TY - JOUR
T1 - Anticancer properties of sulforaphane
T2 - current insights at the molecular level
AU - Asif Ali, Muhammad
AU - Khan, Noohela
AU - Kaleem, Nabeeha
AU - Ahmad, Waqas
AU - Alharethi, Salem Hussain
AU - Alharbi, Bandar
AU - Alhassan, Hassan H.
AU - Al-Enazi, Maher M.
AU - Razis, Ahmad Faizal Abdull
AU - Modu, Babagana
AU - Calina, Daniela
AU - Sharifi-Rad, Javad
N1 - Publisher Copyright:
Copyright © 2023 Asif Ali, Khan, Kaleem, Ahmad, Alharethi, Alharbi, Alhassan, Al-Enazi, Razis, Modu, Calina and Sharifi-Rad.
PY - 2023
Y1 - 2023
N2 - Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.
AB - Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.
KW - anticancer mechanisms
KW - apoptosis
KW - cytotoxicity
KW - isothiocyanate
KW - sulforaphane
UR - https://www.scopus.com/pages/publications/85164411933
U2 - 10.3389/fonc.2023.1168321
DO - 10.3389/fonc.2023.1168321
M3 - Artículo de revisión
AN - SCOPUS:85164411933
SN - 2234-943X
VL - 13
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 1168321
ER -
