TY - JOUR
T1 - A reappraised meta-analysis of the genetic association between Vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk
AU - Areeshi, Mohammed Y.
AU - Mandal, Raju K.
AU - Dar, Sajad A.
AU - Alshahrani, Abdulrahman M.
AU - Ahmad, Aqeel
AU - Jawed, Arshad
AU - Wahid, Mohd
AU - Lohani, Mohtashim
AU - Panda, Aditya K.
AU - Haque, Shafiul
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/6/30
Y1 - 2017/6/30
N2 - BsmI (rs1544410) polymorphism located in intron 8 at the 3'-end of the Vitamin D receptor (VDR) gene is known to be involved in the regulation of mRNA stability. Many studies evaluated the possible correlation between VDR BsmI polymorphism and the risk of pulmonary tuberculosis (PTB), and reported conflicting results. In the present study, an updated meta-analysis was performed to evaluate the above-said association. PubMed, Embase, and Google Scholar web-databases were searched for the relevant studies and a meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models. A total of 19 studies comprising 3644 controls and 2635 cases were included in the present study. Overall no association of PTB in allelic contrast (b compared with B: P=0.285; OR =0.909, 95% CI =0.762-1.083), homozygous (bb compared with BB: P=0.881; OR =0.975, 95% CI =0.700-1.359), heterozygous (bB compared with BB: P=0.834; OR =1.017, 95% CI =0.872-1.185), dominant (bb compared with BB + Bb: P=0.451; OR =0.954, 95% CI =0.843-1.079) and recessive (bb + Bb compared with BB: P=0.983; OR =1.002, 95% CI =0.868-1.156) genetic models in comparison with wild-type allele and genotype BB were observed. However, variant allele (b compared with B: P=0.001; OR =2.289, 95% CI =1.661-3.154) showed increased risk of PTB in Asians. In conclusion, VDR BsmI polymorphism is not a risk factor for PTB in overall population. However, this polymorphism may be interrelated to an increased risk of PTB amongst Asians.
AB - BsmI (rs1544410) polymorphism located in intron 8 at the 3'-end of the Vitamin D receptor (VDR) gene is known to be involved in the regulation of mRNA stability. Many studies evaluated the possible correlation between VDR BsmI polymorphism and the risk of pulmonary tuberculosis (PTB), and reported conflicting results. In the present study, an updated meta-analysis was performed to evaluate the above-said association. PubMed, Embase, and Google Scholar web-databases were searched for the relevant studies and a meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models. A total of 19 studies comprising 3644 controls and 2635 cases were included in the present study. Overall no association of PTB in allelic contrast (b compared with B: P=0.285; OR =0.909, 95% CI =0.762-1.083), homozygous (bb compared with BB: P=0.881; OR =0.975, 95% CI =0.700-1.359), heterozygous (bB compared with BB: P=0.834; OR =1.017, 95% CI =0.872-1.185), dominant (bb compared with BB + Bb: P=0.451; OR =0.954, 95% CI =0.843-1.079) and recessive (bb + Bb compared with BB: P=0.983; OR =1.002, 95% CI =0.868-1.156) genetic models in comparison with wild-type allele and genotype BB were observed. However, variant allele (b compared with B: P=0.001; OR =2.289, 95% CI =1.661-3.154) showed increased risk of PTB in Asians. In conclusion, VDR BsmI polymorphism is not a risk factor for PTB in overall population. However, this polymorphism may be interrelated to an increased risk of PTB amongst Asians.
UR - https://www.scopus.com/pages/publications/85021431797
U2 - 10.1042/BSR20170247
DO - 10.1042/BSR20170247
M3 - Artículo
C2 - 28533426
AN - SCOPUS:85021431797
SN - 0144-8463
VL - 37
JO - Bioscience Reports
JF - Bioscience Reports
IS - 3
M1 - BSR20170247
ER -
