TY - JOUR
T1 - Association between enteric dysmotility and GnRH antibodies
T2 - A meta-analysis
AU - Motawea, Karam R.
AU - Hassan, Noheir Ashraf Ibrahem Fathy
AU - Talat, Nesreen Elsayed
AU - Elhalag, Rowan H.
AU - Swed, Sarya
AU - Nashwan, Abdulqadir J.
AU - Bakkour, Agyad
AU - Sawaf, Bisher
AU - Cherrez-Ojeda, Ivan
AU - Hafez, Wael
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/10
Y1 - 2023/10
N2 - Background and aim: Recent studies reported a significant association between enteric dysmotility and GnRH antibodies, other studies reported no significant association. Therefore, we aimed to perform a meta-analysis to investigate and clarify the exact association between enteric dysmotility and GnRH antibodies. Methods: PubMed, Web of Science, and Scopus databases were searched. The inclusion criteria were any randomized control trials or observational studies that reported the level or prevalence of GnRH IgM or GnRH IgG antibodies in patients with enteric dysmotility matched with healthy controls. Exclusion criteria: Case reports, case series, reviews, editorials, and animal studies. RevMan software 5.4 was used to perform the meta-analysis. Results: After search of the literature, 4 studies were included in the meta-analysis with a total number of 469 individuals included in the study. The pooled analysis showed a statistically significant association between enteric dysmotility and increased prevalence of GnRH IgM antibodies compared with controls (RR = 4.47, 95% CI = 1.17 to 17.06, p-value = 0.03). Contrarily, no statistically significant association between enteric dysmotility and the levels of IgM antibodies as well as the prevalence of IgG antibodies was found compared with controls, (MD = 0.92, 95% CI = -1.01 to 2.86, p-value = 0.35) and (RR = 1.84, 95% CI = 0.09 to 35.86, p-value = 0.69), respectively. Conclusion: Our study detected a significant association between intestinal dysmotility and high prevalence of GnRH IgM antibodies when matched with controls. Conversely, we found no statistically significant association between enteric dysmotility and IgG antibodies. Further research is warranted to support our results and clarify the exact association between enteric dysmotility and GnRH antibodies.
AB - Background and aim: Recent studies reported a significant association between enteric dysmotility and GnRH antibodies, other studies reported no significant association. Therefore, we aimed to perform a meta-analysis to investigate and clarify the exact association between enteric dysmotility and GnRH antibodies. Methods: PubMed, Web of Science, and Scopus databases were searched. The inclusion criteria were any randomized control trials or observational studies that reported the level or prevalence of GnRH IgM or GnRH IgG antibodies in patients with enteric dysmotility matched with healthy controls. Exclusion criteria: Case reports, case series, reviews, editorials, and animal studies. RevMan software 5.4 was used to perform the meta-analysis. Results: After search of the literature, 4 studies were included in the meta-analysis with a total number of 469 individuals included in the study. The pooled analysis showed a statistically significant association between enteric dysmotility and increased prevalence of GnRH IgM antibodies compared with controls (RR = 4.47, 95% CI = 1.17 to 17.06, p-value = 0.03). Contrarily, no statistically significant association between enteric dysmotility and the levels of IgM antibodies as well as the prevalence of IgG antibodies was found compared with controls, (MD = 0.92, 95% CI = -1.01 to 2.86, p-value = 0.35) and (RR = 1.84, 95% CI = 0.09 to 35.86, p-value = 0.69), respectively. Conclusion: Our study detected a significant association between intestinal dysmotility and high prevalence of GnRH IgM antibodies when matched with controls. Conversely, we found no statistically significant association between enteric dysmotility and IgG antibodies. Further research is warranted to support our results and clarify the exact association between enteric dysmotility and GnRH antibodies.
KW - Enteric dysmotility
KW - GnRH antibodies
KW - Meta-analysis
UR - https://www.scopus.com/pages/publications/85186916837
U2 - 10.1016/j.gande.2023.08.002
DO - 10.1016/j.gande.2023.08.002
M3 - Artículo de revisión
AN - SCOPUS:85186916837
SN - 2949-7523
VL - 1
SP - 159
EP - 164
JO - Gastroenterology and Endoscopy
JF - Gastroenterology and Endoscopy
IS - 4
ER -