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Unveiling the potential of HS-1793: a review of its anticancer properties and therapeutic promise

  • Xavier Capó
  • , Manuel Jiménez-Garcia
  • , Farukh Sharopov
  • , Patrick Valere Tsouh Fokou
  • , Miquel Martorell
  • , Afaf Ahmed Aldahish
  • , Raffaele Pezzani
  • , Javad Sharifi-Rad
  • , Daniela Calina
  • Fundació Institut d'Investigació Sanitària Illes Balears
  • University of the Balearic Islands
  • Academy of Sciences of the Republic of Tadzhikistan
  • University of Bamenda
  • Universidad de Concepción
  • King Khalid University
  • University of Padua
  • Accademia Italiana di Fitoterapia
  • Centro de Estudios Tecnológicos y Universitarios del Golfo
  • Korea University
  • Craiova University of Medicine and Pharmacy

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

HS-1793 is a novel derivative of resveratrol, a compound known for its numerous beneficial effects, including anticancer activity, anti-inflammatory response, antimicrobial, antiaging, anti-cardiovascular disease activity, neuroprotective activity, etc. Despite its wide and interesting properties, resveratrol suffers from a crucial flaw because it is low bioavailable. For this reason, many other derivatives were explored and among them, HS-1793 has caught the attention of researchers. HS-1793 is a synthetic derivative of resveratrol discovered in 2007 that has been shown to have anti-cancer and anti-inflammatory properties. In addition, the compound showed a positive profile in metabolic processes, with adequate pharmacokinetics and pharmacodynamics. This review highlights current research on HS-1793, evaluating in vitro and in vivo works and lays the foundation for novel explorative trials in human diseases.

Original languageEnglish
Pages (from-to)2301-2311
Number of pages11
JournalFuture Medicinal Chemistry
Volume16
Issue number21
DOIs
StatePublished - 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • HS-1793
  • anticancer
  • bioavailability
  • cell models
  • preclinical
  • resveratrol

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