Anti-Schistosoma mansoni effects of essential oils and their components

Schistosoma mansoni is endemic in 55 countries around the world. S. mansoni is a water-borne parasite of humans belonging to the group of blood flukes. Generally, schistosomiasis is treated with praziquantel, which results in frequent treatment failures and reinfections. Essential oils have diverse biological effects, including antimicrobial, antiprotozoal and antiparasitic. This review aimed at summarizing available in vitro, in vivo and clinical trials showing evidence and mechanisms of actions of essential oils and their derivatives acting against S. mansoni. The findings suggest that a number of essential oils and/or their components act against S. mansoni. Essential oils and/or their derivatives may be one of the potential sources of antischistosomal drugs.