The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria

T. Zuberbier; Z. Abdul Hameed Ansari; A. H. Abdul Latiff; M. M. Abuzakouk; M. S. Agcaoili-De Jesus; R. C. Agondi; M. Al-Ahmad; A. A. Alangari; H. Alhameli; C. D. Alonso Bello; S. Alshareef; S. Al-Tamemi; S. Altrichter; H. Al Wahshi; S. Aquilina; M. Araújo; R. Arnaout; R. Asero; B. Ballmer-Weber; C. Bangert; A. Bauer; M. Ben-Shoshan; J. Bernstein; C. Bindslev-Jensen; M. Bizjak; I. Boccon-Gibod; H. Bonnekoh; L. Bouillet; K. Brockow; Z. Brzoza; M. Bulatović Ćalasan; A. Bulkhi; T. Buttgereit; A. Bygum; T. Caballero; O. Calderon; R. Campos; M. Cancian; E. Carne; M. A. Castor; I. Cerecedo; T. Çetinarslan; I. Cherrez-Ojeda; N. Chkhikvadze; H. J. Chong-Neto; K. Choo; G. Christoff; C. Y. Chu; K. Ciupka; N. Conlon; C. Costa; T. Craig; P. Criado; I. Danilycheva; R. Darlenski; E. De Arruda Chaves; L. de Montjoye; M. S. Doutre; A. Du-Thanh; D. Ebo; S. Elkhalifa; S. Elmariah; T. El-Shanawany; L. F. Ensina; R. Ertaş; R. Fachini Jardim Criado; M. Ferrer; S. Ferrucci; J. S. Fok; D. Fomina; L. Fonacier; G. Fouda; I. Francescantonio; A. Fukunaga; C. A. Galvan Calle; E. Garcia; K. Gáspár; A. Gelincik; S. Geng; K. Godse; M. Gonçalo; M. Gotua; C. Grattan; M. Grosber; G. Guidos Fogelbach; M. Guilarte; R. Guillod; E. Hamelmann; J. Hawkes; K. Hayama; R. Heuer; M. Hide; W. Hoetzenecker; N. Inomata; H. R. Kang; A. Kaplan; A. Kapp; M. Karam; A. Kasperska-Zajac; C. H. Katelaris; A. Kessel; M. Khoshkhui; B. Kim; T. Kinaciyan; E. Kocatürk; M. Kolacinska-Flont; P. Kolkhir; G. N. Konstantinou; M. Kosnik; D. Krasowska; K. Kulthanan; M. S. Kumaran; I. Kuprys-Lipinska; M. Labrador; J. I. Larco; D. Larenas-Linnemann; E. Latysheva; E. Lazaridou; P. H. Li; H. Lima; U. Lippert; M. Magerl; M. Makris; J. Alves Marcelino; A. V. Marzano; I. Medina; R. Meshkova; D. Micallef; R. Mohammed Ali; C. G. Mortz; M. Munoz; H. N.G. Oude Elberink; A. Nakonechna; I. Nasr; A. Nast; E. Netchiporouk; E. Nettis; S. Nieto; I. Ogueta Canales; T. L. Okas; R. L. Orfali; E. Özkaya; C. Parisi; A. Pennitz; R. Pawankar; M. P. Pereira; J. Peter; E. Petkova; P. D. Pigatto; I. Podder; T. Popov; G. Porebski; P. Pyatilova; G. D. Ramon; H. A. Ratti Sisa; M. Recto; K. Ress; K. Ridge; M. Riedl; C. Ritchie; N. Rosario Filho; I. Rosmaninho; M. Rudenko; M. Rukhadze; K. Rutkowski; V. Sabato; U. M. Sahiner; S. Saini; F. Saleh Al Sabbagh; A. Salman; F. Salvo; J. Sanchez; A. Santucci; S. Schliemann; P. Schmid-Grendelmeier; B. E. Sekerel; F. Serpa; F. Sheikh; J. Sheikh; H. Shendi; F. Siebenhaar; M. Sonomjamts; A. Soria; B. Sousa Pinto; M. Staevska; P. Staubach; M. Stephan; K. Stevanovic; L. Stingeni; M. Stobiecki; Küçük Su Küçük; G. Sussman; A. Szegedi; S. Takahagi; A. Tanaka; N. Teovska Mitrevska; S. F. Thomsen; E. Toubi; F. Tsatsou; M. Turk; Z. Vadasz; A. Valerieva; S. Valle; M. V. Doorn; B. Veleiro Perez; C. E. Vera Ayala; C. Vestergaard; R. J. Vieira; C. W. Maruta; B. Wedi; R. N. Werner; E. W.Y. Yap; P. Xepapadaki; Y. Xiang; Y. M. Ye; P. Yong; G. Yosipovitch; A. Z.J. Zalewska-Janowska; C. Zeyen; Z. Zhao; M. Metz; A. M. Giménez-Arnau

