TY - JOUR
T1 - Bioactivities of morroniside
T2 - A comprehensive review of pharmacological properties and molecular mechanisms
AU - Bhuia, Md Shimul
AU - Chowdhury, Raihan
AU - Ara, Iffat
AU - Mamun, Md
AU - Rouf, Razina
AU - Khan, Muahmmad Ali
AU - Uddin, Shaikh Jamal
AU - Shakil, Md Abdul Kader
AU - Habtemariam, Solomon
AU - Ferdous, Jannatul
AU - Calina, Daniela
AU - Sharifi-Rad, Javad
AU - Islam, Muhammad Torequl
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/6
Y1 - 2024/6
N2 - Morroniside (MOR) is an iridoid glycoside and the main active principle of the medicinal plant, Cornus officinalis Sieb. This phytochemical is associated with numerous health benefits due to its antioxidant properties. The primary objective of the present study was to assess the pharmacological effects and underlying mechanisms of MOR, utilizing published data obtained from literature databases. Data collection involved accessing various sources, including PubMed/Medline, Scopus, Science Direct, Google Scholar, Web of Science, and SpringerLink. Our findings demonstrate that MOR can be utilized for the treatment of several diseases and disorders, as numerous studies have revealed its significant therapeutic activities. These activities encompass anti-inflammatory, antidiabetic, lipid-lowering capability, anticancer, trichogenic, hepatoprotective, gastroprotective, osteoprotective, renoprotective, and cardioprotective effects. MOR has also shown promising benefits against various neurological ailments, including Alzheimer's disease, Parkinson's disease, spinal cord injury, cerebral ischemia, and neuropathic pain. Considering these therapeutic features, MOR holds promise as a lead compound for the treatment of various ailments and disorders. However, further comprehensive preclinical and clinical trials are required to establish MOR as an effective and reliable therapeutic agent.
AB - Morroniside (MOR) is an iridoid glycoside and the main active principle of the medicinal plant, Cornus officinalis Sieb. This phytochemical is associated with numerous health benefits due to its antioxidant properties. The primary objective of the present study was to assess the pharmacological effects and underlying mechanisms of MOR, utilizing published data obtained from literature databases. Data collection involved accessing various sources, including PubMed/Medline, Scopus, Science Direct, Google Scholar, Web of Science, and SpringerLink. Our findings demonstrate that MOR can be utilized for the treatment of several diseases and disorders, as numerous studies have revealed its significant therapeutic activities. These activities encompass anti-inflammatory, antidiabetic, lipid-lowering capability, anticancer, trichogenic, hepatoprotective, gastroprotective, osteoprotective, renoprotective, and cardioprotective effects. MOR has also shown promising benefits against various neurological ailments, including Alzheimer's disease, Parkinson's disease, spinal cord injury, cerebral ischemia, and neuropathic pain. Considering these therapeutic features, MOR holds promise as a lead compound for the treatment of various ailments and disorders. However, further comprehensive preclinical and clinical trials are required to establish MOR as an effective and reliable therapeutic agent.
KW - Iridoid glycoside
KW - Molecular mechanisms of action
KW - Morronisde
KW - Pharmacological activities
UR - https://www.scopus.com/pages/publications/85188018414
U2 - 10.1016/j.fitote.2024.105896
DO - 10.1016/j.fitote.2024.105896
M3 - Artículo de revisión
C2 - 38471574
AN - SCOPUS:85188018414
SN - 0367-326X
VL - 175
JO - Fitoterapia
JF - Fitoterapia
M1 - 105896
ER -