TY - JOUR
T1 - A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy
AU - Sharifi-Rad, Javad
AU - Quispe, Cristina
AU - Herrera-Bravo, Jesús
AU - Martorell, Miquel
AU - Sharopov, Farukh
AU - Tumer, Tugba Boyunegmez
AU - Kurt, Begum
AU - Lankatillake, Chintha
AU - Docea, Anca Oana
AU - Moreira, Ana Catarina
AU - Dias, Daniel A.
AU - Mahomoodally, Mohamad Fawzi
AU - Lobine, Devina
AU - Cruz-Martins, Natália
AU - Kumar, Manoj
AU - Calina, Daniela
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/9
Y1 - 2021/9
N2 - Epilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are widely used. The purpose of this systematic review was to analyze the antiepileptic/anticonvulsant pharmacological properties of plant-food derived bioactive molecules. In this regard, a systematic review of the PubMed database was made based on the inclusion criteria. Natural compounds/herbs with scientifically proven antiepileptic properties were selected. Experimental pharmacological studies in vitro and in vivo have shown that flavonoids, alkaloids and terpenoids may have anticonvulsant mechanisms similar to the new generation antiepileptic drugs. The relationships of structure-anticonvulsant effect, pharmacological models, seizure-inducing factors and response, effective dose were also analyzed and discussed. The results of in vitro and in vivo pharmacological studies analyzed in this systematic review support the clinical importance of plant-food-derived bioactive molecules for the complementary treatment of epilepsy. Thus, are opened new perspectives to develop new natural anticonvulsant drugs.
AB - Epilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are widely used. The purpose of this systematic review was to analyze the antiepileptic/anticonvulsant pharmacological properties of plant-food derived bioactive molecules. In this regard, a systematic review of the PubMed database was made based on the inclusion criteria. Natural compounds/herbs with scientifically proven antiepileptic properties were selected. Experimental pharmacological studies in vitro and in vivo have shown that flavonoids, alkaloids and terpenoids may have anticonvulsant mechanisms similar to the new generation antiepileptic drugs. The relationships of structure-anticonvulsant effect, pharmacological models, seizure-inducing factors and response, effective dose were also analyzed and discussed. The results of in vitro and in vivo pharmacological studies analyzed in this systematic review support the clinical importance of plant-food-derived bioactive molecules for the complementary treatment of epilepsy. Thus, are opened new perspectives to develop new natural anticonvulsant drugs.
KW - Anticonvulsant
KW - Epilepsy
KW - Herbal medicines
KW - Molecular mechanisms
KW - Natural compounds
KW - Pharmacological models
UR - https://www.scopus.com/pages/publications/85107849326
U2 - 10.1007/s11064-021-03376-0
DO - 10.1007/s11064-021-03376-0
M3 - Artículo de revisión
C2 - 34120291
AN - SCOPUS:85107849326
SN - 0364-3190
VL - 46
SP - 2205
EP - 2225
JO - Neurochemical Research
JF - Neurochemical Research
IS - 9
ER -