doi:10.1111/all.70210

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria

T. Zuberbier
, Z. Abdul Hameed Ansari
, A. H. Abdul Latiff
, M. M. Abuzakouk
, M. S. Agcaoili-De Jesus
, R. C. Agondi
, M. Al-Ahmad
, A. A. Alangari
, H. Alhameli
, C. D. Alonso Bello
, S. Alshareef
, S. Al-Tamemi
, S. Altrichter
, H. Al Wahshi
, S. Aquilina
, M. Araújo
, R. Arnaout
, R. Asero
, B. Ballmer-Weber
, C. Bangert

A. Bauer, M. Ben-Shoshan, J. Bernstein, C. Bindslev-Jensen, M. Bizjak, I. Boccon-Gibod, H. Bonnekoh, L. Bouillet, K. Brockow, Z. Brzoza, M. Bulatović Ćalasan, A. Bulkhi, T. Buttgereit, A. Bygum, T. Caballero, O. Calderon, R. Campos, M. Cancian, E. Carne, M. A. Castor, I. Cerecedo, T. Çetinarslan, I. Cherrez-Ojeda, N. Chkhikvadze, H. J. Chong-Neto, K. Choo, G. Christoff, C. Y. Chu, K. Ciupka, N. Conlon, C. Costa, T. Craig, P. Criado, I. Danilycheva, R. Darlenski, E. De Arruda Chaves, L. de Montjoye, M. S. Doutre, A. Du-Thanh, D. Ebo, S. Elkhalifa, S. Elmariah, T. El-Shanawany, L. F. Ensina, R. Ertaş, R. Fachini Jardim Criado, M. Ferrer, S. Ferrucci, J. S. Fok, D. Fomina, L. Fonacier, G. Fouda, I. Francescantonio, A. Fukunaga, C. A. Galvan Calle, E. Garcia, K. Gáspár, A. Gelincik, S. Geng, K. Godse, M. Gonçalo, M. Gotua, C. Grattan, M. Grosber, G. Guidos Fogelbach, M. Guilarte, R. Guillod, E. Hamelmann, J. Hawkes, K. Hayama, R. Heuer, M. Hide, W. Hoetzenecker, N. Inomata, H. R. Kang, A. Kaplan, A. Kapp, M. Karam, A. Kasperska-Zajac, C. H. Katelaris, A. Kessel, M. Khoshkhui, B. Kim, T. Kinaciyan, E. Kocatürk, M. Kolacinska-Flont, P. Kolkhir, G. N. Konstantinou, M. Kosnik, D. Krasowska, K. Kulthanan, M. S. Kumaran, I. Kuprys-Lipinska, M. Labrador, J. I. Larco, D. Larenas-Linnemann, E. Latysheva, E. Lazaridou, P. H. Li, H. Lima, U. Lippert, M. Magerl, M. Makris, J. Alves Marcelino, A. V. Marzano, I. Medina, R. Meshkova, D. Micallef, R. Mohammed Ali, C. G. Mortz, M. Munoz, H. N.G. Oude Elberink, A. Nakonechna, I. Nasr, A. Nast, E. Netchiporouk, E. Nettis, S. Nieto, I. Ogueta Canales, T. L. Okas, R. L. Orfali, E. Özkaya, C. Parisi, A. Pennitz, R. Pawankar, M. P. Pereira, J. Peter, E. Petkova, P. D. Pigatto, I. Podder, T. Popov, G. Porebski, P. Pyatilova, G. D. Ramon, H. A. Ratti Sisa, M. Recto, K. Ress, K. Ridge, M. Riedl, C. Ritchie, N. Rosario Filho, I. Rosmaninho, M. Rudenko, M. Rukhadze, K. Rutkowski, V. Sabato, U. M. Sahiner, S. Saini, F. Saleh Al Sabbagh, A. Salman, F. Salvo, J. Sanchez, A. Santucci, S. Schliemann, P. Schmid-Grendelmeier, B. E. Sekerel, F. Serpa, F. Sheikh, J. Sheikh, H. Shendi, F. Siebenhaar, M. Sonomjamts, A. Soria, B. Sousa Pinto, M. Staevska, P. Staubach, M. Stephan, K. Stevanovic, L. Stingeni, M. Stobiecki, Küçük Su Küçük, G. Sussman, A. Szegedi, S. Takahagi, A. Tanaka, N. Teovska Mitrevska, S. F. Thomsen, E. Toubi, F. Tsatsou, M. Turk, Z. Vadasz, A. Valerieva, S. Valle, M. V. Doorn, B. Veleiro Perez, C. E. Vera Ayala, C. Vestergaard, R. J. Vieira, C. W. Maruta, B. Wedi, R. N. Werner, E. W.Y. Yap, P. Xepapadaki, Y. Xiang, Y. M. Ye, P. Yong, G. Yosipovitch, A. Z.J. Zalewska-Janowska, C. Zeyen, Z. Zhao, M. Metz, A. M. Giménez-Arnau

