TY - JOUR
T1 - Chemical composition and functional properties of essential oils from Nepeta schiraziana Boiss
AU - Sharifi-Rad, Javad
AU - Ayatollahi, Seyed Abdulmajid
AU - Varoni, Elena M.
AU - Salehi, Bahare
AU - Kobarfard, Farzad
AU - Sharifi-Rad, Mehdi
AU - Iriti, Marcello
AU - Sharifi-Rad, Marzieh
N1 - Publisher Copyright:
© 2017, Romanian Society for Pharmaceutical Sciences. All rights reserved.
PY - 2017
Y1 - 2017
N2 - Nepeta schiraziana Boiss. (Lamiaceae) is a species endemic of Iran used in traditional medicine to treat a number of ailments. This study investigates the chemical composition as well as the cytotoxic, antimicrobial, acetylcholinesterase (AChE) inhibitory and antioxidant activities of N. schiraziana essential oil (EO). EO chemical composition was analysed by GC-MS. Cytotoxicity was evaluated against MCF-7 and Hep-G2 cancer cells, while antimicrobial activity was assessed against fungi (Candida albicans, Aspergillus niger), Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gramnegative (Klebsiella pneumonia, Pseudomonas aeruginosa) bacteria. Forty-four compounds were identified; the main constituents were 1,8-cineole (33.67%), germacrene D (11.45%), β-caryophyllene (9.88%), caryophyllene oxide (7.34%). N. schiraziana EO showed a concentration-dependent cytotoxicity against both cancer cell lines. It also significantly inhibited the growth of A. niger (MIC 1.85 ± 1.12) and C. albicans (MIC 4.94 ± 3.07 μg/mL). MIC for S. aureus, B. subtilis, K. pneumoniae and P. aeruginosa were 16.37 ± 1.23, 168.22 ± 2.14, 180.99 ± 4.67 and 248.74 ± 5.12 μg/mL, respectively. Slight antiradical and AChE inhibitory activities were measured. This is the first report on the chemical composition and bioactivities of N. schiraziana EO. The antibacterial, antifungal and anticancer properties were confirmed in vitro.
AB - Nepeta schiraziana Boiss. (Lamiaceae) is a species endemic of Iran used in traditional medicine to treat a number of ailments. This study investigates the chemical composition as well as the cytotoxic, antimicrobial, acetylcholinesterase (AChE) inhibitory and antioxidant activities of N. schiraziana essential oil (EO). EO chemical composition was analysed by GC-MS. Cytotoxicity was evaluated against MCF-7 and Hep-G2 cancer cells, while antimicrobial activity was assessed against fungi (Candida albicans, Aspergillus niger), Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gramnegative (Klebsiella pneumonia, Pseudomonas aeruginosa) bacteria. Forty-four compounds were identified; the main constituents were 1,8-cineole (33.67%), germacrene D (11.45%), β-caryophyllene (9.88%), caryophyllene oxide (7.34%). N. schiraziana EO showed a concentration-dependent cytotoxicity against both cancer cell lines. It also significantly inhibited the growth of A. niger (MIC 1.85 ± 1.12) and C. albicans (MIC 4.94 ± 3.07 μg/mL). MIC for S. aureus, B. subtilis, K. pneumoniae and P. aeruginosa were 16.37 ± 1.23, 168.22 ± 2.14, 180.99 ± 4.67 and 248.74 ± 5.12 μg/mL, respectively. Slight antiradical and AChE inhibitory activities were measured. This is the first report on the chemical composition and bioactivities of N. schiraziana EO. The antibacterial, antifungal and anticancer properties were confirmed in vitro.
KW - Acetylcholinesterase inhibitory activity
KW - Anticancer activity
KW - Antimicrobial activity
KW - Antioxidant activity
KW - Iranian endemism
KW - Lamiaceae
UR - https://www.scopus.com/pages/publications/85032361224
M3 - Artículo
AN - SCOPUS:85032361224
SN - 0014-8237
VL - 65
SP - 802
EP - 812
JO - Farmacia
JF - Farmacia
IS - 5
ER -
