TY - JOUR
T1 - Apoptotic and antimetastatic effect of cucurbitacins in cancer
T2 - recent trends and advancement
AU - Kumar, Ajay
AU - Sharma, Bunty
AU - Sharma, Ujjawal
AU - Parashar, Gaurav
AU - Parashar, Nidarshana Chaturvedi
AU - Rani, Isha
AU - Ramniwas, Seema
AU - Kaur, Satwinderjeet
AU - Haque, Shafiul
AU - Tuli, Hardeep Singh
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2023/9
Y1 - 2023/9
N2 - The Cucurbitaceae family produces a class of secondary metabolites known as cucurbitacins. The eight cucurbitacin subunits are cucurbitacin B, D, E, I, IIa, L glucoside, Q, and R with the most significant anticancer activity. They are reported to inhibit cell proliferation, invasion, and migration; induce apoptosis; and encourage cell cycle arrest, as some of their modes of action. The JAK-STAT3, Wnt, PI3K/Akt, and MAPK signaling pathways, which are essential for the survival and apoptosis of cancer cells, have also been shown to be suppressed by cucurbitacins. The goal of the current study is to summarize potential molecular targets that cucurbitacins could inhibit in order to suppress various malignant processes. The review is noteworthy since it presents all putative molecular targets for cucurbitacins in cancer on a single podium.
AB - The Cucurbitaceae family produces a class of secondary metabolites known as cucurbitacins. The eight cucurbitacin subunits are cucurbitacin B, D, E, I, IIa, L glucoside, Q, and R with the most significant anticancer activity. They are reported to inhibit cell proliferation, invasion, and migration; induce apoptosis; and encourage cell cycle arrest, as some of their modes of action. The JAK-STAT3, Wnt, PI3K/Akt, and MAPK signaling pathways, which are essential for the survival and apoptosis of cancer cells, have also been shown to be suppressed by cucurbitacins. The goal of the current study is to summarize potential molecular targets that cucurbitacins could inhibit in order to suppress various malignant processes. The review is noteworthy since it presents all putative molecular targets for cucurbitacins in cancer on a single podium.
KW - Antimetastatic
KW - Apoptosis
KW - Cell cycle arrest
KW - Cucurbitacins
KW - Invasion
UR - https://www.scopus.com/pages/publications/85151447887
U2 - 10.1007/s00210-023-02471-z
DO - 10.1007/s00210-023-02471-z
M3 - Artículo de revisión
C2 - 37010571
AN - SCOPUS:85151447887
SN - 0028-1298
VL - 396
SP - 1867
EP - 1878
JO - Naunyn-Schmiedeberg's Archives of Pharmacology
JF - Naunyn-Schmiedeberg's Archives of Pharmacology
IS - 9
ER -