Charité – Universitätsmedizin Berlin
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
Royal Hospital Oman
Pantai Hospital Kuala Lumpur
Cleveland Clinic Abu Dhabi
Philippine General Hospital
Universidade de São Paulo
Kuwait University
King Saud University
Hospital Juárez de México
King Faisal Specialist Hospital and Research Centre
Sultan Qaboos University
Omani Society of Allergy & Clinical Immunology
Johannes Kepler University Linz
Mater Dei Hospital
Serviço de Imunoalergologia do Hospital Dona Estefânia
Clinica San Carlo
University of Zurich
Medical University of Vienna
Technische Universität Dresden
McGill University
University of Cincinnati
Department of Dermatology and Allergy Center
University of Ljubljana
University of Maribor
National Reference Center for Angiœdema CREAK
Technical University of Munich
University of Opole
Utrecht University
Umm Al-Qura University
University of Southern Denmark
Hospital Universitario La Paz
San Isidro
Universidade Federal da Bahia
Department of Systems Medicine
Allergy Service for Wales
Manisa Celal Bayar University
Respiralab Research Center
Center of Allergy and Immunology
Universidade Federal do Paraná
Singapore General Hospital
Medical Center Excelsior Ltd.
National Taiwan University
St James’s Hospital and Trinity College
Unidade Local de Saúde Santa Maria
Pennsylvania State University
Vinmec International Hospital
Fundação Universitaria do ABC, Faculdade de Medicina do ABC
Allegology
Excelsior Med Center/Acibadem Cityclinic Tokuda Hospital (Inpatients)
Clínica Anglo Americana
Université catholique de Louvain
University Hospital of Bordeaux
CHU Montpellier
University of Antwerp
University of Manchester
University of California at San Francisco
University Hospital of Wales
Universidade Federal de São Paulo
University of Health Sciences
University of Navarra
IRCCS Fondazione Ca'Granda – Ospedale Maggiore Policlinico - Milano
Box Hill Hospital
City Clinical Hospital 52
Sechenov First Moscow State Medical University
New York University
Food and Drug Allergy Center
Allergy and Immunology
Osaka Medical and Pharmaceutical University
Fundación Santa Fe de Bogotá
University of Debrecen
Istanbul University
Xi'an Jiaotong University
Dr. D.Y. Patil Medical College and Hospital
University of Coimbra
David Tatishvili Medical Center; David Tvildiani Medical University-AIETI Medical School
Guy's and St Thomas' NHS Foundation Trust
Vrije Universiteit Brussel
Instituto Politécnico Nacional
Hospital Universitari Vall d'Hebron
Autonomous University of Barcelona
aha! Allergiezentrum Schweiz
Bielefeld University
Portland
Nihon University
Hiroshima University
Hiroshima City Hiroshima Citizens Hospital
Showa University
Seoul National University
Medical University of South Carolina
Hannover Medical School
American University of Beirut
Medical University of Silesia in Katowice
Western Sydney University
Technion-Israel Institute of Technology
Mashhad University of Medical Sciences
Icahn School of Medicine at Mount Sinai
Koc University
Medical University of Łódź
424 General Military Training Hospital, Greece
Venereology and Pediatric Dermatology Clinic Medical University of Lublin
Mahidol University
Postgraduate Institute of Medical Education and Research
Clínica San Felipe
Centro de Excelencia en Asma y Alergia Larenas Hospital Médica Sur
Aristotle University of Thessaloniki
The University of Hong Kong
McMaster University
University of Göttingen
National and Kapodistrian University of Athens
Setúbal Hospital Centre
University of Milan
Centro Medico Vitae
Raisa Meshkova Smolensk State Medical University
Hamad Medical Corporation
University of Groningen
Imperial College Healthcare NHS Trust
University of Bari
Instituto Nacional de Pediatria
Pontificia Universidad Católica de Chile
University of Tartu
Hospital Italiano de Buenos Aires
Nippon Medical School
University of Cape Town
Medical University Sofia
IRCCS Istituto Ortopedico Galeazzi - Milano
College of Medicine & Sagore Dutta Hospital
University Hospital Sv. Ivan Rilski
University Hospital in Krakow
Jagiellonian University Medical College
Instituto de Alergia e Inmunologia del Sur
Uniclinic
University of the Philippines – PGH
Center of Allergology and Immunology
University of California at San Diego
Centro Hospitalar de Vila Nova de Gaia
London Allergy and Immunology Centre
Center Allergy & Immunology/Geomedi Teaching University
Hacettepe University
Johns Hopkins University
Al Kindi Specialized Hospital W.L.L
Acibadem Mehmet Ali Aydinlar University School of Medicine
Universidad de Antioquia
Rimini Infermi Hospital
Friedrich Schiller University Jena
Internal Medicine
Lalik Chowk
Kaiser Permanente
Sheikh Khalifa City Hospital
Mongolian National University of Medical Sciences
Assistance publique – Hôpitaux de Paris
University of Porto
Johannes Gutenberg University Mainz
University of Perugia
Bezmialem Vakif University
University of Toronto
JA Hiroshima General Hospital
Remedika General Hospital
University of Copenhagen
Erciyes University
Universidade Federal do Rio de Janeiro
Erasmus University Rotterdam
Hospital Juan Canalejo
Aarhus University
Hospital Pakar Sultanah Fatimah
Tongji University
Ajou University
Clinical Immunology and Allergy Department
University of Miami
Tianjin University of Traditional Chinese Medicine
Pompeu Fabra University

