Pulicaria vulgaris Gaertn. Essential oil: An alternative or complementary treatment for Leishmaniasis

Mehdi Sharifi-Rad; Bahar Salehi; Javad Sharifi-Rad; William N. Setzer; Marcello Iriti

doi:10.14715/cmb/2018.64.8.3

Pulicaria vulgaris Gaertn. Essential oil: An alternative or complementary treatment for Leishmaniasis

Mehdi Sharifi-Rad
, Bahar Salehi
, Javad Sharifi-Rad
, William N. Setzer
, Marcello Iriti

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Leishmaniasis is a neglected parasitic protozoal disease that affects approximately 12 million people and represents a public health problem in Iran. The objectives of this study were to obtain the essential oil (EO) from Pulicaria vulgaris Gaertn. growing in Iran and to carry out in-vitro antileishmanial screening of the EO against promastigotes of Leishmania major and Leishmania infantum. The EO from the aerial parts of P. vulgaris was extracted by hydrodistillation. Serial dilutions of the EO were screened for in-vitro antileishmanial activity using 96-well microtiter plates. The P. vulgaris EO was active against the promastigote forms of L. major and L. infantum, with IC₅₀ values of 244.70 and 233.65 μg/mL, respectively. Pulicaria vulgaris EO may serve as an alternative or complementary treatment for leishmaniasis.

Original language	English
Pages (from-to)	18-21
Number of pages	4
Journal	Cellular and Molecular Biology
Volume	64
Issue number	8
DOIs	https://doi.org/10.14715/cmb/2018.64.8.3
State	Published - 2018
Externally published	Yes

Keywords

Iranian plants
Parasites
Protozoal diseases
Thymol

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.14715/cmb/2018.64.8.3

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title = "Pulicaria vulgaris Gaertn. Essential oil: An alternative or complementary treatment for Leishmaniasis",

abstract = "Leishmaniasis is a neglected parasitic protozoal disease that affects approximately 12 million people and represents a public health problem in Iran. The objectives of this study were to obtain the essential oil (EO) from Pulicaria vulgaris Gaertn. growing in Iran and to carry out in-vitro antileishmanial screening of the EO against promastigotes of Leishmania major and Leishmania infantum. The EO from the aerial parts of P. vulgaris was extracted by hydrodistillation. Serial dilutions of the EO were screened for in-vitro antileishmanial activity using 96-well microtiter plates. The P. vulgaris EO was active against the promastigote forms of L. major and L. infantum, with IC50 values of 244.70 and 233.65 μg/mL, respectively. Pulicaria vulgaris EO may serve as an alternative or complementary treatment for leishmaniasis.",

keywords = "Iranian plants, Parasites, Protozoal diseases, Thymol",

author = "Mehdi Sharifi-Rad and Bahar Salehi and Javad Sharifi-Rad and Setzer, \{William N.\} and Marcello Iriti",

note = "Publisher Copyright: {\textcopyright} 2018 by the C.M.B. Association.",

year = "2018",

doi = "10.14715/cmb/2018.64.8.3",

language = "Ingl{\'e}s",

volume = "64",

pages = "18--21",

journal = "Cellular and Molecular Biology",

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TY - JOUR

T1 - Pulicaria vulgaris Gaertn. Essential oil

T2 - An alternative or complementary treatment for Leishmaniasis

AU - Sharifi-Rad, Mehdi

AU - Salehi, Bahar

AU - Sharifi-Rad, Javad

AU - Setzer, William N.

AU - Iriti, Marcello

PY - 2018

Y1 - 2018

N2 - Leishmaniasis is a neglected parasitic protozoal disease that affects approximately 12 million people and represents a public health problem in Iran. The objectives of this study were to obtain the essential oil (EO) from Pulicaria vulgaris Gaertn. growing in Iran and to carry out in-vitro antileishmanial screening of the EO against promastigotes of Leishmania major and Leishmania infantum. The EO from the aerial parts of P. vulgaris was extracted by hydrodistillation. Serial dilutions of the EO were screened for in-vitro antileishmanial activity using 96-well microtiter plates. The P. vulgaris EO was active against the promastigote forms of L. major and L. infantum, with IC50 values of 244.70 and 233.65 μg/mL, respectively. Pulicaria vulgaris EO may serve as an alternative or complementary treatment for leishmaniasis.

AB - Leishmaniasis is a neglected parasitic protozoal disease that affects approximately 12 million people and represents a public health problem in Iran. The objectives of this study were to obtain the essential oil (EO) from Pulicaria vulgaris Gaertn. growing in Iran and to carry out in-vitro antileishmanial screening of the EO against promastigotes of Leishmania major and Leishmania infantum. The EO from the aerial parts of P. vulgaris was extracted by hydrodistillation. Serial dilutions of the EO were screened for in-vitro antileishmanial activity using 96-well microtiter plates. The P. vulgaris EO was active against the promastigote forms of L. major and L. infantum, with IC50 values of 244.70 and 233.65 μg/mL, respectively. Pulicaria vulgaris EO may serve as an alternative or complementary treatment for leishmaniasis.

KW - Iranian plants

KW - Parasites

KW - Protozoal diseases

KW - Thymol

UR - https://www.scopus.com/pages/publications/85049971984

U2 - 10.14715/cmb/2018.64.8.3

DO - 10.14715/cmb/2018.64.8.3

M3 - Artículo

C2 - 29981679

AN - SCOPUS:85049971984

SN - 0145-5680

VL - 64

SP - 18

EP - 21

JO - Cellular and Molecular Biology

JF - Cellular and Molecular Biology

IS - 8

ER -

Pulicaria vulgaris Gaertn. Essential oil: An alternative or complementary treatment for Leishmaniasis

Abstract

Keywords

UN SDGs

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