TY - JOUR
T1 - Bioactive Effects of Curcumin in Human Immunodeficiency Virus Infection Along with the Most Effective Isolation Techniques and Type of Nanoformulations
AU - Butnariu, Monica
AU - Quispe, Cristina
AU - Koirala, Niranjan
AU - Khadka, Sujan
AU - Salgado-Castillo, Carla Marina
AU - Akram, Muhammad
AU - Anum, Rabia
AU - Yeskaliyeva, Balakyz
AU - Cruz-Martins, Natália
AU - Kumar, Miquel Martorell Manoj
AU - Bagiu, Radu Vasile
AU - Razis, Ahmad Faizal Abdull
AU - Sunusi, Usman
AU - Kamal, Ramla Muhammad
AU - Sharifi-Rad, Javad
N1 - Publisher Copyright:
© 2022 Butnariu et al.
PY - 2022
Y1 - 2022
N2 - Human immunodeficiency virus (HIV) is one of the leading causes of death worldwide, with African countries being the worst affected by this deadly virus. Curcumin (CUR) is a Curcuma longa-derived polyphenol that has attracted the attention of researchers due to its antimicrobial, anti-inflammatory, antioxidant, immunomodulatory and antiviral effects. CUR also demonstrates anti-HIV effects by acting as a possible inhibitor of gp120 binding, integrase, protease, and topoisomerase II activities, besides also exerting a protective action against HIV-associated diseases. However, its effectiveness is limited due to its poor water solubility, rapid metabolism, and systemic elimination. Nanoformulations have been shown to be useful to enhance curcumin’s bioavailability and its effectiveness as an anti-HIV agent. In this sense, bioactive effects of CUR in HIV infection are carefully reviewed, along with the most effective isolation techniques and type of nanoformulations available.
AB - Human immunodeficiency virus (HIV) is one of the leading causes of death worldwide, with African countries being the worst affected by this deadly virus. Curcumin (CUR) is a Curcuma longa-derived polyphenol that has attracted the attention of researchers due to its antimicrobial, anti-inflammatory, antioxidant, immunomodulatory and antiviral effects. CUR also demonstrates anti-HIV effects by acting as a possible inhibitor of gp120 binding, integrase, protease, and topoisomerase II activities, besides also exerting a protective action against HIV-associated diseases. However, its effectiveness is limited due to its poor water solubility, rapid metabolism, and systemic elimination. Nanoformulations have been shown to be useful to enhance curcumin’s bioavailability and its effectiveness as an anti-HIV agent. In this sense, bioactive effects of CUR in HIV infection are carefully reviewed, along with the most effective isolation techniques and type of nanoformulations available.
KW - HIV therapy
KW - bioactivities
KW - curcumin
KW - nanoformulations
KW - nanoparticles
UR - https://www.scopus.com/pages/publications/85135866663
U2 - 10.2147/IJN.S364501
DO - 10.2147/IJN.S364501
M3 - Artículo de revisión
C2 - 35996526
AN - SCOPUS:85135866663
SN - 1176-9114
VL - 17
SP - 3619
EP - 3632
JO - International Journal of Nanomedicine
JF - International Journal of Nanomedicine
ER -
