cancer. The Data indicate that CIT intervenes in important mediators and cell signaling pathways, including MAPKs, ERK1/2, JNK, Bcl-2, BAX, caspases 3,6,7 and 9, p53, p21, PARP cleavage, MDA, reactive oxygen species (ROS) and antioxidant defenses (SOD, CAT, GST and GPX). These factors demonstrate the potential antitumor drug CIT in inducing cell death, reducing DNA repair capacity and inducing cytotoxic and genotoxic effects in cancer cells.
KW - Antiplorifactive mechanisms
KW - Cytotoxicity
KW - Genotoxicity
KW - Mycotoxins
KW - Toxicity
UR - https://www.scopus.com/pages/publications/85163265195
U2 - 10.1016/j.cbi.2023.110561
DO - 10.1016/j.cbi.2023.110561
M3 - Artículo de revisión
C2 - 37230156
AN - SCOPUS:85163265195
SN - 0009-2797
VL - 381
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
M1 - 110561
ER -