Research output: Contribution to journal › Article › peer-review

Abstract

This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA²LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), with the participation of 210 delegates from 107 national and international societies, from 59 countries. The consensus conference was held on December 6th, 2024. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease, defined by a rapid appearance of wheals, angioedema, or both. The lifetime prevalence of acute urticaria is estimated to be approximately 20%. Chronic urticaria, categorized as either chronic spontaneous urticaria or chronic inducible urticaria, is disabling, impairs quality of life, and affects performance at work and school, however, novel therapies are available. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.

Original language	English
Journal	Allergy: European Journal of Allergy and Clinical Immunology
DOIs	https://doi.org/10.1111/all.70210
State	Accepted/In press - 2026

Keywords

angioedema
consensus
evidence-based
hives
itch
mast cell
urticaria
wheals

Access to Document

10.1111/all.70210

Cite this

Zuberbier, T., Abdul Hameed Ansari, Z., Abdul Latiff, A. H., Abuzakouk, M. M., Agcaoili-De Jesus, M. S., Agondi, R. C., Al-Ahmad, M., Alangari, A. A., Alhameli, H., Alonso Bello, C. D., Alshareef, S., Al-Tamemi, S., Altrichter, S., Al Wahshi, H., Aquilina, S., Araújo, M., Arnaout, R., Asero, R., Ballmer-Weber, B., ... Giménez-Arnau, A. M. (Accepted/In press). The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria. Allergy: European Journal of Allergy and Clinical Immunology. https://doi.org/10.1111/all.70210

@article{4e8338fcac3f4244b3288839a2219877,

title = "The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria",

abstract = "This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), with the participation of 210 delegates from 107 national and international societies, from 59 countries. The consensus conference was held on December 6th, 2024. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease, defined by a rapid appearance of wheals, angioedema, or both. The lifetime prevalence of acute urticaria is estimated to be approximately 20\%. Chronic urticaria, categorized as either chronic spontaneous urticaria or chronic inducible urticaria, is disabling, impairs quality of life, and affects performance at work and school, however, novel therapies are available. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.",

keywords = "angioedema, consensus, evidence-based, hives, itch, mast cell, urticaria, wheals",

