TY - JOUR
T1 - Anticancer properties of bromelain
T2 - State-of-the-art and recent trends
AU - Pezzani, Raffaele
AU - Jiménez-Garcia, Manuel
AU - Capó, Xavier
AU - Sönmez Gürer, Eda
AU - Sharopov, Farukh
AU - Rachel, Tchokouaha Yamthe Lauve
AU - Ntieche Woutouoba, David
AU - Rescigno, Antonio
AU - Peddio, Stefania
AU - Zucca, Paolo
AU - Tsouh Fokou, Patrick Valere
AU - Martorell, Miquel
AU - Gulsunoglu-Konuskan, Zehra
AU - Ydyrys, Alibek
AU - Bekzat, Tynybekov
AU - Gulmira, Tussupbekova
AU - Hano, Christophe
AU - Sharifi-Rad, Javad
AU - Calina, Daniela
N1 - Publisher Copyright:
Copyright © 2023 Pezzani, Jiménez-Garcia, Capó, Sönmez Gürer, Sharopov, Rachel, Ntieche Woutouoba, Rescigno, Peddio, Zucca, Tsouh Fokou, Martorell, Gulsunoglu-Konuskan, Ydyrys, Bekzat, Gulmira, Hano, Sharifi-Rad and Calina.
PY - 2023/1/9
Y1 - 2023/1/9
N2 - Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic substance with multiple beneficial effects for human health such as anti-inflammatory, immunomodulatory, antioxidant and anticarcinogenic, traditionally used in many countries for its potential therapeutic value. The aim of this updated and comprehensive review focuses on the potential anticancer benefits of bromelain, analyzing the cytotoxic, apoptotic, necrotic, autophagic, immunomodulating, and anti-inflammatory effects in cancer cells and animal models. Detailed information about Bromelain and its anticancer effects at the cellular, molecular and signaling levels were collected from online databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar. The results of the analyzed studies showed that Bromelain possesses corroborated pharmacological activities, such as anticancer, anti-edema, anti-inflammatory, anti-microbial, anti-coagulant, anti-osteoarthritis, anti-trauma pain, anti-diarrhea, wound repair. Nonetheless, bromelain clinical studies are scarce and still more research is needed to validate the scientific value of this enzyme in human cancer diseases.
AB - Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic substance with multiple beneficial effects for human health such as anti-inflammatory, immunomodulatory, antioxidant and anticarcinogenic, traditionally used in many countries for its potential therapeutic value. The aim of this updated and comprehensive review focuses on the potential anticancer benefits of bromelain, analyzing the cytotoxic, apoptotic, necrotic, autophagic, immunomodulating, and anti-inflammatory effects in cancer cells and animal models. Detailed information about Bromelain and its anticancer effects at the cellular, molecular and signaling levels were collected from online databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar. The results of the analyzed studies showed that Bromelain possesses corroborated pharmacological activities, such as anticancer, anti-edema, anti-inflammatory, anti-microbial, anti-coagulant, anti-osteoarthritis, anti-trauma pain, anti-diarrhea, wound repair. Nonetheless, bromelain clinical studies are scarce and still more research is needed to validate the scientific value of this enzyme in human cancer diseases.
KW - apoptosis
KW - bromelain
KW - cancer
KW - chemotherapeutics
KW - cytotoxicity
KW - molecular targets
UR - https://www.scopus.com/pages/publications/85146901665
U2 - 10.3389/fonc.2022.1068778
DO - 10.3389/fonc.2022.1068778
M3 - Artículo de revisión
AN - SCOPUS:85146901665
SN - 2234-943X
VL - 12
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 1068778
ER -
