TY - JOUR
T1 - Cinnamomum Species
T2 - Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits
AU - Sharifi-Rad, Javad
AU - Dey, Abhijit
AU - Koirala, Niranjan
AU - Shaheen, Shabnum
AU - El Omari, Nasreddine
AU - Salehi, Bahare
AU - Goloshvili, Tamar
AU - Cirone Silva, Nathália Cristina
AU - Bouyahya, Abdelhakim
AU - Vitalini, Sara
AU - Varoni, Elena M.
AU - Martorell, Miquel
AU - Abdolshahi, Anna
AU - Docea, Anca Oana
AU - Iriti, Marcello
AU - Calina, Daniela
AU - Les, Francisco
AU - López, Víctor
AU - Caruntu, Constantin
N1 - Publisher Copyright:
© Copyright © 2021 Sharifi-Rad, Dey, Koirala, Shaheen, El Omari, Salehi, Goloshvili, Cirone Silva, Bouyahya, Vitalini, Varoni, Martorell, Abdolshahi, Docea, Iriti, Calina, Les, López and Caruntu.
PY - 2021/5/11
Y1 - 2021/5/11
N2 - The genus Cinnamomum includes a number of plant species largely used as food, food additives and spices for a long time. Different traditional healing systems have used these plants as herbal remedies to cure diverse ailments. The aim of this comprehensive and updated review is to summarize the biodiversity of the genus Cinnamomum, its bioactive compounds, the mechanisms that underlie the pharmacological activities and molecular targets and toxicological safety. All the data in this review have been collected from databases and recent scientific literature including Web of Science, PubMed, ScienceDirect etc. The results showed that the bioactive compounds of Cinnamomum species possess antimicrobial, antidiabetic, antioxidant, anti-inflammatory, anticancer and neuroprotective effects. The preclinical (in vitro/in vivo) studies provided the possible molecular mechanisms of these action. As a novelty, recent clinical studies and toxicological data described in this paper support and confirm the pharmacological importance of the genus Cinnamomum. In conclusion, the obtained results from preclinical studies and clinical trials, as well as reduced side effects provide insights into future research of new drugs based on extracts and bioactive compounds from Cinnamomum plants.
AB - The genus Cinnamomum includes a number of plant species largely used as food, food additives and spices for a long time. Different traditional healing systems have used these plants as herbal remedies to cure diverse ailments. The aim of this comprehensive and updated review is to summarize the biodiversity of the genus Cinnamomum, its bioactive compounds, the mechanisms that underlie the pharmacological activities and molecular targets and toxicological safety. All the data in this review have been collected from databases and recent scientific literature including Web of Science, PubMed, ScienceDirect etc. The results showed that the bioactive compounds of Cinnamomum species possess antimicrobial, antidiabetic, antioxidant, anti-inflammatory, anticancer and neuroprotective effects. The preclinical (in vitro/in vivo) studies provided the possible molecular mechanisms of these action. As a novelty, recent clinical studies and toxicological data described in this paper support and confirm the pharmacological importance of the genus Cinnamomum. In conclusion, the obtained results from preclinical studies and clinical trials, as well as reduced side effects provide insights into future research of new drugs based on extracts and bioactive compounds from Cinnamomum plants.
KW - Ciannamomum spp
KW - Pharmacology
KW - Toxicological data
KW - clinical trials
KW - mechanisms of action
KW - phytochemistry
UR - https://www.scopus.com/pages/publications/85107072707
U2 - 10.3389/fphar.2021.600139
DO - 10.3389/fphar.2021.600139
M3 - Artículo de revisión
AN - SCOPUS:85107072707
SN - 1663-9812
VL - 12
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 600139
ER -