author = "T. Zuberbier and \{Abdul Hameed Ansari\}, Z. and \{Abdul Latiff\}, \{A. H.\} and Abuzakouk, \{M. M.\} and \{Agcaoili-De Jesus\}, \{M. S.\} and Agondi, \{R. C.\} and M. Al-Ahmad and Alangari, \{A. A.\} and H. Alhameli and \{Alonso Bello\}, \{C. D.\} and S. Alshareef and S. Al-Tamemi and S. Altrichter and \{Al Wahshi\}, H. and S. Aquilina and M. Ara{\'u}jo and R. Arnaout and R. Asero and B. Ballmer-Weber and C. Bangert and A. Bauer and M. Ben-Shoshan and J. Bernstein and C. Bindslev-Jensen and M. Bizjak and I. Boccon-Gibod and H. Bonnekoh and L. Bouillet and K. Brockow and Z. Brzoza and \{Bulatovi{\'c} {\'C}alasan\}, M. and A. Bulkhi and T. Buttgereit and A. Bygum and T. Caballero and O. Calderon and R. Campos and M. Cancian and E. Carne and Castor, \{M. A.\} and I. Cerecedo and T. {\c C}etinarslan and I. Cherrez-Ojeda and N. Chkhikvadze and Chong-Neto, \{H. J.\} and K. Choo and G. Christoff and Chu, \{C. Y.\} and K. Ciupka and N. Conlon and C. Costa and T. Craig and P. Criado and I. Danilycheva and R. Darlenski and \{De Arruda Chaves\}, E. and \{de Montjoye\}, L. and Doutre, \{M. S.\} and A. Du-Thanh and D. Ebo and S. Elkhalifa and S. Elmariah and T. El-Shanawany and Ensina, \{L. F.\} and R. Erta{\c s} and \{Fachini Jardim Criado\}, R. and M. Ferrer and S. Ferrucci and Fok, \{J. S.\} and D. Fomina and L. Fonacier and G. Fouda and I. Francescantonio and A. Fukunaga and \{Galvan Calle\}, \{C. A.\} and E. Garcia and K. G{\'a}sp{\'a}r and A. Gelincik and S. Geng and K. Godse and M. Gon{\c c}alo and M. Gotua and C. Grattan and M. Grosber and \{Guidos Fogelbach\}, G. and M. Guilarte and R. Guillod and E. Hamelmann and J. Hawkes and K. Hayama and R. Heuer and M. Hide and W. Hoetzenecker and N. Inomata and Kang, \{H. R.\} and A. Kaplan and A. Kapp and M. Karam and A. Kasperska-Zajac and Katelaris, \{C. H.\} and A. Kessel and M. Khoshkhui and B. Kim and T. Kinaciyan and E. Kocat{\"u}rk and M. Kolacinska-Flont and P. Kolkhir and Konstantinou, \{G. N.\} and M. Kosnik and D. Krasowska and K. Kulthanan and Kumaran, \{M. S.\} and I. Kuprys-Lipinska and M. Labrador and Larco, \{J. I.\} and D. Larenas-Linnemann and E. Latysheva and E. Lazaridou and Li, \{P. H.\} and H. Lima and U. Lippert and M. Magerl and M. Makris and \{Alves Marcelino\}, J. and Marzano, \{A. V.\} and I. Medina and R. Meshkova and D. Micallef and \{Mohammed Ali\}, R. and Mortz, \{C. G.\} and M. Munoz and \{Oude Elberink\}, \{H. N.G.\} and A. Nakonechna and I. Nasr and A. Nast and E. Netchiporouk and E. Nettis and S. Nieto and \{Ogueta Canales\}, I. and Okas, \{T. L.\} and Orfali, \{R. L.\} and E. {\"O}zkaya and C. Parisi and A. Pennitz and R. Pawankar and Pereira, \{M. P.\} and J. Peter and E. Petkova and Pigatto, \{P. D.\} and I. Podder and T. Popov and G. Porebski and P. Pyatilova and Ramon, \{G. D.\} and \{Ratti Sisa\}, \{H. A.\} and M. Recto and K. Ress and K. Ridge and M. Riedl and C. Ritchie and \{Rosario Filho\}, N. and I. Rosmaninho and M. Rudenko and M. Rukhadze and K. Rutkowski and V. Sabato and Sahiner, \{U. M.\} and S. Saini and \{Saleh Al Sabbagh\}, F. and A. Salman and F. Salvo and J. Sanchez and A. Santucci and S. Schliemann and P. Schmid-Grendelmeier and Sekerel, \{B. E.\} and F. Serpa and F. Sheikh and J. Sheikh and H. Shendi and F. Siebenhaar and M. Sonomjamts and A. Soria and \{Sousa Pinto\}, B. and M. Staevska and P. Staubach and M. Stephan and K. Stevanovic and L. Stingeni and M. Stobiecki and \{Su K{\"u}{\c c}{\"u}k\}, K{\"u}{\c c}{\"u}k and G. Sussman and A. Szegedi and S. Takahagi and A. Tanaka and \{Teovska Mitrevska\}, N. and Thomsen, \{S. F.\} and E. Toubi and F. Tsatsou and M. Turk and Z. Vadasz and A. Valerieva and S. Valle and Doorn, \{M. V.\} and \{Veleiro Perez\}, B. and \{Vera Ayala\}, \{C. E.\} and C. Vestergaard and Vieira, \{R. J.\} and Maruta, \{C. W.\} and B. Wedi and Werner, \{R. N.\} and Yap, \{E. W.Y.\} and P. Xepapadaki and Y. Xiang and Ye, \{Y. M.\} and P. Yong and G. Yosipovitch and Zalewska-Janowska, \{A. Z.J.\} and C. Zeyen and Z. Zhao and M. Metz and Gim{\'e}nez-Arnau, \{A. M.\}",

note = "Publisher Copyright: {\textcopyright} 2026 Global Allergy and Asthma Excellence Network. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley \& Sons Ltd.",

year = "2026",

doi = "10.1111/all.70210",

language = "Ingl{\'e}s",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

issn = "0105-4538",

publisher = "Wiley-Blackwell Publishing Ltd",

}

Zuberbier, T, Abdul Hameed Ansari, Z, Abdul Latiff, AH, Abuzakouk, MM, Agcaoili-De Jesus, MS, Agondi, RC, Al-Ahmad, M, Alangari, AA, Alhameli, H, Alonso Bello, CD, Alshareef, S, Al-Tamemi, S, Altrichter, S, Al Wahshi, H, Aquilina, S, Araújo, M, Arnaout, R, Asero, R, Ballmer-Weber, B, Bangert, C, Bauer, A, Ben-Shoshan, M, Bernstein, J, Bindslev-Jensen, C, Bizjak, M, Boccon-Gibod, I, Bonnekoh, H, Bouillet, L, Brockow, K, Brzoza, Z, Bulatović Ćalasan, M, Bulkhi, A, Buttgereit, T, Bygum, A, Caballero, T, Calderon, O, Campos, R, Cancian, M, Carne, E, Castor, MA, Cerecedo, I, Çetinarslan, T, Cherrez-Ojeda, I, Chkhikvadze, N, Chong-Neto, HJ, Choo, K, Christoff, G, Chu, CY, Ciupka, K, Conlon, N, Costa, C, Craig, T, Criado, P, Danilycheva, I, Darlenski, R, De Arruda Chaves, E, de Montjoye, L, Doutre, MS, Du-Thanh, A, Ebo, D, Elkhalifa, S, Elmariah, S, El-Shanawany, T, Ensina, LF, Ertaş, R, Fachini Jardim Criado, R, Ferrer, M, Ferrucci, S, Fok, JS, Fomina, D, Fonacier, L, Fouda, G, Francescantonio, I, Fukunaga, A, Galvan Calle, CA, Garcia, E, Gáspár, K, Gelincik, A, Geng, S, Godse, K, Gonçalo, M, Gotua, M, Grattan, C, Grosber, M, Guidos Fogelbach, G, Guilarte, M, Guillod, R, Hamelmann, E, Hawkes, J, Hayama, K, Heuer, R, Hide, M, Hoetzenecker, W, Inomata, N, Kang, HR, Kaplan, A, Kapp, A, Karam, M, Kasperska-Zajac, A, Katelaris, CH, Kessel, A, Khoshkhui, M, Kim, B, Kinaciyan, T, Kocatürk, E, Kolacinska-Flont, M, Kolkhir, P, Konstantinou, GN, Kosnik, M, Krasowska, D, Kulthanan, K, Kumaran, MS, Kuprys-Lipinska, I, Labrador, M, Larco, JI, Larenas-Linnemann, D, Latysheva, E, Lazaridou, E, Li, PH, Lima, H, Lippert, U, Magerl, M, Makris, M, Alves Marcelino, J, Marzano, AV, Medina, I, Meshkova, R, Micallef, D, Mohammed Ali, R, Mortz, CG, Munoz, M, Oude Elberink, HNG, Nakonechna, A, Nasr, I, Nast, A, Netchiporouk, E, Nettis, E, Nieto, S, Ogueta Canales, I, Okas, TL, Orfali, RL, Özkaya, E, Parisi, C, Pennitz, A, Pawankar, R, Pereira, MP, Peter, J, Petkova, E, Pigatto, PD, Podder, I, Popov, T, Porebski, G, Pyatilova, P, Ramon, GD, Ratti Sisa, HA, Recto, M, Ress, K, Ridge, K, Riedl, M, Ritchie, C, Rosario Filho, N, Rosmaninho, I, Rudenko, M, Rukhadze, M, Rutkowski, K, Sabato, V, Sahiner, UM, Saini, S, Saleh Al Sabbagh, F, Salman, A, Salvo, F, Sanchez, J, Santucci, A, Schliemann, S, Schmid-Grendelmeier, P, Sekerel, BE, Serpa, F, Sheikh, F, Sheikh, J, Shendi, H, Siebenhaar, F, Sonomjamts, M, Soria, A, Sousa Pinto, B, Staevska, M, Staubach, P, Stephan, M, Stevanovic, K, Stingeni, L, Stobiecki, M, Su Küçük, K, Sussman, G, Szegedi, A, Takahagi, S, Tanaka, A, Teovska Mitrevska, N, Thomsen, SF, Toubi, E, Tsatsou, F, Turk, M, Vadasz, Z, Valerieva, A, Valle, S, Doorn, MV, Veleiro Perez, B, Vera Ayala, CE, Vestergaard, C, Vieira, RJ, Maruta, CW, Wedi, B, Werner, RN, Yap, EWY, Xepapadaki, P, Xiang, Y, Ye, YM, Yong, P, Yosipovitch, G, Zalewska-Janowska, AZJ, Zeyen, C, Zhao, Z, Metz, M & Giménez-Arnau, AM 2026, 'The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria', Allergy: European Journal of Allergy and Clinical Immunology. https://doi.org/10.1111/all.70210

TY - JOUR

T1 - The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria

AU - Zuberbier, T.

AU - Abdul Hameed Ansari, Z.

AU - Abdul Latiff, A. H.

AU - Abuzakouk, M. M.

AU - Agcaoili-De Jesus, M. S.

AU - Agondi, R. C.

AU - Al-Ahmad, M.

AU - Alangari, A. A.

AU - Alhameli, H.

AU - Alonso Bello, C. D.

AU - Alshareef, S.

AU - Al-Tamemi, S.

AU - Altrichter, S.

AU - Al Wahshi, H.

AU - Aquilina, S.

AU - Araújo, M.

AU - Arnaout, R.

AU - Asero, R.

AU - Ballmer-Weber, B.

AU - Bangert, C.

AU - Bauer, A.

AU - Ben-Shoshan, M.

AU - Bernstein, J.

AU - Bindslev-Jensen, C.

AU - Bizjak, M.

AU - Boccon-Gibod, I.

AU - Bonnekoh, H.

AU - Bouillet, L.

AU - Brockow, K.

AU - Brzoza, Z.

AU - Bulatović Ćalasan, M.

AU - Bulkhi, A.

AU - Buttgereit, T.

AU - Bygum, A.

AU - Caballero, T.

AU - Calderon, O.

AU - Campos, R.

AU - Cancian, M.

AU - Carne, E.

AU - Castor, M. A.

AU - Cerecedo, I.

AU - Çetinarslan, T.

AU - Cherrez-Ojeda, I.

AU - Chkhikvadze, N.

AU - Chong-Neto, H. J.

AU - Choo, K.

AU - Christoff, G.

AU - Chu, C. Y.

AU - Ciupka, K.

AU - Conlon, N.

AU - Costa, C.

AU - Craig, T.

AU - Criado, P.

AU - Danilycheva, I.

AU - Darlenski, R.

AU - De Arruda Chaves, E.

AU - de Montjoye, L.

AU - Doutre, M. S.

AU - Du-Thanh, A.

AU - Ebo, D.

AU - Elkhalifa, S.

AU - Elmariah, S.

AU - El-Shanawany, T.

AU - Ensina, L. F.

AU - Ertaş, R.

AU - Fachini Jardim Criado, R.

AU - Ferrer, M.

AU - Ferrucci, S.

AU - Fok, J. S.

AU - Fomina, D.

AU - Fonacier, L.

AU - Fouda, G.

AU - Francescantonio, I.

AU - Fukunaga, A.

AU - Galvan Calle, C. A.

AU - Garcia, E.

AU - Gáspár, K.

AU - Gelincik, A.

AU - Geng, S.

AU - Godse, K.

AU - Gonçalo, M.

AU - Gotua, M.

AU - Grattan, C.

AU - Grosber, M.

AU - Guidos Fogelbach, G.

AU - Guilarte, M.

AU - Guillod, R.

AU - Hamelmann, E.

AU - Hawkes, J.

AU - Hayama, K.

AU - Heuer, R.

AU - Hide, M.

AU - Hoetzenecker, W.

AU - Inomata, N.

AU - Kang, H. R.

AU - Kaplan, A.

AU - Kapp, A.

AU - Karam, M.

AU - Kasperska-Zajac, A.

AU - Katelaris, C. H.

AU - Kessel, A.

AU - Khoshkhui, M.

AU - Kim, B.

AU - Kinaciyan, T.

AU - Kocatürk, E.

AU - Kolacinska-Flont, M.

AU - Kolkhir, P.

AU - Konstantinou, G. N.

AU - Kosnik, M.

AU - Krasowska, D.

AU - Kulthanan, K.

AU - Kumaran, M. S.

AU - Kuprys-Lipinska, I.

AU - Labrador, M.

AU - Larco, J. I.

AU - Larenas-Linnemann, D.

AU - Latysheva, E.

AU - Lazaridou, E.

AU - Li, P. H.

AU - Lima, H.

AU - Lippert, U.

AU - Magerl, M.

AU - Makris, M.

AU - Alves Marcelino, J.

AU - Marzano, A. V.

AU - Medina, I.

AU - Meshkova, R.

AU - Micallef, D.

AU - Mohammed Ali, R.

AU - Mortz, C. G.

AU - Munoz, M.

AU - Oude Elberink, H. N.G.

AU - Nakonechna, A.

AU - Nasr, I.

AU - Nast, A.

AU - Netchiporouk, E.

AU - Nettis, E.

AU - Nieto, S.

AU - Ogueta Canales, I.

AU - Okas, T. L.

AU - Orfali, R. L.

AU - Özkaya, E.

AU - Parisi, C.

AU - Pennitz, A.

AU - Pawankar, R.

AU - Pereira, M. P.

AU - Peter, J.

AU - Petkova, E.

AU - Pigatto, P. D.

AU - Podder, I.

AU - Popov, T.

AU - Porebski, G.

AU - Pyatilova, P.

AU - Ramon, G. D.

AU - Ratti Sisa, H. A.

AU - Recto, M.

AU - Ress, K.

AU - Ridge, K.

AU - Riedl, M.

AU - Ritchie, C.

AU - Rosario Filho, N.

AU - Rosmaninho, I.

AU - Rudenko, M.

AU - Rukhadze, M.

AU - Rutkowski, K.

AU - Sabato, V.

AU - Sahiner, U. M.

AU - Saini, S.

AU - Saleh Al Sabbagh, F.

AU - Salman, A.

AU - Salvo, F.

AU - Sanchez, J.

AU - Santucci, A.

AU - Schliemann, S.

AU - Schmid-Grendelmeier, P.

AU - Sekerel, B. E.

AU - Serpa, F.

AU - Sheikh, F.

AU - Sheikh, J.

AU - Shendi, H.

AU - Siebenhaar, F.

AU - Sonomjamts, M.

AU - Soria, A.

AU - Sousa Pinto, B.

AU - Staevska, M.

AU - Staubach, P.

AU - Stephan, M.

AU - Stevanovic, K.

AU - Stingeni, L.

AU - Stobiecki, M.

AU - Su Küçük, Küçük

AU - Sussman, G.

AU - Szegedi, A.

AU - Takahagi, S.

AU - Tanaka, A.

AU - Teovska Mitrevska, N.

AU - Thomsen, S. F.

AU - Toubi, E.

AU - Tsatsou, F.

AU - Turk, M.

AU - Vadasz, Z.

AU - Valerieva, A.

AU - Valle, S.

AU - Doorn, M. V.

AU - Veleiro Perez, B.

AU - Vera Ayala, C. E.

AU - Vestergaard, C.

AU - Vieira, R. J.

AU - Maruta, C. W.

AU - Wedi, B.

AU - Werner, R. N.

AU - Yap, E. W.Y.

AU - Xepapadaki, P.

AU - Xiang, Y.

AU - Ye, Y. M.

AU - Yong, P.

AU - Yosipovitch, G.

AU - Zalewska-Janowska, A. Z.J.

AU - Zeyen, C.

AU - Zhao, Z.

AU - Metz, M.

AU - Giménez-Arnau, A. M.

PY - 2026

Y1 - 2026

N2 - This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), with the participation of 210 delegates from 107 national and international societies, from 59 countries. The consensus conference was held on December 6th, 2024. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease, defined by a rapid appearance of wheals, angioedema, or both. The lifetime prevalence of acute urticaria is estimated to be approximately 20%. Chronic urticaria, categorized as either chronic spontaneous urticaria or chronic inducible urticaria, is disabling, impairs quality of life, and affects performance at work and school, however, novel therapies are available. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.

AB - This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), with the participation of 210 delegates from 107 national and international societies, from 59 countries. The consensus conference was held on December 6th, 2024. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease, defined by a rapid appearance of wheals, angioedema, or both. The lifetime prevalence of acute urticaria is estimated to be approximately 20%. Chronic urticaria, categorized as either chronic spontaneous urticaria or chronic inducible urticaria, is disabling, impairs quality of life, and affects performance at work and school, however, novel therapies are available. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.

KW - angioedema

KW - consensus

KW - evidence-based

KW - hives

KW - itch

KW - mast cell

KW - urticaria

KW - wheals

UR - https://www.scopus.com/pages/publications/105029457442

U2 - 10.1111/all.70210

DO - 10.1111/all.70210

M3 - Artículo

AN - SCOPUS:105029457442

SN - 0105-4538

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

ER -

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria

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